Ask about this productRelated genes to: OASL antibody
- Gene:
- OASL NIH gene
- Name:
- 2'-5'-oligoadenylate synthetase like
- Previous symbol:
- -
- Synonyms:
- TRIP14, p59OASL, OASL1
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-12
- Date modifiied:
- 2017-09-22
Related products to: OASL antibody
Related articles to: OASL antibody
- Oral stromal and epithelial cells contribute to mucosal inflammation through cytokine-induced chemokine production. Essential oil-containing mouth rinses are widely used as adjuncts to oral hygiene, but whether zinc-containing formulations directly modulate host inflammatory signaling remains unclear. This study investigated the effects of a zinc-containing Listerine formulation on IL-1β/TNF-α-induced inflammatory responses in human oral cells. - Source: PubMed
Publication date: 2026/07/27
Huang XiaoyuPodesser AnnaCengiz Murat İnançGlabonjat Ronald AGruber ReinhardPanahipour Layla - The H9N2 subtype avian influenza virus (AIV) is common in poultry and poses significant risks to both the poultry industry and public health. Current control strategies for H9N2 AIV predominantly rely on vaccination; however, these approaches are often undermined by the continuous antigenic drift of hemagglutinin under the pressure of antibodies. This study evaluated the antiviral efficacy of Siji Antiviral Mixture (SAM) against H9N2 infection in specific pathogen-free chickens. Compared with the infected control group, SAM significantly reduced viral loads in multiple tissues, including liver, spleen, lung, kidney, brain, and trachea, demonstrating its direct antiviral activity. Further analysis revealed that SAM modulated H9N2-induced inflammation by downregulating excessive innate immune responses. Specifically, SAM significantly enhanced the expression of antiviral effectors (OASL and MX-1) in the lungs during the early stages of viral infection, while attenuating the production of inflammatory cytokines (IL-6, IL-10) in the later stages. Additionally, SAM regulated the expression levels of pattern recognition receptors (MDA5, TLR3, and TLR7), thereby preventing excessive immune responses. These findings indicate that SAM possesses both antiviral and immunoregulatory effects, highlighting its potential as an effective anti-AIV agent for the management of H9N2 AIV infection. - Source: PubMed
Publication date: 2026/06/24
Liang YanjiaoYang JingtingJian ChangmaoZhang MiaoxiangChen KeweiYang JunweiLuo PingMo MeilanWei TianchaoHuang TengHuang Jianni - Tonsil-derived mesenchymal stem cells (TMSCs) are widely used in regenerative medicine due to their high proliferative capacity and differentiation potential. However, their origin from immunological gateways exposes them to pathogens, raising concern about viral contamination during cell preparation. Understanding how these pathogens affect the biological and immunological properties of TMSCs is crucial for ensuring the safety and consistency of cell-based therapies. This study evaluated TMSC susceptibility and molecular responses to mammalian orthoreovirus (MRV). - Source: PubMed
Publication date: 2026/07/17
Kim Jeong EunNoh Ji YeongLee Kyeong EunLee Young IlPark JuyunKim Min ChanChoi Da HyeonJung Hye JiJung Hee SungPark Jung WonLee Eun-OkLo Van ThiKim Hye KwonPark Yoon Shin - Porcine epidemic diarrhea virus (PEDV) imposes substantial economic losses on the global swine industry owing to its high pathogenicity and transmissibility. Although arginine (Arg) is known to support the integrity of intestinal barrier, it is not clear whether Arg can alleviate intestinal injury induced by PEDV. A total of 32 healthy 7-day-old piglets were randomly assigned to four groups (Control, Arg, PEDV, PEDV + Arg; eight replicates per group). From day 5, piglets in the Arg and PEDV + Arg groups were orally administered Arg at 400 mg/kg body weight until day 11; then, PEDV (1 × 10 TCID) was given orally for two PEDV-infected groups. On day 14, all piglets were slaughtered to obtain blood and intestine samples for further analysis. The results showed that PEDV infection significantly reduced T-SOD and CAT activities in plasma and intestine while elevating MPO levels. Arg supplementation restored T-SOD (plasma, duodenum, ileum), CAT (plasma, ileum), and GSH-Px (jejunum, ileum) activities and reduced MDA (jejunum) content in PEDV-infected piglets. Hematological analysis showed Arg alleviated PEDV-induced increases in MCV and RDW-SD, and significantly elevated MCHC. The real-time quantitative PCR analysis demonstrated that Arg further enhanced PEDV structural genes (, , ) expression in the duodenum, ileum, and colon. Concurrently, Arg significantly up-regulated interferon-stimulated genes () in the ileum, in the duodenum and colon, and in the ileum. Arg also down-regulated the pro-inflammatory cytokines and and the antimicrobial peptide in the colon, while up-regulating the tissue repair gene in the ileum. In conclusion, oral Arg exhibits a unique dual role: it promotes PEDV replication to a certain extent while significantly enhancing antioxidant capacity, strengthening intestinal antiviral immunity, and attenuating intestinal inflammation. These findings highlight Arg's role in promoting disease tolerance and offer a novel perspective for nutritional intervention strategies against PEDV infection. - Source: PubMed
Publication date: 2026/06/30
Zhang ZhiweiDu YunlongJian RongrongLi HanboLi ZhonghuaLi PengWang LeiZhao DiYi DanWu TaoWu MengjunHou Yongqing - Multiple sclerosis (MS) is increasingly recognized across Gulf Cooperation Council (GCC) countries, where rising disease burden intersects with distinctive ancestry, family structure, consanguinity patterns, vitamin D deficiency, rapid environmental transition, and an unevenly developed genetic literature. Most global MS genetic models have been derived from European-ancestry datasets and may not fully capture susceptibility patterns, allele frequencies, familial structure, or gene-environment interactions in Arabian Gulf populations. A regionally focused synthesis is therefore needed, while recognizing that the available GCC evidence remains too limited, heterogeneous, and insufficiently replicated for conventional pooled meta-analysis. - Source: PubMed
Publication date: 2026/06/29
Alsharoqi Isa AhmedAlsharoqi Abdulla I SalemBohlega Saeed A