Ask about this productRelated genes to: IGFALS antibody
- Gene:
- IGFALS NIH gene
- Name:
- insulin like growth factor binding protein acid labile subunit
- Previous symbol:
- -
- Synonyms:
- ALS
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-28
- Date modifiied:
- 2015-11-23
Related products to: IGFALS antibody
Related articles to: IGFALS antibody
- The search for new biomarkers that allow an early diagnosis in sepsis has become a necessity in medicine. This study aims to identify protein biomarkers that differentiate sepsis from non-infectious systemic inflammatory response syndrome (NISIRS), addressing the need for early sepsis diagnosis. - Source: PubMed
Publication date: 2026/04/24
Ruiz-Sanmartín AdolfoRibas VicentSuñol DavidChiscano-Camón LuisMartín LauraBajaña IvánBastida JulianaLarrosa NievesGonzález Juan JoséCarrasco María DoloresCanela NúriaFerrer RicardRuiz-Rodríguez Juan Carlos - Circulating proteomics acts as an intermediate phenotype linking genetic susceptibility to MASLD. However, current evidence rarely establishes a direct concordance between serum protein levels and hepatic gene expression. We aimed to perform a multi-cohort joint analysis of serum proteomics and transcriptomics to characterize essential molecular features for MASLD. - Source: PubMed
Publication date: 2026/04/17
Xu JinjianGou WanglongWang XinyueRu DongmeiHu WeiChen JietengLi Bang-YanXi YueZheng Ju-ShengChen Yu-Ming - To explore the clinical phenotypes and genetic characteristics of a child with Acid-labile subunit deficiency (ALS). - Source: PubMed
Wang YanliLu ZhijinCheng ShuangxiWang YanYuan HaimingYuan Huihua - Ram fertility is essential for sheep production, influenced by genetic, physiological, behavioral, and environmental factors. This narrative review synthesizes findings from over 190 peer-reviewed publications to evaluate the phenotypic indicators, genetic architecture, molecular candidates, and management conditions influencing testicular development, semen quality, and reproductive performance in rams. - Source: PubMed
Publication date: 2026/02/09
Zheng KaiyueSinhalage KrishaniPolizel Guilherme Henrique GebimCánovas Ángela - Poor ovarian response (POR) constitutes a notable clinical challenge within the domain of assisted reproductive technology, primarily attributable to the lack of reliable biomarkers for precise diagnosis and treatment. This study reveals significantly reduced levels of insulin-like growth factor 1 (IGF-1) in the serum, follicular fluid (FF), and granulosa cells (GCs) of patients with POR in comparison to those exhibiting a normal ovarian response (NOR). Notably, FF IGF-1 concentrations demonstrated significant positive correlations with crucial IVF outcomes, including the numbers of metaphase II (MII) oocytes, 2-pronuclear zygotes, and high-quality embryos. To establish causality, we employed complementary in vivo models: systemic insulin-like growth factor binding protein acid labile subunit (Igfals) knockout mice and granulosa cell specific IGF-1 receptor (Igf-1r) knockout mice. These models collectively demonstrated that disruption of the IGF-1 signaling axis impairs follicle-stimulating hormone (FSH) responsiveness and arrests follicular development at the secondary stage, thereby recapitulating the core POR phenotype. Building on these mechanistic insights, we developed novel clinical prediction tools based on FF IGF-1: a POR risk model [Area under the curve (AUC) = 0.914] and a pregnancy outcome nomogram (AUC = 0.893), both of which significantly outperform traditional ovarian reserve parameters (such as anti-Müllerian hormone and antral follicle count). Decision curve analysis (DCA) further validated a substantial clinical net benefit. This study aids clinicians in the early identification of patients with POR and provides a theoretical foundation for timely intervention and adjustment of treatment strategies. - Source: PubMed
Publication date: 2026/01/29
Hu ZhuYu YuanyuanHuang GuanyouLi JinnanYang ChaoLong AizhuanTang JiaChen TengxiangZhao ShuyunZhang Tuo