Ask about this productRelated genes to: TSHR antibody
- Gene:
- TSHR NIH gene
- Name:
- thyroid stimulating hormone receptor
- Previous symbol:
- -
- Synonyms:
- LGR3
- Chromosome:
- 14q24-q31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-05
- Date modifiied:
- 2019-04-23
Related products to: TSHR antibody
Related articles to: TSHR antibody
- Hypothyroidism is a prevalent endocrine disorder characterized by the inadequate production of thyroid hormones (T3 and T4), leading to various physiological dysfunctions. Current treatments often involve synthetic hormone replacement, which is limited by some adverse effects. This study investigated the therapeutic efficacy of a methanolic extract of root (MEWS) in propylthiouracil (PTU)-induced hypothyroid rats. Forty rats were divided into five groups ( = 8): (1) negative control (NC), receiving no treatment; (2) positive control (PC), administered 0.05% w/v PTU to induce hypothyroidism; (3) control (WSC), treated with 500 mg/kg/day MEWS alone; (4) treatment (WST-500), receiving 500 mg/kg/day MEWS alongside PTU; and (5) combination therapy (CT-500), treated with both 500 mg/kg/day MEWS and 0.05% w/v PTU. Serum hormones (TSH, T3, T4) were measured by ELISA, thyroid histopathology was analyzed, and thyroperoxidase (TPO) and thyroglobulin (TG) gene expression were quantified by qPCR. Molecular docking and ADMET profiling were employed to identify bioactive phytochemicals that target the thyroid-stimulating hormone receptor (TSHR) and Type 2 iodothyronine deiodinase (D2). PTU induction significantly increased thyroid weight (175.8%), TSH levels (4.45-fold), and TPO/TG expression (4.28 and 3.10-fold), while reducing T3 and T4 (82% and 75%; all < 0.05). MEWS treatment (WST-500) significantly reversed these effects, reducing thyroid weight (55.8%), TSH (74.2%), and TPO/TG expression, while restoring T3 and T4 levels to near-normal ( < 0.05). Histopathology revealed reduced fibrosis and improved follicular architecture. A computational study identified phytochemicals with strong binding affinities for TSHR and D2 and favorable ADMET properties. These findings suggest that MEWS may ameliorate hypothyroidism by regulating hormone levels, gene expression, and thyroid morphology, indicating its potential as an adjunct or alternative to conventional hormone replacement therapies for hypothyroidism. - Source: PubMed
Publication date: 2026/04/17
Hossain Md SaudShuvo Md Shah PoranTalukder M Maruf HasanShahidullah Jannat SumaiaNiaz S M RiaduzzamanSohel MdIslam Md Khairul - Background Autoimmune thyroid diseases (AITDs) include Graves' disease and Hashimoto's thyroiditis, embodying a group of complex immune-regulated disorders characterized by a high degree of genetic predisposition. The results from various meta-analyses on AITD-related polymorphisms are still conflicting due to heterogeneity, population-specific effects, and the presence of poor-quality studies.MethodsThis umbrella review aims to merge and critically assess the findings from published meta-analyses to locate the valid genetic risk factors for AITDs. Meta-analyses published between 2005 and 2025 were accessed from databases and estimated using standard evidence-grading frameworks, including AMSTAR-2, GRADE, and the Venice criteria. Evidence was interpreted by integrating pooled effect estimates, heterogeneity, total sample sizes, and subgroup consistency.Results Among the assessed loci, TSHR polymorphisms yielded consistent associations with GD, supported by relatively large sample sizes, low heterogeneity, extensive study volume, and medium-to-high evidence certainty across study groups. CTLA-4 and PTPN22 variants showed heterogeneity-moderated associations with possible ethnicity-dependent effects. In contrast, FOXP3, cytokine genes, VDR, MTHFR, and TG polymorphisms showed unstable or low-certainty evidence, primarily due to high heterogeneity and fewer studies.Conclusion Thus, this study provides a hierarchical framework for interpreting genetic susceptibility in AITDs, helping to prioritize robust loci for functional validation and translational research. - Source: PubMed
Publication date: 2026/04/20
Shibi Anilkumar AnuAjay NithyaVeerabathiran Ramakrishnan - Very little is known about the origins and history of domestic chickens (Gallus gallus domesticus) in northern Europe due to a lack of existing documentary and ancient DNA evidence from this region. Therefore, we conducted ancient DNA analyses and radiocarbon dating of archaeological chicken bones from the Baltic Sea region (Finland, Estonia, and Lithuania). We sequenced a 201-bp long fragment of the mitochondrial control region as well as SNPs (single nucleotide polymorphisms) from the thyroid-stimulating hormone receptor (TSHR) gene and the β-carotene dioxygenase 2 (BCDO2) gene, comparing with modern Finnish and Estonian landrace chickens, as well as with other ancient and modern chickens. All studied ancient chickens belonged to a prevalent E1 mitochondrial haplogroup, except one individual from the Åland Islands (haplogroup B). Allele frequencies differed between ancient Baltic and Finnish chickens from Åland Islands in TSHR and BCDO2 genes, with Åland harbouring more individuals with grey skin. Interestingly, yellow-skinned chickens were more common in mainland Finland and Baltic countries during ancient times than in central and southern Europe. Mitochondrial haplogroup A was present in modern Finnish landrace chickens but not in ancient samples from the early Finnish Iron Age to the early modern period (3-18 century CE), indicating later introgression. Both Estonian and Finnish landrace chickens had a higher frequency of the TSHR wild-type allele than the modern reference samples. Based on our results, the ancient chickens from the Åland Islands differed from other ancient chickens from the Baltic Sea region, and the landrace chickens differ from other modern chickens. - Source: PubMed
Publication date: 2026/04/13
Olli SuviGustavsson RudolfKivikero HannaLõugas LembiMannermaa KristiinaPiličiauskienė GiedrėRannamäe EveSearle Jeremy BKvist LauraHonka Johanna - The thyrotropin receptor (TSHR) mutation can be present in autonomously functioning thyroid nodules (AFTNs). Our objective was to evaluate whether patients with a TSHR mutation developed AFTNs and to assess the impact of this mutation on thyroid malignancy. - Source: PubMed
Publication date: 2026/04/03
Magri AngelaSavoia GianlucaRutenberg Nicholas JAvior GalitZarruk Alexandroda Silva Wurzba Sabrina DanielaPayne Richard JForest Véronique-Isabelle - Choroidal characteristics and nerve structure were evaluated in Graves' disease patients without ocular signs using Ultra-Widefield OCT angiography and compared with healthy controls, and their correlation with TSI was assessed. - Source: PubMed
Publication date: 2026/04/02
Liang JingMao YanDu TaoPeng Juan