Ask about this productRelated genes to: SOCS1 antibody
- Gene:
- SOCS1 NIH gene
- Name:
- suppressor of cytokine signaling 1
- Previous symbol:
- -
- Synonyms:
- SOCS-1, SSI-1, JAB, TIP3, Cish1
- Chromosome:
- 16p13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2015-08-26
Related products to: SOCS1 antibody
Related articles to: SOCS1 antibody
- Type 1 diabetes (T1D) is characterized by the autoimmune destruction of pancreatic beta cells. While most beta cells are lost, a subset of beta cells persists years and even decades after disease onset. Studying these surviving cells is challenging, and thus how they escape immune killing remains poorly understood. Here, we applied a gene regulatory network inference-based clustering approach on existing islet scRNAseq data from cadaveric donors with T1D, autoantibody positive donors at risk for T1D, and non-diabetic donors to analyze beta cells from patients with established T1D. This approach identified a novel beta cell subtype enriched in T1D donors defined by the activity of several transcription factors which have well-characterized roles in beta cell survival, most notably IRF1. We found increased expression of immunomodulatory genes (e.g. ) as well as decreased expression of autoantigens and secretory genes, suggesting dedifferentiation. We identified inflammatory cytokines as a driver of this phenotype by reanalyzing public data from primary human beta cells stimulated with inflammatory cytokines in vitro. We additionally find a similar transcriptional program active in a subset of alpha cells, consistent with cell-extrinsic inflammatory cytokine signaling in vivo. Overall, we propose that this population represents a resilient beta cell phenotype, and that the transcriptional program active in these cells may identify targets for T1D prevention and reversal. - Source: PubMed
Publication date: 2026/05/27
Spurrell MaxwellTsang John SHerold Kevan C - To investigate the expression levels of suppressor of cytokine signaling 1 ( ) and 3 () in patients with myelodysplastic syndrome (MDS) and assess their clinical significance. - Source: PubMed
Zhang Yong-XiaoWu YanShi RuiWang QianWang Dong-MeiLi Ying-Hua - Polycystic ovarian syndrome (PCOS) is associated with low-grade systemic inflammation and an increase in inflammation markers, which are crucial in managing ovarian function. This study aimed to determine whether gene variants are associated with PCOS risk. In total, 300 subjects were enrolled (150 patients with PCOS and 150 healthy individuals). Each subject's peripheral blood was collected for genomic DNAs isolation and biochemical assessments. After adjustment for BMI, codominant heterozygous [OR = 0.45, 95%CI = 0.27-0.77], codominant homozygous [OR = 0.29, 95%CI = 0.11-0.76], dominant [OR = 0.39, 95%CI = 0.23-0.65], and overdominant [OR = 0.50, 95%CI = 0.29-0.84] models of rs33932899, as well as the codominant homozygous [OR = 0.26, 95%CI = 0.10-0.69], dominant [OR = 0.55, 95%CI = 0.34-0.89], and recessive [OR = 0.33, 95%CI = 0.12-0.87] genetic patterns of rs243327 were significantly associated with decreased PCOS risk. On the contrary, codominant homozygous [OR = 2.40, 95%CI = 1.20-4.78] and recessive [OR = 2.10, 95%CI = 1.14-3.87] modes of the rs33989964 variation increased PCOS risk (P-value < 0.05). Analysis of the interaction demonstrated that the GG/Del-Del/CC genotype combination of rs33932899/rs33989964/rs243327 significantly increased the risk of PCOS in our population [OR = 4.81, 95%CI = 1.72-13.49]. Furthermore, the GTGC and CDelC and CDelT haplotypes were associated with the risk of PCOS ( = 0.007, < 0.001 and = 0.012 respectively). A significant difference has also been observed between cases carrying GG + GC genotypes of rs33932899 regarding fasting blood sugar levels (P-value < 0.05). The rs33989964 variation increased PCOS risk, while both rs33932899 and rs243327 variants conferred protection against PCOS in our population. Additional research on various racial groups is needed to determine if these variations contribute to PCOS, a complicated hormonal disorder with multiple factors. - Source: PubMed
Publication date: 2024/07/10
Rakhshanizade NiloufarSargazi SamanKarajibani MansourMajidpour MahdiKarajibani AtenaMontazerifar FarzanehGhasemi Marzieh - While electroacupuncture has been shown to improve renal injury associated with salt-sensitive hypertension, its mechanism of action requires elucidation. This study sought to elucidate the epigenetic regulation involved, specifically investigating how electroacupuncture modulates the JAK2/STAT3 inflammatory pathway through SOCS1 methylation in a salt-sensitive hypertensive rat model. - Source: PubMed
Publication date: 2026/05/28
Wen JianDai ZifengWang YutingYan HongyuYue YanyuYao RuiqiMa KaixuanHou LinruRen YiZhang Lili - This letter highlights diagnostic importance of considering monogenic immune dysregulation in complex allergic and autoimmune diseases. Additionally, the report expands on the clinical spectrum of suppressor of cytokine signaling 1 insufficiency (SOCS1 insufficiency) by identifying severe, treatment-refractory eosinophilic asthma as a novel primary manifestation. - Source: PubMed
Publication date: 2026/04/09
Murray CliodhnaHarrison Michael JLeahy Timothy RLee-Brennan Caríosa