Ask about this productRelated genes to: FGF13 antibody
- Gene:
- FGF13 NIH gene
- Name:
- fibroblast growth factor 13
- Previous symbol:
- -
- Synonyms:
- FHF2, FGF2
- Chromosome:
- Xq26.3-q27.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-16
- Date modifiied:
- 2018-02-13
Related products to: FGF13 antibody
Related articles to: FGF13 antibody
- Osteoporotic fracture (OPF) disrupts bone homeostasis via resorption-formation imbalance. This study investigates the expression and role of the long non-coding RNA FGF13 antisense RNA 1 (FGF13-AS1) in OPF bone healing. - Source: PubMed
Publication date: 2026/04/22
Yao ShanchuanMeng JiandeQin ZhouZhang Yuanyuan - - Source: PubMed
Liao XianghuiLi TuhuaYang LiLi HaiwenLi WeiruLiu YutingXie Zhong - Pathogenic variants within the unique N-terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X-linked dominant epileptic encephalopathy (DEE). - Source: PubMed
Publication date: 2026/03/11
Mignot CyrilPapathanasiou Terzi Matthildi AthinaRavelli ClaudiaBosch ElisabethLin XueqinTrauffler AdelineCaumes RoselineFry Andrew EFort ClementineGauthe GaelleTrollmann ReginaWirth ThomasAnheim MathieuMéneret AurélieRoze Emmanuelde Sainte Agathe Jean-MadeleineHe HailanPanagiotakaki EleniLesca GaëtanReis AndréDoummar DianeSmol ThomasVasileiou Georgia - Alzheimer's disease (AD) represents a primary contributor to cognitive deterioration in the elderly population. Mitochondrial dysfunction, which is closely associated with microtubule instability, contributes to AD progression. TUBB2A, a key microtubule protein, is essential for mitochondrial transport and neuronal function. This study investigates how DNA methylation of FGF13 affects mitochondrial function and its role in AD via the FGF13/TUBB2A axis. AD mouse models were established by injecting Aβ into the hippocampus, and dual-fluorescence staining was employed to quantify the expression levels of FGF13 and TUBB2A in different neural cell types in brain tissue. Western blotting assessed microtubule stability and mitochondrial function in the hippocampus. Nissl and TUNEL staining were used to detect neuronal survival and apoptosis, and transmission electron microscopy was used to observe the ultrastructure of mitochondria. Flow cytometry was employed to determine mitochondrial membrane potential in hippocampal tissue, and Methylation-Specific PCR was used to detect the methylation levels of FGF13. Co-immunoprecipitation experiments verified the interaction between FGF13 and TUBB2A. Mitochondrial dysfunction exists in the hippocampal tissue of AD mice. Overexpression of FGF13 alleviated mitochondrial ROS, enhanced microtubule stability, increased mitochondrial membrane potential, and reduced neuronal apoptosis, thereby improving symptoms. FGF13 was found to be methylated, and its methylation affected its direct binding with TUBB2A. Overexpression of FGF13's protective effects on neurons could be reversed by knocking down TUBB2A. The expression of FGF13 is reduced in AD mouse neurons, which is associated with its high methylation state. Overexpression of FGF13 improves microtubule stability and mitochondrial function in hippocampal neurons through interaction with TUBB2A, suggesting a potential therapeutic relevance in AD. - Source: PubMed
Ren DanZhu HongZhang TingXiao LanXu JiangxiLi Ruomeng - Spinal cord injury (SCI) induces severe neurological impairment, exacerbated by secondary inflammation and disrupted neural circuitry. Inspired by the spinal cord's electromechanical microenvironment, we developed a biomimetic conductive nerve scaffold via directional freeze-casting of gelatin methacryloyl (GelMA) hydrogel incorporated with N-acetylcysteine-modified silver nanowires (NAC-AgNWs). The scaffold exhibits axially aligned microchannels, tunable mechanical strength, and conductivity akin to native spinal tissue. In a rat model of complete spinal cord transection (2 mm), the scaffold exhibited dual therapeutic effects: (1) early-stage anti-inflammatory modulation (mediated by the synergistic interplay between AgNWs and NAC), and (2) sustained neural reconstruction, evidenced by robust axonal bridging across the lesion, synapse reformation, and significant functional recovery. Integrated transcriptomic analyses revealed the FGF13/Ca/CaMK2A/CREB axis as the activated pathway driving neurite outgrowth and neural circuit reconstruction. This biomaterial design establishes a novel therapeutic paradigm for SCI repair, integrating structural guidance, immunomodulation, and activation of pro-regenerative signaling. - Source: PubMed
Publication date: 2026/02/16
Jiang MinghaoLu WenjieZhuang JunyuSong JiahuiZhao YanfangZhou ChengZhou YangboShu WeizhiZhu ZhongweiJiang LelinWu PingWu AiminSheng SunrenZhu SipinWang Zhouguang