HLA-DPA1 antibody
- Known as:
- Human leukocyte antigen-DPA1 (anti-)
- Catalog number:
- 70r-5980
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- HLA-DPA1 antibody
Related products to: HLA-DPA1 antibody
Related articles to: HLA-DPA1 antibody
- The human leukocyte antigen (HLA) system is the primary determinant of donor selection in allogeneic hematopoietic cell transplantation (HCT) and plays a central role in solid organ transplantation, immune-mediated disease studies, evolutionary population genetics, and immunotherapy. Large-scale sampling of registry participants reflecting major US ancestry groups allows for characterization of the complex landscape of HLA haplotype diversity for the classical HLA class I ( ) and HLA class II ( ) genes. Here we present nine-locus classical HLA allele and haplotype frequency estimates for five broad (Black, White, Asian or Pacific Islander, Hispanic and Native American) and 21 detailed US populations based on 9,671,082 donors with targeted genotyping by DNA-based methods. Frequency estimation used an expectation-maximization (EM) framework specifically adapted to handle mixed-resolution and ambiguous HLA genotyping data. Advancements in next-generation sequencing provide extensive HLA genotyping, offering new insights into the haplotype structure and diversity of the human MHC complex, expanding knowledge especially for HLA class II haplotypes. Population analyses reveal that the most common high-resolution haplotypes are predominantly population-specific, with only three haplotypes shared across the top-100 lists of all five broad population groups, and that Black populations exhibit the greatest nine-locus haplotypic diversity, a pattern that persists after controlling for differences in registry sample size. These frequencies, derived from the largest US cohort to date, support clinical decision-making and research in histocompatibility, immunogenetics, and transplantation and are publicly available at https://zenodo.org/records/17966993 . - Source: PubMed
Publication date: 2026/04/13
Gragert LorenMadbouly AbeerBashyal PradeepWadsworth KimKempenich JaneBolon Yung-TsiMaiers Martin - HLA-DPA1*02:162 differs from HLA-DPA1*02:02:02:01 by one missense nucleotide substitution at position 509 in exon 3 (c.509 C>T). - Source: PubMed
Liang ChaolanYang YanWu YafeiSun Liyan - Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) are serious medical problems worldwide. Today, many researchers believe that genetic variations play a major role in how easily someone gets infected and how the disease progresses over time. Although many genetic association studies have suggested various susceptibility loci, lack of consistent results across studies has limited clinical utility. We performed a comprehensive meta-analysis primarily involving East Asian cohorts. We analysed eight SNPs related to HBV infection and 11 SNPs related to HCC across multiple etiologic subgroups. We found that CD40 rs1883832 and C2 rs9267665 exhibited the strongest associations with susceptibility to HBV infection, with no heterogeneity. We found that HLA-DPA1 rs3077 and HLA-DQB1 rs2856718 were significantly associated with HBV infection susceptibility, though with considerable heterogeneity. In our HCC analyses, we found that certain risk variants are linked to specific causes. These include HBV, HCV, alcohol-related disease, and non-alcoholic fatty liver disease (NAFLD). Each cause seems to have its own genetic factors. Based on these results, our meta-analysis brings together many studies to give a clearer picture of the genetic factors that influence HBV infection and HCC in different etiologic pathways. We found that immune-related genes and HLA class II variants seem to have roles in HBV persistence, while metabolic gene variants are major contributors to HCC risk. - Source: PubMed
Lee So YoonShin Hyoung Doo - The novel HLA-DPA1*02:167 allele, differs from HLA-DPA1*02:10, by one non-synonymous nucleotide substitution in exon 3, codon 96. - Source: PubMed
Gong QiNie YanboZhao ChutingLin YaniRu Kun - - Source: PubMed
Publication date: 2026/03/18
Zhang TengtengBao XiaojingHan YingYuan XiaoniLi YangJiang XueYang TianjieDu DanHe Jun