Ask about this productRelated genes to: PCDHGB1 antibody
- Gene:
- PCDHGB1 NIH gene
- Name:
- protocadherin gamma subfamily B, 1
- Previous symbol:
- -
- Synonyms:
- PCDH-GAMMA-B1
- Chromosome:
- 5q31
- Locus Type:
- protocadherin
- Date approved:
- 2000-06-28
- Date modifiied:
- 2019-02-07
Related products to: PCDHGB1 antibody
Related articles to: PCDHGB1 antibody
- Prenatal exposure to organophosphate esters (OPEs) affects multiple child health domains. Alterations to the DNA methylome are a plausible mechanism through which these changes occur. This study characterized DNA methylation signatures at birth associated with prenatal OPE biomarkers. - Source: PubMed
Publication date: 2025/11/07
Schrott RoseAmes Jennifer LBarrett Emily SBennet Deborah HCroen Lisa AGeiger Sarah DKannan KurunthachalamRivera-Nunez ZorimarOh JiwonPeterson Alicia KPilsner J RichardSchmidt Rebecca JStarling Anne PZhu YeyiLadd-Acosta Christine - Chronic systemic inflammation is implicated in Alzheimer's disease (AD) pathogenesis and has measurable effects on blood cells. There is increasing interest in non-invasive diagnostic tools that use blood-based biomarkers for AD, such as DNA methylation. Notably, DNA methylation changes in blood are also linked to systemic inflammation. The evaluation of DNA methylation profiles in peripheral blood leukocytes as potential biomarkers for AD is promising. - Source: PubMed
Publication date: 2025/05/07
Chacón TatianaHernández Hernán G - Bromodomain and plant homeodomain (PHD) finger containing protein 1 (Brpf1) is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase (KAT) 6A/6B/7. Brpf1, KAT6A, and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual disability. Our previous work revealed strong and specific expression of Brpf1 in both the postnatal and adult forebrain, especially the hippocampus, which has essential roles in learning and memory. Here, we hypothesized that Brpf1 plays critical roles in the function of forebrain excitatory neurons, and that its deficiency leads to learning and memory deficits. To test this, we knocked out Brpf1 in forebrain excitatory neurons using CaMKIIa-Cre. We found that Brpf1 deficiency reduced the frequency of miniature excitatory postsynaptic currents and downregulated the expression of genes Pcdhgb1, Slc16a7, Robo3, and Rho, which are related to neural development, synapse function, and memory, thereby damaging spatial and fear memory in mice. These findings help explain the mechanisms of intellectual impairment in patients with BRPF1 mutation. - Source: PubMed
Zhao BaichengZhang HangLiu YingZu GaoyuZhang YuxiaoHu JiayiLiu ShuaiYou Linya - - Source: PubMed
Publication date: 2022/03/01
Li Li-XiHuang Jie-HongPan Li-ZhenZhang Xiao-LongPan You-GuiJin Ling-Jing - The pathophysiology and temporal dynamics of affected tissues in chronic rhinosinusitis (CRS) remain poorly understood. Here, we present a multiomics-based time-series assessment of nasal polyp biopsies from three patients with CRS, assessing natural variability over time and local response to systemic corticosteroid therapy. - Source: PubMed
Publication date: 2020/11/21
Hoggard MichaelJacob BincyWheeler DavidZoing MelissaChang KevinBiswas KristiMiddleditch MartinDouglas Richard GTaylor Michael W