Ask about this productRelated genes to: POSTN antibody
- Gene:
- POSTN NIH gene
- Name:
- periostin
- Previous symbol:
- -
- Synonyms:
- OSF-2, PN, periostin
- Chromosome:
- 13q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-10
- Date modifiied:
- 2016-04-05
Related products to: POSTN antibody
Related articles to: POSTN antibody
- Cancer-associated fibroblasts (CAFs) are central architects of immunosuppression and therapy resistance across malignancies, yet how tumor-intrinsic genomic instability instructs stromal reprogramming remains unresolved. Integrated single-cell transcriptomics and epigenomics of samples from patients with high-grade serous ovarian carcinoma revealed POSTN myofibroblast-like cancer-associated fibroblasts (myCAFs) and effector regulatory T cells (eT cells) as critical mediators of immunosuppression in tumors with high genomic instability. Mechanistically, unstable genomes activated tumor-intrinsic STING signaling, triggering WNT3a/7a secretion. WNT/β-catenin signaling in fibroblasts established a POSTN-dependent positive feedback loop that epigenetically locked cells into a POSTN myCAF lineage. These myCAFs reciprocally expanded eT cells and exhausted CD8 T cells, thereby converting genomic instability-driven immune activation into suppression and limiting poly(ADP-ribose) polymerase inhibitor (PARPi) efficacy. Therapeutic POSTN blockade reinvigorated T cell cytotoxicity, depleted eT cells, and potentiated PARP inhibition in ovarian and breast cancer models, overcoming resistance. Our work resolves the dual roles of genomic instability and identifies POSTN as a stromal-specific checkpoint to mediate immunosuppression in genomically unstable tumors. - Source: PubMed
Publication date: 2026/05/27
Liu DanTao KangjiaCai ChujunLin YayingYu RuidiXiong KairongYang WenLi XiongLuo YikaiSong ChunyanChi JianhuaPeng ZikunPan WenZhong QingLi HuayiXu ChengLiu XingzheZhao Guang-NianXia YuMa DingFang YongGao Qinglei - : Liver diseases cause more than 2 million annual deaths globally, accounting for 4% of the total global mortality rate. Hepatic fibrosis (HF) acts as an indispensable pathological mediator in the progressive deterioration of chronic liver diseases. Thus, the identification of effective anti-fibrotic targets and rational development of corresponding therapeutic agents are expected to deliver profound clinical value for patients suffering from chronic liver disorders. : An in vivo HF model was established to detect Kupffer cell (KC) polarization and periostin (POSTN) protein expression. In vitro, the CCK-8 (Cell Counting Kit-8) assay was applied to evaluate the regulatory effects of -knockdown macrophages on LX-2 cell activity. Conditional knockout mice with were constructed in vivo, and liver tissue samples were used for single-cell sequencing. Functional enrichment and cell differentiation prediction analyses were performed. CellChat was further utilized to characterize alterations in intercellular communication between -deficient KCs and adjacent liver cells. Finally, POSTN-targeted inhibitors were screened and validated via virtual drug screening and experiments. : In the HF model, the M2 polarization of KCs was associated with the upregulated expression of POSTN. In contrast, in vitro knockdown correlated with significantly suppressed LX-2 cell activation. Single-cell profiling suggests that deficiency in Kupffer cells is linked to remodeling of the hepatic microenvironment. In drug repurposing, Rhodiosin exhibited binding affinity to POSTN and was observed to inhibit macrophage M2 polarization. : POSTN may contribute to KC M2 polarization and be associated with remodeling of the intercellular interaction network among liver cells. Rhodiosin, as a POSTN-binding compound, shows potential for anti-hepatic fibrotic effects. - Source: PubMed
Publication date: 2026/05/11
Wang Meng-DanYuan Shuo-YingMijit ArzuZhang WenWu YangCheng Lu-Feng - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease characterized by heterogeneous phenotypes and endotypes, necessitating personalized therapeutic strategies. Precision medicine approaches integrating molecular biomarkers may improve treatment selection and disease stratification. In this prospective controlled study, we investigated the tissue-level immunohistochemical effects of oral corticosteroids (OCSs) and topical steroids on the expression of periostin, eotaxin, interleukin-4 (IL-4), transforming growth factor-β (TGF-β), and tumor necrosis factor-α (TNF-α) in nasal polyp tissue. Sixty-five patients eligible for endoscopic sinus surgery (ESS) were enrolled and divided into two groups: Group 1 (n = 42) received topical steroids combined with oral prednisone (40 mg/day for 7 days preoperatively), whereas Group 2 (n = 23) received topical steroids alone. Immunohistochemical analysis demonstrated a significant reduction in periostin and eotaxin expression in both epithelial and stromal compartments following OCS therapy, accompanied by increased TGF-β expression. No significant differences were observed in IL-4 or TNF-α expression. These findings indicate that short-term OCSs selectively modulate molecular pathways associated with eosinophilic inflammation and tissue remodeling in CRSwNP, supporting biomarker-driven precision medicine strategies. - Source: PubMed
Publication date: 2026/05/19
Radajewski KamilBurduk PawełWierzchowska MałgorzataAntosik PaulinaJóźwicki JakubBurduk JakubGrzanka Dariusz - Hepatocellular carcinoma (HCC) develops within a complex microenvironment in which cancer-associated fibroblasts (CAFs) are abundant, yet their heterogeneity and functional roles remain incompletely understood. Here, we integrated multi-site single-cell RNA sequencing of Normal liver, primary Tumor, portal vein tumor thrombus (PVTT), and metastatic Lymph node samples with bulk transcriptomic analysis, cell-cell communication inference, and functional assays to define stromal programs associated with HCC progression. We identified four transcriptionally distinct CAF subsets: SGCA mCAFs, POSTN mCAFs, TDO2 CAFs, and CXCL14 iCAFs, each showing site-specific distribution and distinct prognostic relevance. Among them, POSTN mCAFs were enriched for extracellular matrix organization and integrin signaling, and their signatures were consistently associated with poor overall survival across independent cohorts. Ligand-receptor analysis identified POSTN mCAFs as highly connected stromal hubs communicating with malignant and myeloid cells through ECM-integrin, collagen-SDC4, and chemokine pathways. Consistently, tumor-derived POSTN-high fibroblasts promoted hepatoma cell proliferation, migration, and invasion in vitro. Together, these findings identify POSTN mCAFs as a transcriptionally distinct and functionally pro-tumorigenic stromal subset in HCC, supporting POSTN-centered stromal programs as candidate markers of aggressive tumor microenvironments and a basis for future mechanistic investigation. - Source: PubMed
Publication date: 2026/05/22
Chen YalinLiu TingtingZhang ShichaoWu Dong - Developmental dysplasia of the hip (DDH) is a common pediatric orthopedic disorder that predisposes affected children to early-onset osteoarthritis (OA), yet the cellular heterogeneity and fibrotic remodeling of acetabular cartilage are poorly understood. - Source: PubMed
Publication date: 2026/04/28
Nijiati YaxierSong JunHuang PengLin ZichenPei YingzhiNing Bo