Ask about this productRelated genes to: IFIT5 antibody
- Gene:
- IFIT5 NIH gene
- Name:
- interferon induced protein with tetratricopeptide repeats 5
- Previous symbol:
- -
- Synonyms:
- RI58
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-06
- Date modifiied:
- 2015-11-27
Related products to: IFIT5 antibody
Related articles to: IFIT5 antibody
- Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molecular drivers remain unclear and better risk prediction is urgently needed. Using transcriptomics, single-cell analysis, and genetic data, we investigated the role of N7-methylguanosine (m7G) RNA modification in IA. We identified distinct m7G modification patterns, validated their methylation features in patient samples, and incorporated these patterns into a machine learning-based rupture prediction model. The presence and characteristics of m7G patterns significantly improved model performance, achieving high predictive accuracy across three independent cohorts (AUC 0.91-0.95). Genetic analyses further identified three causal m7G-related genes (NSUN2, IFIT5, SNUPN), and laboratory experiments confirmed their altered expression and methylation in ruptured aneurysms. Overall, our findings demonstrate that m7G modifications play a key role in IA rupture. The validated prediction model offers strong clinical potential for rupture risk assessment, and the identified genes represent promising therapeutic targets. - Source: PubMed
Publication date: 2026/03/12
Wu PengfeiMaimaiti AierpatiMa ZekunAbulizi AlimasiYang WenboYin ShengnanWang YongxinWang Zengliang - Atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) are highly prevalent conditions that significantly impact patient outcomes. While mounting evidence suggests a strong epidemiological and clinical association between AF and COPD, the molecular basis underlying their frequent co-occurrence remains incompletely characterized. Rather than inferring direct disease-specific mechanistic links, this study aimed to identify shared systemic inflammatory and immune-related transcriptional signatures that are detectable across different tissues in AF and COPD. - Source: PubMed
Publication date: 2026/03/11
Zhou WeiTang QianChen DandanChen JiulinShi LinyanLuo FuliangYan FeiMao YifanLu HuiminZhou XingChen ZhangrongLi Wei - sp., a marine microalga amenable to mass cultivation, possesses antiviral properties, partly attributed to chlorophyll a. However, the underlying antiviral mechanisms remain poorly characterized. In this study, we investigated the antiviral activity and mode of action of chlorophyll a derived from sp. by performing transcriptomic analyses on three experimental groups: untreated, uninfected cells; Zika virus (ZIKV)-infected cells; and chlorophyll a-treated, ZIKV-infected cells. Treatment with 5 µM chlorophyll a induced differential expression of genes associated with interferon-inducible antiviral responses. Gene ontology analysis revealed significant enrichment of biological processes such as "response to external stimulus" and "response to biotic stimulus." Notably, Venn diagram analysis of 130 differentially expressed genes (DEGs) demonstrated restoration of key interferon-stimulated genes, including interferon-induced protein with tetratricopeptide repeats (IFIT)1, IFIT2, IFIT3, and IFIT5, which was further validated by quantitative PCR and immunocytochemistry. These findings suggest that chlorophyll a from sp. exerts antiviral effects primarily through modulation of interferon-mediated pathways. See also the graphical abstract(Fig. 1). - Source: PubMed
Publication date: 2026/01/09
Kang NalaeKim Eun-ALee Yeon-JiHeo Seong-YeongHeo Jun-HoLee Won-KyuRyu Yong-KyunKim TaehoHeo Soo-Jin - Marek's disease virus (MDV) is a highly contagious oncogenic alphaherpesvirus that continues to threaten global poultry production, highlighting the need for next-generation vaccines. Although in ovo delivery of conventional MDV vaccines has been effective, vaccine leakiness has accelerated viral evolution by promoting the selection of more virulent, immune-evasive strains. mRNA vaccines offer a flexible and rapidly adaptable platform capable of inducing potent immune responses, yet their application against MDV remains unexplored in the in ovo context. Here, we report the first in ovo administration of a bivalent MDV mRNA vaccine encoding glycoprotein B (gB) and phosphoprotein 38 (pp38). RNA sequencing of the spleen and bursa of Fabricius at 12-, 24-, and 48-hours post-vaccination revealed distinct, time- and tissue-specific transcriptional programs. In the spleen, differential expression analysis (fold-change ≥ 2, padj < 0.05) demonstrated early activation of caudal-type homeobox 1 (CDX1) and signal transducer and activator of transcription 1 (STAT1), together with interferon-stimulated antiviral genes MX dynamin-like GTPase 1 (MX1), 2'-5'-oligoadenylate synthetase-like (OASL), and interferon-induced protein with tetratricopeptide repeats 5 (IFIT5). In contrast, the bursa exhibited persistent modulation of colipase (CLPS), chymotrypsinogen B1 (CTRB1), and deoxyribonuclease I (DNASE1), indicating metabolic and apoptotic remodeling. These results demonstrate that in ovo mRNA vaccination against MDV rapidly activates organ-specific immune and metabolic pathways, providing a transcriptomic framework for the rational design of poultry mRNA vaccines. - Source: PubMed
Publication date: 2025/12/26
Shoja Doost JananYitbarek AlexanderWootton Sarah KBehboudi ShahriarSharif Shayan - Prediction of outcomes of SARS-CoV-2 infection remains challenging, particularly in the early days following exposure. To better understand the heterogeneity of disease progression, we investigated the early immune response in the upper respiratory tract using transcriptomic analysis, comparing individuals who remained asymptomatic to those who developed symptoms of COVID-19. We conducted a study of 74 individuals (43 children, 31 adults) with confirmed SARS-CoV-2 infection. Mid-turbinate nasal swabs were collected during the first few days of infection and again one week later. We performed a paired analysis comparing baseline and follow-up nasal human gene expression. Additionally, we conducted a predictive analysis to identify transcripts associated with the development of symptomatic infection. From the differentially expressed transcripts in both analyses, we developed a predictive model to assess the likelihood of symptomatic disease. We also compared gene expression patterns between children and adults. A robust interferon response in the upper respiratory tract was strongly associated with the development of symptomatic infection. A panel of five interferon-stimulated genes (TAP2, DDX60, IFIT5, APOL6, and IFI6) predicted symptomatic infection with reasonable accuracy (area under the curve = 0.84). Notably, adaptive immune responses, including T-cell activation and cytokine signaling, differed substantially between children and adults. Our findings suggest that early measurement of interferon-stimulated gene expression may help identify individuals at risk of developing symptomatic COVID-19. - Source: PubMed
Publication date: 2025/12/05
Yue MolinLee SojinTao ShiyueTomazetto GeizeclerYahner KristinLiu HuiLee Matthew CNowalk Mary PatriciaZimmerman Richard KJohnson MonikaMacDonald WilliamForno ErickChen WeiShaikh Nader