Ask about this productRelated genes to: NPY1R antibody
- Gene:
- NPY1R NIH gene
- Name:
- neuropeptide Y receptor Y1
- Previous symbol:
- NPYR
- Synonyms:
- -
- Chromosome:
- 4q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-22
- Date modifiied:
- 2015-07-22
- Gene:
- NPY6R NIH gene
- Name:
- neuropeptide Y receptor Y6 (pseudogene)
- Previous symbol:
- -
- Synonyms:
- PP2, NPY1RL, NPY6RP
- Chromosome:
- 5q31.2
- Locus Type:
- pseudogene
- Date approved:
- 1997-03-27
- Date modifiied:
- 2018-10-18
Related products to: NPY1R antibody
Related articles to: NPY1R antibody
- Amino acids in the brain modulate eating behavior and energy balance. The aim of the present study was to investigate the effects of DL-methionine (DL-Met), l-lysine monohydrochloride (L-Lys-HCl), and taurine (Tau) on feed intake and the mRNA expression levels of appetite-related hypothalamic neuropeptides in chicks. DL-Met, l-Lys-HCl, or Tau was intracerebroventricularly (ICV) administered to 5-day-old layer-type chicks, and the feed intake was recorded until 1 h post-injection. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of neuropeptide Y (NPY) and its receptors, agouti-related protein (AgRP), pro-opiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), and melanocortin receptors. Our results indicated that injection time and treatment have a significant effect on food intake. Food intake decreased significantly at 30 and 60 min after ICV administration of DL-Met (1.678 μmol), l-Lys-HCl (6.856 μmol), and Tau (5.006 μmol) compared to the control group (P > 0.05). On the contrary, a high dose of each amino acid did not alter feed intake (P > 0.05). The result showed that ICV injection of DL-Met (1.678 μmol) significantly decreased the mRNA expressions of NPY,NPY4R, and NPY6R (P < 0.05), but had no significant effect on the mRNA expressions of NPY1R, NPY5R, and AgRP in the hypothalamus (P > 0.05). Similarly, ICV injection of l-Lys-HCl (6.856 μmol) and Tau (5.006 μmol) significantly decreased mRNA levels of NPY, NPY4R, and NPY6R (P < 0.05), without affecting the mRNA expressions of NPY1R, NPY5R, and AgRP (P > 0.05). DL-Met had no effect on anorexigenic gene expression (P > 0.05). l-Lys-HCl upregulated MC1R (P < 0.05), and Tau upregulated POMC and MC3R (P < 0.05), and both had no influence on CART, MC4R, or MC5R (P > 0.05). The result suggests that both orexigenic and anorexigenic neuropeptide genes are involved in the effects of DL-Met, l-Lys-HCl, and Tau. The effect of DL-Met, l-Lys-HCl, and Tau acts in a dose-dependent manner in the hypothalamus to influence feed intake. - Source: PubMed
Publication date: 2025/07/18
Ghashghaei ElhamWang MinghuiMijiyawa AhmedLin Hai - Neuropeptide Y (NPY) receptors mediate a variety of physiological responses including feeding and vasoconstriction. To investigate the evolutionary events that have generated this receptor family, we have sequenced and determined the chromosomal localizations of all five presently known mammalian NPY receptor subtype genes in the domestic pig, Sus scrofa (SSC). The orthologs of the Y(1) and Y(2) subtypes display high amino acid sequence identities between pig, human, and mouse (92%-94%), whereas the Y(4), Y(5), and y(6) subtypes display lower identities (76%-87%). The lower identity of Y(5) is due to high sequence divergence in the large third intracellular loop. The NPY1R, NPY2R, and NPY5R receptor genes were localized to SSC8, the NPY4R to SSC14, and NPY6R to SSC2. Our comparisons strongly suggest that the tight cluster of NPY1R, NPY2R, and NPY5R on human chromosome 4 (HSA4) represents the ancestral configuration, whereas the porcine cluster has been split by two inversions on SSC8. These 3 genes, along with adjacent genes from 14 other gene families, form a cluster on HSA4 with extensive similarities to a cluster on HSA5, where NPY6R and >13 other paralogs reside, as well as another large cluster on HSA10 that includes NPY4R. Thus, these gene families have expanded through large-scale duplications. The sequence comparisons show that the NPY receptor triplet NPY1R-NPY2R-NPY5R existed before these large-scale duplications. - Source: PubMed
Wraith ATörnsten AChardon PHarbitz IChowdhary B PAndersson LLundin L GLarhammar D