Ask about this productRelated genes to: NMBR antibody
- Gene:
- NMBR NIH gene
- Name:
- neuromedin B receptor
- Previous symbol:
- -
- Synonyms:
- BB1, BB1R
- Chromosome:
- 6q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-30
- Date modifiied:
- 2016-06-07
Related products to: NMBR antibody
Related articles to: NMBR antibody
- Genetic predisposition to obesity can stimulate an increase in adiposity throughout adulthood. However, the interaction between genetic factors and dietary habits may modify the genetic association with obesity. Thus, this study aimed to investigate the dietary patterns that influence the genetic risk of obesity in a Korean population using a large cohort study and genome-wide association study. - Source: PubMed
Publication date: 2026/02/12
Jang Min-JaeChung SangwonLim KyungjoonShin SangahKim Jun-Mo - Endometriosis is a chronic gynecological disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, causing chronic pain and infertility. Hypoxia plays a significant role in the progression of endometriosis. - Source: PubMed
Publication date: 2025/12/18
Zhao MingqiZhao PanpanWang CaiyiRen DanSong YuxiaLu Xiaoqin - Parkinson's Disease (PD) is a complex neurodegenerative disorder with a largely undefined genetic architecture, particularly regarding the role of rare coding variants. We performed a large-scale exome-wide association study to systematically identify rare genetic risk factors for PD. We analyzed whole-exome sequencing (WES) data from 3,602 PD patients and a strictly defined control group of 145,496 individuals of European ancestry from the UK Biobank. We focused on identifying high-confidence protein-truncating variants (PTVs) and used a rigorous gene-based association analysis to find genes significantly associated with PD risk. Our analysis identified PTVs in nine genes that were significantly more frequent in PD cases. These include three previously reported genes for PD/parkinsonism (ATP5F1C, COMMD9, and OPA1) and six novel genes (RGMB, SNX13, MGST2, NMBR, RCBTB1, and JAG1). Following sensitivity analyses, eight genes remained significant. Functional enrichment analysis highlighted pathways related to Notch binding and glutathione transferase activity. This study significantly expands the known genetic landscape of PD by identifying six novel candidate risk genes. Our findings underscore the importance of rare, high-impact PTVs in PD pathogenesis and provide new avenues for mechanistic research and the development of targeted therapeutics. - Source: PubMed
Publication date: 2025/12/03
Fan YuHu ZhenYan Qin-QinWan Jing-JinLiu Jun - Neuromedin B (NMB) has been implicated in the regulation of female reproductive functions, yet its precise role and underlying mechanisms in ovarian follicular development remain undefined. Granulosa cells (GCs), the principal functional cells within ovarian follicles, directly govern follicular growth and maturation through their proliferation and differentiation. In this study, we explored the regulatory effects and molecular mechanisms of NMB and its receptor neuromedin B receptor (NMBR) on goat GC proliferation. - Source: PubMed
Publication date: 2025/11/19
Xia RongxinZhang QiShao JunhuiWang YuanLv XinyiChen RuiLu ZhenZhang YanliWang FengZhang Guomin - Neuromedin B (NMB) and its receptor NMBR constitute a neuropeptide system implicated in various physiological processes. While previously associated with innate immunity, their precise antiviral action against influenza A virus (IAV) infection have remained poorly defined. Here, we elucidate the function of the NMB/NMBR axis in the host defense against H9N2 influenza virus. We demonstrate that NMB treatment and NMBR overexpression potentiate IFN-β production and restrict viral replication in H9N2-infected A549 cells and mouse lungs. Conversely, NMBR knockdown compromises the antiviral response, diminishing IFN-β expression and enhancing viral propagation. We further show that NMB/NMBR signaling targets the viral non-structural protein 1 (NS1) by upregulating the E3 ubiquitin ligase TRIM25. Mechanistically, NMB/NMBR activation engages a positive feedback loop with the retinoic acid-inducible gene I (RIG-I) pathway, reinforcing RIG-I activation through enhanced K63-linked ubiquitination while transcriptionally repressing the deubiquitinase CYLD. Consequently, this augmented signaling potentiates the JAK-STAT1 pathway, leading to increased STAT1 phosphorylation and elevated expression of interferon-stimulated gene 15 (ISG15). Our findings establish that the NMB/NMBR axis confers protection against H9N2 IAV by amplifying RIG-I-mediated innate immunity and facilitating NS1 suppression, revealing a pivotal neuroimmune mechanism and suggesting a promising target for developing broad-spectrum, host-directed therapeutics against IAV. - Source: PubMed
Publication date: 2025/11/13
Yang GuihongTian ShimaoYang JinyuTang YubingTian KeWang SongBao Yinli