Ask about this productRelated genes to: GJA3 antibody
- Gene:
- GJA3 NIH gene
- Name:
- gap junction protein alpha 3
- Previous symbol:
- CZP3
- Synonyms:
- CX46
- Chromosome:
- 13q12.11
- Locus Type:
- gene with protein product
- Date approved:
- 1990-02-12
- Date modifiied:
- 2015-11-09
Related products to: GJA3 antibody
Related articles to: GJA3 antibody
- Posterior polar cataract (PPC), a rare congenital cataract, is characterized by subcapsular opacities in the lens affecting vision and posing surgical challenges. Genetic heterogeneity exists, though several genes are implicated in its pathogenesis. This study reports on the genetic profile of late-onset PPC cases and identifies variations specific to posterior capsular rupture (PCR) during surgery. - Source: PubMed
Publication date: 2026/02/11
Sharma AnshulSharma NamrataAgarwal TusharSharma ArundhatiVajpayee Rasik B - Congenital cataract (CC), defined as lens opacity present at birth or in early infancy, is a major cause of reversible childhood blindness and shows marked genetic heterogeneity. This study aimed to investigate the genetic basis of CC in a multigenerational Chinese family. - Source: PubMed
Publication date: 2026/01/13
Zhou ChenchenLi KunkeZhou ZhenxingJian ShuhuiJin LingWang ChenghuZhang Xiaoqian - Drought and water scarcity, exacerbated by global warming, are enormous threats to global food sustainability and security. Poultry, in particular, are highly impacted by adverse environmental stressors. As nutrient absorption and intestinal integrity are critical for growth and performance, understanding the impact on the broiler gastrointestinal tract is highly relevant. Here, we examined the effect of chronic cyclic heat stress (HS) on the jejunal expression profile of tight-junction, gap-junction, adherens, and desmosome genes in the 4th generation of broiler lines divergently selected for low (LWE)- and high-water efficiency (HWE). Male HWE and LWE broilers (n = 240/line) were allotted to 12 environmental chambers (2 floor pens/chamber, 6 chambers/line, 20 birds/pen) and were exposed to cyclic HS (36°C for 9h/day from 9:00 am to 6:00 pm) or thermoneutral conditions (25°C) from day 29 to 49 of age in a 2 × 2 factorial design. Growth performance and mortality were recorded. At day 49, jejunal tissues were collected for molecular analyses using real-time quantitative PCR and immunoblot. Jejunal gene expression of multiple gut integrity factors were higher (P < 0.05) in the HWE as compared to the LWE lines, including claudin 22 (CLDN22), -34, occluding (OCDN), zona-occludin-2 (ZO-2), gap junction alpha1 (GJA1), GJA3, GJC1, and cadherin 1 (CDH1). CLDN8, -20, -25, -4, GJC2, and GJD2 were also greater (P < 0.05) in HWE, but were additionally downregulated (P < 0.05) during HS. Conversely PALS1-associated tight junction protein (PATJ) and desmocollin 1 (DSC1) mRNAs were significantly downregulated in the HWE as compared to the LWE broilers. Significant interactions between the line and environment were seen in CLDN1, where the expression was decreased in the LWE but increased in the HWE in HS. Additionally, CLDN15 and -16 genes were greatest in the HWE under TN conditions, while catenin alpha 2 (CTNNA2) was highest in the HWE during HS. Overall, the jejunal expression profile of key genes associated with intestinal barrier integrity likely contributes to the water efficiency phenotype and the response of these birds to HS. - Source: PubMed
Publication date: 2025/12/16
Greene Elizabeth SOrlowski SaraDridi Sami - Gap junction GJB2 (connexin 26, Cx26) gene mutations are responsible for >50 % of nonsyndromic hearing loss. The pathological changes mainly locate in the cochlea. However, little is known about genetic changes in the cochlea after Cx26 deficiency. In this study, we employed bulk Poly(A) RNA-Seq technique and found that Cx26 deficiency could cause many genes up- and down-regulated in the cochlea. One of the unexpected findings is significant upregulation of a gap junctional gene GJA3 (Cx46), which normally expresses in the eye rather than the ear. Quantitative PCR and digital droplet PCR further confirmed the promotion of Cx46 expression in the cochlea after Cx26 deficiency. Immunofluorescent staining showed that the promoted Cx46 was expressed at the same location as Cx26 expression in the cochlea and integrated into the same gap junctional plaques. This promotion is Cx26-specific; there was no promotion of Cx46 expression in the cochlea after knockout (KO) of Cx30 (GJB6), which is another predominant connexin co-expressed in the cochlea. Gene Set Enrichment Analysis (GSEA) revealed that Cx26 deficiency but not Cx30 KO upregulated a phototransduction pathway to promote the eye-specific gene Cx46 expression in the cochlea. This may present a natural compensation to the loss of Cx26 function, since both Cx26 and Cx46 have similar channel properties. Our findings also provide a new cue for developing a genetic approach to treat this common hereditary deafness. - Source: PubMed
Publication date: 2025/10/16
Zhai Tian-YingChen JinKong YongLiang ChunZhao Hong-Bo - Gill function in gas exchange and ion regulation is crucial for ionoregulatory homeostasis in teleost fishes, yet further research is needed to elucidate how cold stress affects these processes, particularly in relation to salinity-dependent tolerability. Indian medaka (Oryzias melastigma) were acclimated to freshwater (FW) and seawater (SW) environments before being exposed to cold stress at 18 °C for 168 h. The protein abundance of the apoptotic marker Caspase-3 increased significantly in SW-acclimated fish compared to controls, indicating a heightened apoptotic response under cold stress in SW conditions. Concurrently, the expression of the anti-apoptotic gene birc5 exhibited distinct patterns in FW and SW, suggesting differential regulatory mechanisms in response to cold exposure. Transcriptomic analysis revealed that cold stress significantly influenced genes related to ion regulation, osmoregulation, and cellular metabolism, with distinct pathways activated in FW and SW environments. Notably, SW-specific genes were predominantly involved in metabolic pathways and stress signaling, while FW-specific genes were linked to transport processes and cellular maintenance. Additionally, cold stress significantly affected the expression of Na/K-ATPase (NKA) subunits and ion transport genes, underscoring the impact of temperature and salinity on gill function. The study highlights the importance of tight junctions (TJ) and gap junction (GJ) in maintaining gill integrity during environmental stress, with differential regulation of key genes like ocln, cask, and gja3 in response to salinity and temperature shifts. These findings highlight the superior molecular and cellular adaptations of euryhaline fish in SW to cold stress, emphasizing how salinity enhances gill responses and suggesting potential strategies for improving cold tolerance in aquaculture. - Source: PubMed
Publication date: 2025/09/17
Ranasinghe NaveenAkram SalmanLee Shi-ShienLiao Pin-JhuYang Tsung-JuiKung Yu-ChiehLee Tsung-HanLiu Chia-Jui