Ask about this productRelated genes to: RGS6 antibody
- Gene:
- RGS6 NIH gene
- Name:
- regulator of G protein signaling 6
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-17
- Date modifiied:
- 2017-04-13
Related products to: RGS6 antibody
Related articles to: RGS6 antibody
- Platelet activation via G protein-coupled receptors (GPCRs) is central to arterial thrombosis. P2Y12 is a canonical Gi-coupled receptor mediating ADP-dependent platelet activation, yet the role of Regulator of G protein Signaling 6 (RGS6), a modulator of Gi signaling, in platelet function and thrombosis remains unclear. - Source: PubMed
Publication date: 2026/04/30
Roytenberg RenatRorabaugh Boyd RYue HongJividen RobbieCameron Scott JLi Wei - Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self-identifying as Hispanic. Population-specific results enable personalized and equitable interventions. Ethnicity as a stratifier co-occurs with genomic inflation due to heterogeneity. - Source: PubMed
Willett Julian Daniel SundayWaqas MohamadNaumenko SerhiyMullin KristinaHecker JulianBertram LarsLange ChristophVlachos IoannisHide WinstonTanzi Rudolph EProkopenko Dmitry - Non-coding RNAs (ncRNAs) play crucial roles in the regulation of gene expression, but their genetic underpinnings and roles in human traits and diseases remain largely elusive. Here, we identified 38,441 long non-coding RNAs (lncRNAs) and 23,548 circular RNAs (circRNAs) from RNA sequencing (RNA-seq) data of 2,865 human cortex samples, of which 27,453 lncRNAs and all circRNAs were not reported in GENCODE. Expression quantitative trait locus (eQTL) analyses identified cis-eQTLs for 15,362 lncRNAs and 1,312 circRNAs. We showed that lncRNA- or circRNA-eQTLs were largely independent of, and had larger effects on average than, eQTLs of their adjacent or parental protein-coding genes (PCGs). The circRNA-eQTLs were highly enriched in canonical splice sites, highlighting the crucial role of back-splicing in circRNA biogenesis. LncRNA-eQTLs were enriched for heritability of brain-related complex traits and associated with 72 (11.2%) of the colocalized genome-wide association study (GWAS) signals that showed no evidence of colocalization with PCG-eQTLs or splicing quantitative trait loci (QTLs) identified in the same dataset. We showcased lncRNAs (e.g., those near VPS45, MAPT, and RGS6) and circRNAs (e.g., that for GRIN2A) that may be implicated in complex traits through genetic regulation of ncRNAs. Our study provides insights into the genetic regulation of ncRNAs and their implications in brain-related complex traits. - Source: PubMed
Publication date: 2025/12/16
Chen LiGuo YazhouHou JunrenYang WenQi TingYang Jian - The primate striatum and its principal neuron type, the medium spiny neuron (MSN), integrate cortical and subcortical signals related to movement, cognition, and emotion. These signals are processed through cell type specific circuits traditionally defined by MSN dopamine receptor expression. However, classification by dopamine receptor type alone fails to fully specify MSN diversity and falls short of capturing the functional complexity of the striatum. Here, we combined single-nucleus multi-omic sequencing and high-plex spatial transcriptomics to build a comprehensive atlas of MSNs in the macaque striatum. Using multi-omic sequencing, we profiled MSNs across four anatomically and functionally defined territories, and we mapped these subtypes back into their anatomical context by integrating the multi-omic data with ~5.4 million spatially resolved cells sampled across the full rostral-caudal and dorsal-ventral extent of the striatum. This approach revealed two previously undocumented ventral striatum (VS) subtypes, D1-VS-RGS6 and D2-VS-RGS6, which are molecularly distinct from known ventral striatal MSNs yet share core limbic features. We also uncovered gradients in matrix-compartment cell types along the rostral-caudal axis. Finally, by integrating MSN subtype-specific transcriptomes and ATAC-seq-derived regulatory annotations with human GWAS data, we demonstrate strong, cell-type-specific enrichment of polygenic risk for Parkinson's disease, substance use disorders, and psychiatric and cognitive traits, including a striking association of D2-VS-RGS6 with schizophrenia and bipolar disorder. Together, this multimodal atlas provides a foundation for linking primate striatal cell types to circuit function and disease mechanisms. - Source: PubMed
Publication date: 2025/11/19
Abdelhady GhadaBrull Olivia RHe JingLin Meng KGalvan AdrianaPfenning Andreas RBostan Andreea CStauffer William R - The transcription of enhancer RNA (eRNA) marks enhancer activity and may confer context-dependent regulatory functions, yet its underlying mechanism remains elusive. Leveraging BrainSeq data, we constructed ancestry-stratified expression quantitative trait locus (eQTL) maps for 71,022 transcriptional non-coding enhancer (TNE) RNAs. By integrating the latest Psychiatric Genomics Consortium (PGC3) schizophrenia GWAS with European-ancestry population-based eQTLs via Summary-data-based Mendelian Randomization (SMR), we identified 61 schizophrenia-risk TNEs, 19 of which overlapped with those from differential expression (DE) analysis. Intriguingly, for 19 overlapping TNEs, effects from DE analysis were inversely correlated with SMR effects (r = -0.57, P = 0.01), attributable to the opposing contributions of phenotype and genotype to TNE expression (r = -0.78, P = 2.96E-3). We further linked this discrepancy to reduced levels of the repressor ZNF135 in schizophrenia, which derepressed motif-matched TNEs. Finally, we identified and experimentally validated that an enhancer RNA within the intronic region of RGS6, termed RGS6e, regulates the expression of genes associated with the nervous system through trans-acting mechanisms, promoting neuronal differentiation and thereby reducing the risk of schizophrenia, consistent with the SMR results. This study underscores the significance of eQTL-based SMR analysis in elucidating the role of enhancers and their transcriptional products in schizophrenia risk. The eQTL map of TNEs developed in our study holds considerable potential for application in enhancer research related to other mental diseases or neurodegenerative diseases, thereby enhancing our understanding of how enhancers contribute to disease pathogenesis and progression. - Source: PubMed
Publication date: 2025/11/23
Ye LinyanNi ChaoyingChen RenhaoChe SiyaoXiong FuZhao CunyouWang Zhongju