Ask about this productRelated genes to: EPOr antibody
- Gene:
- EPOR NIH gene
- Name:
- erythropoietin receptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-14
- Date modifiied:
- 2017-07-12
Related products to: EPOr antibody
Related articles to: EPOr antibody
- Although stimulation of erythropoietin receptor (EPOR) signaling demonstrates cytoprotective effects-including anti-apoptosis, pro-proliferation, and promotion of inflammation resolution-in various disease models, its alterations and specific role in the process of pulmonary fibrosis are still not well understood. The study aimed at investigating the changes of lung EPOR signal in pulmonary fibrosis and the effect of different cell EPOR signal on pulmonary fibrosis. - Source: PubMed
Wu PengfeiJia JialinJin TianrongLuo BangweiZhang ZhirenWang Guansong - Erythroferrone (ERFE), secreted by erythroblasts, is regarded as a classical regulator of iron metabolism through its suppression of hepcidin. Thus, as a consequence of insufficient hepcidin suppression and reduced iron availability, global mice exhibit delayed recovery after phlebotomy. We have shown previously that, apart from erythroblasts, ERFE is notably expressed in osteoblasts. To explore the effect specifically of osteoblast-derived ERFE during stress erythropoiesis, we first created mice, which were then crossed with -Cre mice to generate osteoblast-selective mutants (or -Cre; mice). The induction of stress erythropoiesis in these latter mice by phlebotomy resulted in reduced serum ERFE levels and increased liver (hepcidin) expression. Importantly, -Cre; mice showed a more robust red blood cell (RBC) recovery 6 d postphlebotomy, with no differences in bone marrow relative to mice. Furthermore, despite no differences in the baseline RBC count, reticulocyte count, spleen size, or bone marrow cellularity, osteoblast-selective ERFE loss resulted in enhanced erythropoietin receptor () and bone morphogenetic protein 4 () expression in whole bone in vivo and in osteoblasts ex vivo. Finally, the osteoblast-selective mutants showed erythroid lineage proliferation and enhanced EPO responsiveness in a BMP4-dependent manner. Taken together, we posit that ERFE loss specifically from osteoblasts enhances RBC recovery during stress erythropoiesis-defining mechanisms of regulation in the crosstalk between osteoblasts and erythroblasts. - Source: PubMed
Publication date: 2026/04/28
Na-Phatthalung PinanongCaloen Gabrielle vanPlanoutene MarinaTai EmilyGumerova AnisaWitztum RonitIngber EvaKautz LeonSultana FarhathKorkmaz FundaLevy MaayanYuen TonyZaidi MoneGinzburg Yelena Z - This study aimed to investigate erythropoietin receptor (EPOR) expression in human AKI and to examine its association with histopathological severity and clinical parameters. - Source: PubMed
Publication date: 2026/04/07
Xie KunZhou GangLi MengjinFu LiliWang RongZhang LimingMei ChanglinXue ChengXu Daoliang - This study aims to elucidate the pharmacological basis and antidepressant mechanisms of a combined extract from Eucommia ulmoides Oliv. And Gastrodia elata Bl. (Eucommia-Gastrodia extract), employing an integrated strategy that combines UHPLC-QTOF-MS analysis, network pharmacology, molecular docking, and in vivo validation. - Source: PubMed
Publication date: 2026/03/31
Xue LanqiongPan ZhuoyueLiu YaoGan QiulingLiu DongLiu Dingding - The emergence of tumor cell resistance is one of the major issues in current oncology practice. It reduces the effectiveness of therapy and worsens cancer patients' prognoses. However, it confirms a wide range of molecular interactions as well as the complexity of the human organism. Our previous research confirmed the functionality of the erythropoietin receptor (EPOR) in ovarian and breast cancer cells, as well as its relationship to these cells' sensitivity to specific therapies. The current study demonstrates that EPOR overexpression in human ovarian adenocarcinoma cells A2780 is directly linked to paclitaxel resistance. Furthermore, EPOR overexpression results in morphological changes that vary according to the pattern of EPOR isotypes expressed. In this regard, the most interesting result appears to be the change in the shape of the T clone, which has a tendency to form spheroidal structures. In addition, functional enrichment analysis demonstrated that EPOR-associated differentially expressed genes are involved in several biological and cell processes. Indeed, a T clone with a single 68 kDa EPOR isotype demonstrates significant resistance to paclitaxel therapy and is associated with the upregulation of tubulin beta 6. - Source: PubMed
Publication date: 2026/02/16
Harvanik PavolDanková KristínaSolárová ZuzanaŠemeláková MartinaBhide MangeshSolár Peter