Ask about this productRelated genes to: PNOC antibody
- Gene:
- PNOC NIH gene
- Name:
- prepronociceptin
- Previous symbol:
- -
- Synonyms:
- PPNOC, N/OFQ, NOP
- Chromosome:
- 8p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-05-28
- Date modifiied:
- 2016-10-05
Related products to: PNOC antibody
Related articles to: PNOC antibody
- Colorectal cancer (CRC) patients are immunocompromised, making them more susceptible to infection. The aim of this study was to estimate the prevalence of nosocomial infection among CRC patients at Prince Noora Oncology Centre in National Guard Health Affairs and to analyze the relationship between various pathogens and clinico-pathological characteristics of CRC. - Source: PubMed
Publication date: 2026/06/18
Aga Syed SameerKhan Muhammad AnwarRadhi Hamad MutlaqSaleh Abduljawad RamliAlghamdi Mohammed AbdulazizAlmutairi Muath BaderNissar Saniya - Bovine leukemia virus (BLV) is a cell-associated retrovirus of cattle transmitted mainly through the transfer of infected lymphocytes, but the possible role of hematophagous insects in its epidemiology remains incompletely understood. This study investigated BLV DNA in field-collected Culicoides biting midges and Stomoxys calcitrans from cattle farms in Poland. Insects were collected on four farms in northeastern Poland. Culicoides spp. were identified morphologically, classified by gonotrophic status, and pooled by species and status, whereas S. calcitrans were analyzed individually. DNA quality was verified by PCR targeting insect markers. Bovine host DNA was detected by PCR targeting mitochondrial cytochrome b in Culicoides and prepronociceptin (PNOC) in S. calcitrans. BLV proviral DNA was detected by TaqMan real-time PCR targeting the pol gene, followed by nested PCR and sequencing of a 400 bp fragment of the env gene. BLV DNA was detected in 20 of 138 Culicoides pools (14.5%). BLV copy numbers ranged from 2 to 19,000 copies per 500 ng of total DNA. All BLV-positive Culicoides pools were also positive for bovine cytochrome b DNA. Among the pol-positive pools, 18 were positive in nested env PCR, and 15 yielded high-quality sequences. One S. calcitrans specimen was also positive in both BLV assays. Sequences obtained from insects were identical to those from infected cattle, and phylogenetic analysis assigned them to genotypes G4 and G7, the predominant BLV genotypes circulating in Poland. These findings provide field-based molecular evidence that Culicoides biting midges and S. calcitrans can carry bovine blood and BLV DNA under natural farm conditions, supporting their possible role in the mechanical transfer of BLV between cattle. - Source: PubMed
Pluta AnetaKowalik JoannaRożek WojciechKwaśnik MałgorzataZiętek-Barszcz AnnaKuźmak Jacek - The arcuate nucleus (ARC) and ventromedial hypothalamus (VMH) are highly specialized hypothalamic nuclei controlling appetite and energy expenditure. Here, we demonstrate that human VMH and ARC neurons can be generated from pluripotent stem cells by fine-tuned timing and duration of bone morphogenetic protein (BMP) exposure. We identified SHH/NKX2.1/FGF10/RAX/TBX3 posterior tuberal progenitors as the source of ARC cell types, including agouti-related peptide (AGRP)-, prepronociceptin (PNOC)-, growth-hormone-releasing hormone (GHRH)-, and thyrotropin-releasing hormone (TRH)-expressing neurons and β2-tanycytes. Differentiated ARC cultures showed high transcriptomic similarity to human ARC and responded to energy homeostasis-regulatory peptides including leptin, glucagon-like peptide 1 (GLP-1), ghrelin, and fibroblast growth factor 1 (FGF1). In contrast, anterior tuberal TBX3 progenitors generated VMH-associated neurons expressing NR5A1, SOX14, and GPR149. Strikingly, two transcriptionally distinct pro-opiomelanocortin (POMC) subpopulations emerged from these lineages, mapping spatially to either the ARC (POMC/TBX3/NR5A2) or the VMH (POMC/SOX14/NR5A1). This model provides a cellular platform to study human hypothalamic subtype specification and pathways involved in central appetite regulation. - Source: PubMed
Publication date: 2026/06/08
Abay-Nørgaard ZehraMueller Anika KHänninen ErnoRausch DylanPiilgaard LouiseTrujillo Lucía SenaFedrizzi LorenzoChristensen Jens BagerSalvador AlisonSchörling Alrik LMottelson Noah WulffQin QiuyuSampath ShruthiHersbach BobHenkenjohann JonasPeeters SofieNikulina ViktoriiaKruse Charlotte HøyLi YuanChinnaiya KavithaPlaczek MarysiaKajtez JankoPers Tune HKirkeby Agnete - To investigate antimicrobial usage patterns, indications, and outcomes in end-of-life (EOL) oncology patients at Princess Noorah Oncology Center (PNOC), King Abdulaziz Medical City, Jeddah, Saudi Arabia. The use of antimicrobials in oncology patients in EOL care has raised concerns about their appropriateness and the increasing issue of antimicrobial resistance. - Source: PubMed
Publication date: 2026/02/07
Almouaalamy Nabil ABanjar Lama AHassani Hattan AAlqerafi Ahmed AEzzi Abdulrahman IAlaslab Bader KAllhybi Abdulaziz KAljohani Abdulaziz NAlmouaalamy Nora NAlmarhabi Hassan A - Diffuse midline glioma, H3K27-altered (DMG), is an aggressive and uniformly fatal paediatric brain tumour arising in midline structures and characterised by substantial microglial infiltration. We investigated whether microglia adopt a reactive state in response to DMG cells that functionally contributes to tumour progression. Transcriptomic profiling of microglia exposed to DMG, H3K27M cells, together with analysis of tumour associated myeloid cells isolated from DMG patient biopsies, revealed a pronounced upregulation of extracellular matrix (ECM) components, including fibronectin. Single cell transcriptomic analysis further identified microglia as the primary fibronectin expressing cell population within human DMG, H3K27M tumours. Functional invasion assays using a panel of patient-derived DMG, H3K27M cells, revealed that microglia-derived fibronectin significantly enhances tumour cell invasiveness, while its chemical inhibition with RGDS peptide or Avapritinib or its genetic silencing using small-interfering RNAs effectively suppresses invasion. Across independent patient cohorts (Kids First, PNOC, and CBTTC), and in archival tissues, DMG tumours were found to exhibit elevated expression of ECM components, and high fibronectin expression that correlated with poor prognosis. These findings suggest that microglia actively contribute to DMG invasiveness through ECM component production, identifying fibronectin as a potential therapeutic target in this lethal paediatric cancer. - Source: PubMed
Publication date: 2026/05/30
Keane LilyŠkandík MartinPosada-Pérez MercedesBose RajDesito Johnvan der Linde EsmeeEngskog-Vlachos PinelopiCeccatelli SandraGreen Adam LJoseph Bertrand