Ask about this productRelated genes to: TRAF7 antibody
- Gene:
- TRAF7 NIH gene
- Name:
- TNF receptor associated factor 7
- Previous symbol:
- RFWD1
- Synonyms:
- RNF119, DKFZp586I021, MGC7807
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-14
- Date modifiied:
- 2015-11-20
Related products to: TRAF7 antibody
Related articles to: TRAF7 antibody
- - Source: PubMed
Publication date: 2026/04/15
García-Bermúdez MGarcía-Bardera JAlarcón-García A DMorales-Fernández LEscribano-Martínez JMartínez-de-la-Casa J MGarcía-Feijoo J - Bladder cancer (BLCA) poses a significant clinical challenge due to its high mortality rates and the inadequacy of current prognostic biomarkers. Programmed cell death (PCD) is crucial in BLCA initiation, progression, and treatment, yet the interplay and specific roles of different PCD pathways in BLCA prognosis remain elusive. This study aimed to develop and validate predictive models by integrating 14 PCD patterns using comprehensive analyses of bulk RNA and single-cell RNA transcriptomic data from TCGA-BLCA and six GEO datasets. Through weighted gene co-expression network (WGCNA) analyses, 24 hub PCD-related genes (PCDGs) were identified in BLCA. Subsequently, we implemented a computational framework that integrated 10 machine learning algorithms along with 101 of their combined permutations. This framework was used to develop a programmed cell death-related signature (PCDRS). The final PCDRS consisted of 12 prognostic genes: P4HB, CHEK2, PTPN2, ATP13A2, CCT6A, TFRC, RRP12, TRAF7, POLR1B, B4GALT3, SIVA1, and TP73.The PCDRS was validated in training and external validation sets, with multivariate analysis confirming its independent prognostic value in BLCA. The PCDRS-integrated nomogram was also developed as a quantitative clinical tool. Furthermore, differences in reactive oxygen species (ROS) levels were observed in the tumor microenvironment between high- and low-risk groups based on PCDRS risk scores. Additionally, the elevated expression and tumorigenic role of P4HB in BLCA were validated through in vitro assays. In summary, P4HB may serve as a candidate gene with potential relevance to BLCA prognosis that could enhance personalized treatment strategies for patients with BLCA. - Source: PubMed
Publication date: 2026/04/02
Cao YangLi CanHua YiboWu TingtingShen QiuyuLin ZeyuHuang Yuhua - - Source: PubMed
Publication date: 2026/04/01
Shi CuijuanZhu WenqiYou NaZhang PeiwenHuang WanlingRen QianWang NanMa Xiaotong - Next-generation sequencing (NGS) has transformed the genetic diagnosis of human diseases, yet many patients remain unsolved due to the complexity of variant interpretation. Manual curation of candidate variants is effective but time-consuming and requires specialized expertise. Artificial intelligence (AI)-driven platforms have emerged as scalable tools for variant prioritization, yet their performance compared with manual curation remains insufficiently evaluated. The aim of this study was to evaluate the performance of AI-driven platforms for variant prioritization in a cohort of patients with inborn errors of immunity (IEI) and to compare their strengths and limitations with manual curation. - Source: PubMed
Publication date: 2026/03/04
Moushib Laith IbrahimMoreno-Ruiz NereaMartín-Nalda AndreaRivière Jacques GUrban BlancaDieli-Crimi RominaPerurena-Prieto JanireAguiló-Cucurull AinaPérez-Estévez ElenaSolanich XavierSoler-Palacín PereColobran RogerBatlle-Masó Laura - TRAF7 mutations are a rare occurrence in human cancer and have recently been described in a group of mesenchymal tumors with varying clinical course. Herein, we expand the spectrum of TRAF7-mutated fibromyxoid spindle cell tumors by reporting the first case to arise in bone. A 60-year-old woman presented with right knee pain and was incidentally found to have a left distal femur lesion, which was first detected 20 years prior when it was favored to be benign. Recent imaging studies revealed significant interval growth with focal cortical destruction and soft tissue extension. Histologic examination showed a bland spindle cell neoplasm with fibrous to myxoid stroma. Rare mitotic figures were present; necrosis and marked cytologic atypia were absent. Immunohistochemical work-up showed that the spindle cells only demonstrated focal cytoplasmic staining with L1CAM, and whole exome sequencing identified a TRAF7 p.Y563C missense mutation. The tumor was resected, and the patient is recovering well at 2 months with no evidence of local recurrence or distant disease. This report is the first known case of a TRAF7-mutated fibromyxoid spindle cell tumor of bone with the longest clinical follow-up reported to date. - Source: PubMed
Warmke Laura MToklu AniRichardson Spencer MCollier Christopher DWurtz L DanielLadd Lauren MShrestha RomanConway Devin J