Ask about this productRelated genes to: GPR177 antibody
- Gene:
- WLS NIH gene
- Name:
- Wnt ligand secretion mediator
- Previous symbol:
- C1orf139, GPR177
- Synonyms:
- FLJ23091, MRP, wls, EVI, mig-14
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-08
- Date modifiied:
- 2018-11-09
Related products to: GPR177 antibody
Related articles to: GPR177 antibody
- Acute kidney injury (AKI) is a critical clinical syndrome with limited curative therapies. Tubular epithelial cell death is a central event in AKI progression in which ferroptosis plays a pivotal role. Pharmacological inhibition of ferroptosis attenuates renal inflammation and preserves kidney function, positioning it as a promising therapeutic strategy for AKI. Wuling powder (WLS) is a classic formula used for kidney diseases; however, whether it confers renoprotection by modulating ferroptosis in AKI remains unclear. - Source: PubMed
Publication date: 2026/09/11
Xiong JingliLong ZiyuMa JiayiJiang HuilianYe JiewenZeng ZhijunLiao YonganLao BeiniZhou YuanYu YangZhou Jiuyao - In Global Navigation Satellite System (GNSS)-denied indoor environments, ultra-wideband (UWB) localization of unmanned ground vehicles (UGVs) is challenged by position-dependent anchor visibility and mixed line-of-sight (LOS)/non-line-of-sight (NLOS) ranging. This study proposes a soft continuous confidence weighting method within an adaptive Kalman filter (AKF)-based UWB/inertial measurement unit (IMU) localization framework. The vehicle model uses motor pulse increments and IMU yaw-rate measurements as inputs and outputs vehicle position and heading estimates. Virtual forward-backward iteration converts inconsistencies between the current UWB ranges and tag-anchor geometry into terminal virtual-anchor displacements. A half-Gaussian function then maps each displacement to a continuous confidence coefficient. The resulting coefficients are incorporated into weighted least-squares (WLS) and AKF localization, while the UWB measurement-noise covariance is adaptively updated using the range innovations. The proposed method was evaluated through static calibration and dynamic localization experiments. These experiments compared soft and hard weighting schemes and assessed the contribution of AKF fusion. These results indicate that the method proposed in this study improves localization accuracy, robustness, and temporal continuity under position-dependent anchor visibility and mixed LOS/NLOS conditions. - Source: PubMed
Publication date: 2026/08/17
Yang YufeiLiu Wei - The Wnt ligand secretion mediator is encoded by WLS, and biallelic variants in this gene have been associated with an ultra-rare syndrome known as Zaki syndrome (ZKS). This study presents the fourteenth documented case of ZKS globally and reviews the clinical and genetic information of previously identified ZKS patients. - Source: PubMed
Publication date: 2026/08/25
Ehtesham NaeimMazaheri MahtaSadr ZahraYavari MahdiehAhrar Hossein - Within a meta-analytic framework, validating surrogate endpoints traditionally requires individual patient data (IPD) from multiple randomized controlled trials (RCTs). This is rarely feasible in rare and indolent diseases. We propose a proof-of-concept strategy that creates synthetic comparative evidence from multiple single-arm trials to enable trial-level surrogacy assessment. - Source: PubMed
Publication date: 2026/08/25
Bommier CDixon J GMaurer M JCerhan J RLambert JShi Q - Front-of-pack labeling (FOPL) is a promising tool to improve consumer understanding of unhealthy foods and reduce diet-related non-communicable diseases (NCDs). However, evidence on the effectiveness of different formats in Bangladesh is limited. - Source: PubMed
Publication date: 2026/07/29
Shamim Abu AhmedTaillie Lindsey SmithHalima OummaBahar NisargaIslam Md HafizulHossain Md MokbulSarwar SnehaAbrar Ahmed KAfroza UmmayChoudhury Sohel RezaSteele LindsayShaheen Nazma