Ask about this productRelated genes to: GPR177 antibody
- Gene:
- WLS NIH gene
- Name:
- Wnt ligand secretion mediator
- Previous symbol:
- C1orf139, GPR177
- Synonyms:
- FLJ23091, MRP, wls, EVI, mig-14
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-08
- Date modifiied:
- 2018-11-09
Related products to: GPR177 antibody
Related articles to: GPR177 antibody
- This paper introduces a new approach that effectively balances the trade-off between the strategic deployment of phasor measurement units (PMUs) with the accuracy of state estimation through a multi-objective paradigm. Utilities can achieve optimal grid visibility and reduce deployment costs by identifying the most critical PMU locations, which leads to the strategic PMU deployment (SDP) problem. The objective function includes SDP, state estimation error, and measurement redundancy. The multi-objective Brown Bear optimization is used to obtain SDP. The weighted least squares (WLS) technique is used for state estimation. The load flow analysis is performed using the Newton-Raphson method, and the state estimation error is obtained by finding the mean square difference between WLS without SDP data and WLS with SDP data. The proposed paradigm provides an improved balance between the SDP with maximum redundancy and the accuracy of state estimation. It is tested using the IEEE 30-bus and Polish 2383-bus systems. The performance metrics employed for evaluation include spread, spacing, and the hypervolume indicator. The results of the proposed paradigm derived from the application of multi-objective brown bear optimization are compared with those from other multi-objective algorithms, demonstrating that brown bear optimization produces better outcomes. The technique for order of preference by similarity to ideal solution multi-criteria decision ranking method is used to validate the performance of the proposed approach compared with other algorithms. The Wilcoxon signed-rank test is used to test the statistical superiority of MBOA compared with other algorithms. - Source: PubMed
Publication date: 2026/04/18
Anand KPrakash TapanLala Himadri - : The clinical utility of summarizing long-term C-reactive protein (CRP) trends with a single mean remains unclear. We systematically characterized annual changes in CRP test volume and CRP level distributions using large-scale laboratory data collected at Dankook University Hospital (2008-2023) across the coronavirus 2019 pandemic period. : Overall, 1,845,258 CRP values were analyzed; annual arithmetic, harmonic, and geometric means were calculated; long-term trends were assessed using weighted least squares (WLS) regression weighted by annual test volume; and temporal changes around the pandemic period were examined using a WLS-based interrupted time-series (ITS) segmented model with a prespecified 2020 break. : The annual test volume rose from 2008 to 2013 and 2019, dropped in 2020, increased in 2022, and declined in 2023. The arithmetic mean showed no long-term trend, whereas the harmonic and geometric means declined. ITS models exhibited no statistically significant immediate level-change term in 2020; however, post-2020 slope changes indicated a decline in the arithmetic mean and attenuation of the prior decline in the harmonic mean. As only four annual observations were available after 2020, these post-2020 trend estimates should be interpreted cautiously. : Within this single-center tertiary-care dataset, different CRP summary measures showed different long-term patterns and post-2020 trend changes, without evidence of an abrupt shift in 2020, suggesting stratum-specific shifts that may be invisible to arithmetic mean-based surveillance. These findings are best interpreted as institution-specific and hypothesis-generating, and broader interpretive or operational implications require validation in multicenter settings with differing case-mix and care structures. - Source: PubMed
Publication date: 2026/04/03
Han Jeong SuJung Bo KyeungJeon Jae-SikKim Jae Kyung - In the least-squares fitting of data of varying precision to functions that are algebraically linear in the adjustable parameters, the correct weights for obtaining optimal results are the pointwise inverse variances σ. These have often been obtained from the sampling statistics of replicate measurements of the uncertain quantity , a procedure that has come to define weighted least-squares (WLS) calibration fitting. Unfortunately, such variance estimates are notoriously imprecise, and in a long-ago Monte Carlo study involving a linear response function and weights ranging over a factor of 5, ordinary least squares (OLS) outperformed WLS for almost every tested set of calibration values and replicates. But there is a better way of obtaining the weights: variance-function estimation. This method relies on the fact that the variances for most physical data follow simple, smooth functions having two or three terms proportional to a constant, , and . Since the replicate data are used collectively to estimate the variance function, the number of statistical degrees of freedom is large enough to achieve good precision in the calibration weights. When variance-function weighting is included in the aforementioned OLS-vs-WLS comparisons, it wins over OLS for almost every combination with = 4-8 values and = 3-5 replicates. Further, of the four ways of weighting in the variance-function fitting, the iterative reweighting method gives the best results, in support of earlier findings. - Source: PubMed
Publication date: 2026/04/12
Tellinghuisen Joel - Wuling San (WLS), a classical formula from Treatise on Febrile Diseases, has significant efficacy in ameliorating the clinical symptoms of chronic kidney disease (CKD) with fluid retention, yet its molecular mechanisms remain unclear. - Source: PubMed
Publication date: 2026/04/10
Zeng ZhijunZhou JieJiang HuilianLiao YonganZhao XipanCao YiwenLao BeiniZhou YuanZhou Jiuyao - Noncanonical Wnt signaling stimulates calcium release and subsequent activation of calcium/calmodulin-dependent protein kinase 2 (CaMKII). We find that CaMKII inhibition decreases Wnt synthesis and identify the downregulation of Wntless (WLS) as the basis for this decrease. WLS transports palmitoylated Wnts to the cell surface, and in the absence of Wnts, it undergoes endoplasmic reticulum (ER)-associated degradation (ERAD). CaMKII inhibition increases proteasome-dependent WLS degradation, which can be suppressed by Wnt overexpression, indicating that CaMKII contributes to ER handling of unliganded WLS and prevention of ERAD. CaMKII inhibition also causes a loss of calnexin, an ER stress response through the activation of PERK, and apoptosis in cells expressing high levels of WLS. Moreover, these effects can be prevented by WLS knockdown. The findings reveal a previously unidentified role for CaMKII in supporting ER chaperone functions. They further show that high levels of unliganded WLS could be a potent driver of ER stress in the presence of CaMKII inhibitors, which may have efficacy in tumors expressing high levels of WLS. - Source: PubMed
Publication date: 2026/04/11
Gu ZhongkaiOwiredu JudeErsoy-Fazlioglu BetulWu BailinLu MichaelBalk Steven PYuan Xin