Ask about this productRelated genes to: COPA antibody
- Gene:
- COPA NIH gene
- Name:
- coatomer protein complex subunit alpha
- Previous symbol:
- -
- Synonyms:
- HEP-COP
- Chromosome:
- 1q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-15
- Date modifiied:
- 2019-04-23
Related products to: COPA antibody
Related articles to: COPA antibody
- In small ruminants such as goats, gastrointestinal nematodes (GINs) are a major cause of disease, production loss and mortality. This study aimed to describe the dynamics of development and survival in both fecal matter and grass of the free-living stages of goat GINs during the rainy season in Salta Province, Argentina. Four experimental fecal contaminations were conducted on plots between October 2022 and April 2023, representing different seasonal conditions. Larval development time and rate, time of L3 larvae persistence in fecal matter and grass, and migration to pasture, as well as the relationships of these parameters with environmental variables were evaluated. Significant differences were observed in all parasitological parameters between experimental plots. Development time ranged from 8 to 50 days, with slower development under early spring conditions, and was negatively correlated with humidity and accumulated rainfall. The development rate varied between 3.9% and 12.3% and showed a positive association with maximum temperature. The time of L3 larvae persistence time in fecal matter differed markedly between periods, with the longest survival observed in April, as confirmed by Kaplan-Meier analysis. The migration of larvae to pasture occurred between 4 and 12 days after detection in feces and was strongly influenced by rainfall and fecal dry matter. The time of L3 larvae persistence in pasture ranged from 30 to 53 days, with higher survival during early periods. The genus Trichostrongylus exhibited greater ecological plasticity and persistence than Haemonchus and Teladorsagia. These findings highlight the strong influence of environmental conditions on GIN epidemiology and provide the first local evidence describing the refuge dynamics of GINs in goats in Argentina. This information may contribute to the design of more effective and sustainable parasite control strategies. - Source: PubMed
Publication date: 2026/04/25
Olmos L HDíaz J PRuiz Á FEnriquez C ACopa G NTolaba M GSuarez V H - Copper (Cu) transporting ATPases represent a highly conserved subclass of P-type ATPases with critical roles in Cu export and metalloenzyme synthesis. Despite their important biological roles and association with a wide range of human diseases, no high-affinity small-molecule inhibitors have been described. Here, we identify MKV3 as a small molecule inhibitor of Cu-transporting P-type ATPases that targets a conserved Cu entry site to the translocation pathway. In silico docking against the ATP7B structure revealed a highly conserved pocket suitable for pharmacological inhibition. MKV3 bound human ATP7A and ATP7B with nanomolar affinity, competed with N-terminal metal-binding domains for access to the Cu entry site, and selectively inhibited CopA ATPase activity and Cu transport. Mechanistically, MKV3 blocked chaperone-mediated Cu delivery to the intramembranous CPC site of CopA that is essential for its transport function. We further identified a single charged P-domain residue that governed MKV3 affinity and potency across species. Functionally, MKV3 phenocopied the genetic loss of Cu-ATPases in bacteria, fungi, plants, zebrafish, and mammals, impairing copper-dependent enzymes, transporter trafficking, and copper tolerance. These findings establish a conserved, druggable vulnerability in Cu-ATPases and introduce MKV3 as a broadly active chemical tool to modulate copper homeostasis across biological kingdoms. - Source: PubMed
Publication date: 2026/05/14
Shanbhag Vinit CAnakpeba-Dinguyella SamuelGudekar NikitaConrad KristynAzubuogu ChiemerieProbst CorinnaRalle MartinaMediavilla María GCricco Julia AGarza Natalie MGohil Vishal MPeck ScottKumar SiddharthaNatarajan AmarnathHoradigala-Gamage Madujika AMeloni GabrieleSingh KamalPetris Michael J - Inborn errors of immunity (IEIs) encompass a heterogeneous group of more than 550 genetic conditions with variable ages of onset. A significant proportion of IEI arises from genetic variants that may not yet be fully elucidated or recorded in existing genomic databases. Molecular diagnoses are achieved in approximately 15-35% of IEI cases, yet in only 9-20% of individuals with predominant antibody deficiencies, particularly in adult cohorts. We aimed to evaluate whole genome sequencing (WGS) diagnostic yield in adults suspected to have IEI. Clinical assessments of the patients were carried out at tertiary medical institutions in Timisoara and Bucharest, Romania. The study cohort included a consecutive series of 21 adult patients (aged 19-60 years) with IEI phenotype, who underwent genetic analysis, using WGS as the first diagnostic approach. A definitive molecular diagnosis was confirmed in only 9.5% (2/21) of the participants, in and genes. Variants of uncertain significance (VUS) were detected in three patients (13.6%) in , , genes. For about half of the cohort the onset of the disease was noted in childhood. WGS as a first-line diagnostic strategy in a cohort of adults with IEI yielded a low diagnostic rate. There were significant delays in genetic diagnosis, as half of the cohort experienced childhood-onset symptoms. Results suggest that adult IEI diagnosis remains challenging, necessitating functional studies and longitudinal re-evaluation of genomic data. - Source: PubMed
Publication date: 2026/04/10
Pantea Cristina-LoredanaBataneant MihaelaJurcut CiprianCochino AlexisIoan AndreeaMunteanu Catalin VasileZimbru Cristian GUrtila PatriciaChirita-Emandi Adela - Copper (Cu) is an essential micronutrient that serves as a cofactor for redox enzymes but becomes toxic when unregulated. In bacteria, while Cu efflux systems are well characterized, mechanisms of Cu import remain poorly understood. Here, we characterize the major facilitator superfamily transporter CuiT (STM1486) as a key Cu importer in . Comparative genomics revealed that is evolutionarily conserved across Enterobacteriaceae, and structural modeling predicts a 12-transmembrane-helix architecture with conserved His, Met, and Cys residues suitable for Cu coordination. Functional analyses demonstrated that deletion of reduces intracellular Cu accumulation, slows Cu uptake kinetics, and diminishes expression of Cu-responsive genes, including , , , and . Conversely, overexpression of CuiT increases intracellular Cu but sensitizes cells to Cu stress, highlighting the need for tight regulation. Kinetic modeling indicates that CuiT mediates rapid Cu import, supporting larger intracellular Cu pools compared to influx transporters. These findings position CuiT as a central component of the Cu homeostasis network, linking Cu import to transcriptional regulation, redox balance, and stress adaptation. Our work provides mechanistic insights into bacterial Cu acquisition and suggests CuiT and associated pathways as potential targets for antimicrobial strategies. - Source: PubMed
Publication date: 2026/04/17
Zhao ZhenzhenDíaz Rodríguez Karla FMendez Andrea A ESommer Lisandro MMendes PedroSoncini Fernando CCheca Susana KPadilla-Benavides TeresitaArgüello José M - Pathological scars, including hypertrophic scars and keloids, are fibrotic skin disorders marked by excessive collagen deposition and persistent inflammation, yet effective treatments remain limited. - Source: PubMed
Publication date: 2026/04/08
Li PengfeiLuo ZuchengAli MohyeddinLi JianruiQi Fazhi