Ask about this productRelated genes to: DGKH antibody
- Gene:
- DGKH NIH gene
- Name:
- diacylglycerol kinase eta
- Previous symbol:
- -
- Synonyms:
- DGKeta
- Chromosome:
- 13q14.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-16
- Date modifiied:
- 2016-10-05
Related products to: DGKH antibody
Related articles to: DGKH antibody
- Kidney stone disease (KSD) is multifactorial, and the genetic basis is poorly understood among the East Asian population. This study aims to elucidate comprehensive genetic factors associated with KSD. - Source: PubMed
Publication date: 2026/06/15
Chen Chun-YiLee SunyeopLin Chi-MawTsai Chung-YouWu Chia-ChangLin Yu-FengHo Chen-HsunHuang Shin-YauHsu Wan-TingLee Chien-Chang - Metabolic disorders represent a global health challenge requiring novel therapeutic strategies targeting the gut-liver axis. This study investigates the protective effects and mechanisms of lentinan, a bioactive polysaccharide from , against high-fat diet (HFD)-induced metabolic dysfunction. HFD-fed mice were treated with lentinan. Comprehensive phenotypic assessments, metagenome sequencing, hepatic transcriptomics, and correlation analyses were performed to elucidate mechanisms. Lentinan intervention significantly ameliorated dyslipidemia, hepatic steatosis, systemic inflammation, and intestinal barrier dysfunction in HFD-fed mice. Mechanistically, lentinan induced taxonomically selective gut microbiota remodeling, characterized by substantial enrichment of (positively correlated with hepatic expression) and reduction of (negatively correlated with and ), while paradoxically decreasing despite metabolic improvements. Hepatic transcriptomics revealed significant downregulation of glycerolipid metabolism and oxidative phosphorylation pathways, directly correlating with reduced lipid accumulation and improved serum biochemistry. Unlike conventional prebiotics, lentinan functions as a precision modulator of specific microbial metabolic functions, particularly L-arginine and uridine 5'-monophosphate (UMP) biosynthesis pathways, which interface with host inflammatory and lipid metabolism. These findings establish lentinan as a promising therapeutic candidate for metabolic syndrome management through coordinated gut microbiota-liver axis modulation, providing a conceptual framework for developing precision microbiome-targeted interventions. - Source: PubMed
Publication date: 2026/07/01
Cao DeminHuang LiweiZhang XinyueZhang XinyuZhao ZhiwenLong XidaiZhu XiaoyingLi Yulei - Accurate complete blood count (CBC) measurements are fundamental to modern hematology practice, and the introduction of new automated hematology analyzers requires rigorous analytical validation to ensure reliability, comparability, and clinical safety. The Atellica HEMA 580 (Siemens Healthineers AG, Erlangen, Germany) is a high-throughput hematology analyzer for which independent Clinical and Laboratory Standards Institute (CLSI)-guided validation data remain limited. This study aimed to perform a comprehensive analytical validation of the Atellica HEMA 580 and to evaluate its analytical comparability with the Sysmex XN-3100 (Sysmex Corporation, Kobe, Japan). Analytical validation was conducted in accordance with CLSI guidelines. Precision was assessed following CLSI EP05-A3, linearity according to EP06-A, carryover using EP07-A2, and method comparison per EP09-A3. Precision was evaluated using 15 within-run and 15 inter-assay replicates across three quality control levels. Linearity was evaluated using proportional dilution from neat to 1:16. Forty-four paired routine clinical samples were analyzed in parallel on both analyzers using ordinary least squares, Passing-Bablok, and Deming regression, supplemented by Bland-Altman analysis. Within-run analytical imprecision was low, with coefficients of variation of 0.76% for white blood cells, 0.73% for red blood cells, 0.25% for hemoglobin, and 3.59% for platelets, together with stable inter-assay reproducibility. Linearity of red blood cell and hemoglobin measurements demonstrated high proportionality across the evaluated analytical ranges. Platelet method comparison demonstrated a modest negative proportional bias (Deming slope 0.95; 95% confidence interval, 0.91-0.99). High correlation coefficients across major hematological parameters further supported strong analytical agreement between the two analyzers. Bland-Altman analysis showed minimal systematic bias, and carryover remained low across all parameters. Atellica HEMA 580 met CLSI analytical validation criteria and demonstrated analytical agreement with the Sysmex XN platform, supporting its use in routine and high-throughput hematology laboratories. - Source: PubMed
Publication date: 2026/06/12
Al Zaabi MohamedAl Mawali AmiraAl Mamari ShaimaAl Buraiki MaryamDeepak Melwin - NRAS mutations occur in 10%-30% of cutaneous melanomas and are associated with high tumor mutational burden. Mutant NRAS signaling drives aberrant cell growth and proliferation, in part, through activation of the RAF-MEK-ERK1/2 kinase pathway; however, targeted therapies to this pathway have limited effectiveness in patients with NRAS mutant melanoma. The role of other targetable signaling pathways in NRAS mutant melanoma is poorly characterized. Here, we demonstrated that one isoform of diacylglycerol kinase, diacylglycerol kinase eta (DGKη), a lipid signaling regulator, was highly expressed in NRAS mutant melanoma patient samples. Knockdown of DGKH in NRAS mutant melanoma cell lines resulted in significant growth inhibition in vitro. Transcriptomic data indicated downregulation of the estrogen response late signature, including decreased CCND1 (cyclin D1) expression following DGKH knockdown. Cell growth inhibition and decreased cyclin D1 expression correlated to an inhibition of cell cycle after DGKH knockdown. These data suggest that DGKη mediates cell cycle progression in NRAS mutant melanoma cells and represents a potential therapeutic target for these patients. - Source: PubMed
Wilson Haley PStefanski Casey DCaksa SigneMersky Glenn LVarney Scott DHaj Jelan IErkes Dan APurwin Timothy JChua VivianAplin Andrew E - More and more people are traveling to tropical and subtropical regions, whether for business or pleasure. Therefore, sound travel medicine advice is an essential part of preventive healthcare. This advice includes vaccination recommendations, malaria prophylaxis, individual risk assessment, education, and up-to-date interdisciplinary knowledge. This knowledge is especially important for vulnerable groups, such as pregnant women, children, and people with chronic illnesses. - Source: PubMed
Publication date: 2026/04/20
Frühwein MarkusSchelling JörgWendt Sebastian