Ask about this productRelated genes to: CD160 antibody
- Gene:
- CD160 NIH gene
- Name:
- CD160 molecule
- Previous symbol:
- -
- Synonyms:
- BY55, NK1, NK28
- Chromosome:
- 1q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-02
- Date modifiied:
- 2016-10-05
Related products to: CD160 antibody
Related articles to: CD160 antibody
- Immune checkpoint inhibitors (ICIs) have improved outcomes for patients with melanoma and are now the standard of care for high-risk and advanced disease. However, long-term benefits are observed in only around 25% of patients, with significant risk for immune-related adverse events, highlighting the need for predictive biomarkers. To develop a minimally invasive, pre-treatment biomarker strategy, we profiled functional and subset-specific transcripts in peripheral blood T lymphocytes (PBTLs) and applied machine learning to identify predictive signatures. Patients were enrolled prior to receiving ICI monotherapy in the adjuvant (Exploratory n=61, Validation=78) or metastatic (Exploratory n=48, Validation=46) settings. Following feature selection, random forest models were trained and benchmarked against empirical null models. In the adjuvant setting, CD160 and GZMB predicted recurrence (95th percentile), while treatment-limiting toxicity was predicted by a signature comprising TNFRSF18, VTCN1, TIGIT, CCR4, and AHR (97th percentile). In the metastatic setting, baseline CD45RB, a marker of T-cell differentiation, most strongly predicted progression within one year (93.9th percentile). Distinct signatures in the adjuvant and metastatic settings suggest differences in T-cell programs associated with patient outcomes. These findings support further evaluation of pre-treatment circulating T-cell transcriptional profiles as predictors of ICI response and toxicity in melanoma. - Source: PubMed
Publication date: 2026/08/25
Lepola NoahDravillas CarolineGray ShannonBodnar Michael SArya NamrataWu RichardVerschraegen ClaireCarson William EKendra Kari LSpakowicz Daniel JBurd Christin E - Regulatory T cells (Treg) play a central role in maintaining immune homeostasis, and the implementation of in vitro induced Treg cells (iTreg) to control immune function has significant potential in clinical medicine. The clinical application of iTreg has been limited by their poor stability. To better define the molecular characteristics of human iTreg, we performed a data-independent acquisition proteomics, detecting over 8000 proteins and providing a quantitative comparison of their relative levels in iTreg and activated Th0 cells. Consistent with the known molecular characteristics of Treg, several Treg signature proteins, including FOXP3, IKZF4, IL2RA, CTLA4, PD-1, IKZF3, LAG3, RUNX1 and HIC1, were identified and validated using Tier 2 targeted SRM and/or qRT-PCR. Notably, Leupaxin (LPXN) level was upregulated during Treg cell differentiation. Functional studies demonstrated that LPXN-deficient cells showed impaired expression of Treg protein markers FOXP3, IKZF4 and IKZF3 and impaired suppression of effector T cells. In addition, we identified a distinct CD160 iTreg subpopulation characterized by a distinct proteomic signature as compared to CD160 iTreg. Together, these findings provide a high-resolution proteomic landscape of human iTreg and identified a novel role of LPXN in the development and suppressive activity of iTreg. - Source: PubMed
Publication date: 2026/08/20
Batkulwar KedarAndrabi Syed Bilal AhmadKattelus RoosaBuchacher TanjaArnkil IlonaStarskaia InnaRasool OmidMoulder RobertLahesmaa Riitta - Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening hyperinflammatory syndrome paradoxically characterized by excessive cytokine production and immune activation despite failure to clear Epstein-Barr virus (EBV). The cellular mechanisms underlying immune dysregulation in EBV-HLH remain incompletely understood. - Source: PubMed
Publication date: 2026/08/05
Luo XiaodanChen AoLiu JianboShi BoyunTang JianliHuang JiayuYuan DanyunLiang ZhimingTan HuoZheng Runhui - Immune checkpoint inhibitors (ICIs) have improved cancer outcomes; however, many patients fail to respond, highlighting the need for novel targets. HVEM (Herpes Virus Entry Mediator) is an immune regulator with both inhibitory and stimulatory functions, making it a promising therapeutic candidate. We have developed Anti-4CB1, a fully human monoclonal antibody (mAb) that selectively blocks HVEM interactions with BTLA and CD160. Its activity was evaluated in-vitro using human tumor-infiltrating lymphocytes (TILs), peripheral blood mononuclear cells (PBMCs), and M1 macrophages, as well as in ex-vivo patient-derived tumor samples and in-vivo transgenic and humanized mouse models. HVEM expression was also assessed in serum and tumor tissues. Anti-4CB1 enhanced T-cell activation and cytotoxicity, evidenced by increased tumor cell killing, upregulation of activation markers (41BB, CD107a), and elevated IFNγ and TNFα secretion. It also promoted macrophage-mediated phagocytosis. In ex-vivo analyses of 49 patient-derived tumor samples, Anti-4CB1 increased cytotoxicity in 28.5% of cases, including samples unresponsive to anti-PD1. In-vivo, Anti-4CB1 demonstrated significant anti-tumor activity as monotherapy and showed enhanced efficacy in combination with anti-PD1. Additionally, higher tumor HVEM expression correlated with improved response to checkpoint blockade, while elevated soluble HVEM levels were associated with reduced responsiveness to Anti-HVEM. Anti-4CB1 enhances both adaptive and innate anti-tumor immunity and shows activity in anti-PD1 resistant settings. These findings support its potential as a novel therapeutic agent and suggest HVEM as a predictive biomarker for immunotherapy response. - Source: PubMed
Publication date: 2026/08/19
Galore-Haskel GilliMerhavi-Shoham EfratShapiro MikaBareli RoniDror NaamaSeliktar-Ofir SivanShamalov KaterinaLandstein DoritLevy-Barda AdvaHout-Siloni GoniSchachter JacobSadot EranEitan RamBarshack IrisGolan ShayFeferman YaelYeoshoua EffiEyadat SaebGreenberg EyalMarkel Gal - CD244, expressed in the tumor microenvironment (TME), is associated with impaired function of natural killer (NK) and T cells; however, its role in diffuse large B-cell lymphoma (DLBCL) remains poorly understood. This study aimed to elucidate the immunological significance and regulatory mechanisms of CD244 in DLBCL. - Source: PubMed
Publication date: 2026/07/07
Yang YimingZeng BiyangYang HuiminLiu XinLi PeilinMai ChaoJian ShunhaiZhu Qiqi