Ask about this productRelated genes to: OASL antibody
- Gene:
- OASL NIH gene
- Name:
- 2'-5'-oligoadenylate synthetase like
- Previous symbol:
- -
- Synonyms:
- TRIP14, p59OASL, OASL1
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-12
- Date modifiied:
- 2017-09-22
Related products to: OASL antibody
Related articles to: OASL antibody
- Growing evidence has shown that Mind-Body Transformations-Therapies (MBT-T) are able to modulate chronic inflammation, a well-known driver of cancer progression and drug resistance. In our previous work, we showed that a specific MBT-T protocol was able to reduce the release of various pro-inflammatory cytokines and chemokines in the sera of patients with breast cancer that completed adjuvant chemotherapy. Despite these clinical observations, the underlying molecular pathways through which this therapy exerts its effects remain unclear. This study aims to address this gap by characterizing genome-wide transcriptional profiles in patients undergoing a novel MBT-T protocol. - Source: PubMed
Publication date: 2026/09/11
Cocco StefaniaCozzolino MauroPiezzo MichelaCelia GiovannaBarberio DanielaAbate ValentinaCalabrese AlessandraVon Arx ClaudiaDi Rienzo RossanaCostantini SusanBudillon AlfredoDe Laurentiis Michelino - Atopic dermatitis (AD) is characterized by pruritus, epidermal hyperplasia, and lichenification that significantly impairs quality of life. Nemolizumab, an anti-IL-31Rα monoclonal antibody, is approved for treating moderate-to-severe AD in patients aged > 12 years. This study investigated nemolizumab's molecular mechanisms using patient samples from the ARCADIA 1 (NCT03985943) and 2 (NCT03989349) trials. - Source: PubMed
Publication date: 2026/09/04
Liu DanielDuca Ester DelDelaleu NicolasLau MeganPulsinelli Julianade Rosa Joel CorreaBar JonathanEstrada YerielGudjonsson JohannJulia ValerieGuttman-Yassky Emma - Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited therapeutic options. Here, we identify long-chain acyl-CoA synthetase 5 (ACSL5) as a key oncogenic driver and prognostic biomarker in PDAC. Combined transcriptomic analysis of 51 PDAC samples and three public databases (GSE183795, GSE28735, GSE62452) reveals that ACSL5 is markedly upregulated in PDAC, and its overexpression is significantly associated with shorter patient survival and high diagnostic accuracy (AUC = 0.899), suggesting robust diagnostic potential. Functional assays demonstrate that ACSL5 promotes PDAC cell proliferation, migration, and tumor growth while inhibiting apoptosis. Mechanistically, ACSL5 activates the JAK1-STAT1 signaling pathway, leading to transcriptional upregulation of oligoadenylate synthetase-like protein (OASL). The ACSL5-OASL axis concurrently suppresses PINK1/Parkin-mediated mitophagy and enhances ferroptosis resistance by modulating GPX4, SLC7A11, and ACSL4 expression. Notably, the mitophagy activator CCCP effectively reverses ACSL5-driven tumor progression and restores ferroptosis sensitivity. Our findings establish ACSL5 as a promising diagnostic and therapeutic target and reveal that targeting mitophagy represents a potential strategy for ACSL5-high PDAC. - Source: PubMed
Publication date: 2026/09/03
Dong JingjingDai MengtingZhou YimingWu MengdeWu WeiZhou LinlingJi ZhaoyangYe TongtongQin JiayingLuo JialuYu ChenhuanXu Mingzhi - Gliomas are highly aggressive primary brain tumors with a dismal prognosis. Temozolomide (TMZ) serves as the first-line chemotherapeutic agent for glioma patients. However, the clinical efficacy of TMZ is severely limited by the inevitable development of acquired chemoresistance, which ultimately leads to tumor recurrence and treatment failure. Unraveling the molecular mechanisms underlying TMZ resistance is therefore critical for improving glioma prognosis. This study aimed to identify key genes driving TMZ resistance and explore their underlying mechanisms to provide novel therapeutic targets for overcoming this clinical challenge. - Source: PubMed
Publication date: 2026/08/15
Fan YiYang HeYu Hai - Oral stromal and epithelial cells contribute to mucosal inflammation through cytokine-induced chemokine production. Essential oil-containing mouth rinses are widely used as adjuncts to oral hygiene, but whether zinc-containing formulations directly modulate host inflammatory signaling remains unclear. This study investigated the effects of a zinc-containing Listerine formulation on IL-1β/TNF-α-induced inflammatory responses in human oral cells. - Source: PubMed
Publication date: 2026/07/27
Huang XiaoyuPodesser AnnaCengiz Murat İnançGlabonjat Ronald AGruber ReinhardPanahipour Layla