Ask about this productRelated genes to: GJC1 antibody
- Gene:
- GJC1 NIH gene
- Name:
- gap junction protein gamma 1
- Previous symbol:
- GJA7
- Synonyms:
- CX45
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-30
- Date modifiied:
- 2015-11-09
- Gene:
- GJD3 NIH gene
- Name:
- gap junction protein delta 3
- Previous symbol:
- GJC1
- Synonyms:
- CX31.9, GJA11, Cx30.2
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-29
- Date modifiied:
- 2017-08-14
Related products to: GJC1 antibody
Related articles to: GJC1 antibody
- experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated to further clarify the molecular basis of the low heart rate. - Source: PubMed
Publication date: 2018/09/02
Howarth F CQureshi M AJayaprakash PParekh KOz MDobrzynski HAdrian T E - Gap junctions are specialized plasma membrane domains consisting of channels formed by members of the connexin protein family. Gap junctional intercellular communication is often lost in cancers due to aberrant localization or downregulation of connexins, and connexins are therefore suggested to act as tumor suppressor genes in various tissues. The aim of this study was to investigate the expression pattern and DNA promoter methylation status of connexins in colorectal cancer. Expression of six (GJA1, GJA9, GJB1, GJB2, GJC1 and GJD3) connexin genes was detected in normal colonic tissue samples. GJC1 expression was reduced in colorectal carcinomas compared to normal tissue samples. All analyzed connexins were hypermethylated in colon cancer cell lines, although at various frequencies. GJA4, GJB6 and GJD2 were hypermethylated in 60% (29/48), 25% (12/48) and 96% (46/48) of primary colorectal carcinomas, respectively. However, the methylation status was not associated with gene expression. GJC1 has two alternative promoters, which were methylated in 42% (32/76) and 38% (25/65) of colorectal tumors, and in none of the normal mucosa samples. Expression of GJC1 was significantly lower in methylated compared with unmethylated samples (p < 0.01) and was restored in cell lines treated with the demethylating drug 5-aza-2'deoxycytidine. Taken together, DNA hypermethylation of the promoter region of GJC1, encoding connexin45, is an important mechanism in silencing gene expression in colorectal cancer. - Source: PubMed
Publication date: 2011/05/01
Sirnes SolveigHonne HildeAhmed DeeqaDanielsen Stine AskeRognum Torleiv OMeling Gunn IrenLeithe EdwardRivedal EdgarLothe Ragnhild ALind Guro E