Ask about this productRelated genes to: PRDX5 antibody
- Gene:
- PRDX5 NIH gene
- Name:
- peroxiredoxin 5
- Previous symbol:
- -
- Synonyms:
- ACR1, AOEB166, MGC142285, PRXV, PMP20, B166, PRDX6, PLP, SBBI10, MGC117264, MGC142283
- Chromosome:
- 11q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-07-31
- Date modifiied:
- 2016-10-05
Related products to: PRDX5 antibody
Related articles to: PRDX5 antibody
- To investigate the impact of mouth breathing (MB) on the salivary microbiome in children by comparing the differences in biochemical indicators, immune proteins and microbial community structure between mouth-breathing children and nose-breathing children, as well as among mouth-breathing children with different malocclusion types. - Source: PubMed
Publication date: 2026/05/01
Zhang JingjingWang XiaoqinWang WenxuanCao YichangWang Guiqin - Rising seawater temperatures fundamentally reshape marine ecosystems, with the Southern Ocean exhibiting vulnerability to climatic perturbations. Antarctic teleosts have evolved under near-constant sub-zero conditions, developing unique physiological adaptations. In this study, responses of Trematomus bernacchii, an endemic Antarctic fish, to three successive marine heatwave-like events were addressed. Using implantable bio-loggers, core body temperature and heart rate were monitored over 15 days, revealing a statistically significant positive correlation between core body temperature and cardiac performance, with an approximately 25% increase per °C. Molecular analyses of cardiac tissue revealed a sequential antioxidant response. An early upregulation of gpx4 suggests immediate mitochondrial protection against lipid peroxidation, while the subsequent induction of gpx1, prdx3, and prdx5 indicates a broader cytosolic defence. Furthermore, the marked decoupling between elevated gpx1 transcript levels and diminished Selenium-dependent glutathione peroxidase activity highlights a hitherto unrecognised post-transcriptional regulatory mechanism under acute thermal stress. Our findings suggest that T. bernacchii activates a sequential, organ-specific stress response to short-term warming, which may allow it to overcome episodic heatwaves. - Source: PubMed
Publication date: 2026/03/18
Piva ElisabettaPacchini SaraKholdihaghighi ShaghayeghStoilova VelizaraDrago LauraBaroni FabioFogliano ChiaraIrato PaolaSchumann SophiaSantovito Gianfranco - Porcine reproductive and respiratory syndrome virus (PRRSV), a globally significant arterivirus, is known to cause respiratory disease accompanied by redox imbalance. In this study, we observed an increase in peroxiredoxin 5 (PRDX5), the only atypical 2-Cys PRDX with multifunctional properties, following PRRSV infection. Among PRRSV-encoded proteins, nonstructural protein 4 was identified as the most potent inducer of PRDX5 expression. Further investigation revealed that reactive oxygen species (ROS) induced by PRRSV infection or nsp4 overexpression were responsible for this upregulation of PRDX5, representing a host defense mechanism to mitigate excessive ROS production. Interestingly, PRDX5 upregulation was shown to inhibit lipid synthesis through the inactivation of the AMPK-ACC1 pathway, a key regulator of fatty acid biosynthesis, which occurred independently of PRDX5's peroxidase activity. Importantly, PRDX5 significantly suppressed PRRSV proliferation, and the exogenous addition of lipids restored viral multiplication, suggesting that PRDX5 exerts its antiviral effects by disrupting lipid production. Mechanistically, PRDX5 inhibited PRRSV infection by antagonizing viral release stage. These findings highlight PRDX5 as a critical host factor that counteracts PRRSV infection, providing new insights into antiviral strategies from a redox perspective. - Source: PubMed
Publication date: 2026/03/14
Zhou YanrongXiong YujianPeng JianmingChen MenghanHuang HuiqingLi ChenyuFang LiurongXiao Shaobo - Oxidative stress (OS) plays a critical role in the pathogenesis of Alzheimer's disease (AD), yet its genetic and epigenetic regulatory mechanisms remain unclear. In this study, we applied a three-step summary-based Mendelian randomization (SMR) framework to integrate Alzheimer's disease (AD) GWAS summary statistics with peripheral-blood eQTL and mQTL datasets, and further evaluated brain-tissue relevance using GTEx v8 and AMP-AD resources. Across the three-step SMR analyses, we prioritized multiple OS-related candidate genes (e.g., CRLS1, PRKAA1, CYP2E1, GPX1, and APP) associated with AD risk, and brain-tissue analyses further highlighted KEAP1, SIRT1, and PRDX5 as region-relevant signals. Functional enrichment analyses highlighted critical pathways such as "Nrf2-mediated antioxidant response" and "PI3K-AKT signaling," emphasizing the roles of oxidative stress, mitochondrial function, and neuroinflammation in AD. Novel regulatory mechanisms were uncovered at methylation sites (e.g., cg20211653 associated with ABCA1), linking epigenetic regulation to transcriptional mechanisms and providing candidates for brain-tissue follow-up. This study provides new insights into the molecular underpinnings of AD, bridging genetic variation, epigenetic regulation, and transcription, and identifies potential therapeutic targets for mitigating oxidative damage and neurodegeneration. - Source: PubMed
Publication date: 2026/03/17
Wu LiuDong Yu-TingMu XinLuo XiaoChen Ze-Jun - Over the past few decades, the climate has undergone significant transformations, with increasing temperatures emerging as one of the most critical threats to marine ecosystems. Mounting evidence of marine heatwaves (MHWs) events in the Southern Ocean and Antarctic region has intensified scientific efforts, revealing that these fragile ecosystems may act as crucial early indicators of wider climate-driven changes in marine environments' biodiversity. This study explores the transcriptional responses of Trematomus bernacchii to thermal stress, focusing on the liver and spleen, key organs in immune defence and metabolic regulation. Adult specimens (total n = 30) were collected from Terra Nova Bay (Ross Sea) during the austral summer (late October 2022) and exposed to a temperature gradient, mimicking MHWs, ranging from 0 °C to +3 °C; a separate control group was maintained at 0 °C. Expression levels of antioxidant-related genes (prdx3, prdx5, cat, sod1, sod2, gpx1, gpx3, gpx4) along with two innate immunity genes (tlr2 and tlr9) were analysed in liver and spleen tissues from five biological replicates. The liver showed an early and dynamic response: gpxs, sod2, Prdxs, and tlrs were upregulated at +1 °C and +2 °C but downregulated at +3 °C, suggesting early mitochondrial antioxidant response and immune activation. In contrast, the spleen remained largely unresponsive at mild stress levels, with marked activation of gpx1, sods, Prdxs, and tlrs only at +3 °C. Cat remained unresponsive to thermal stress. These results indicate a delayed but coordinated response, suggesting an energy-conservation mechanism under increasing thermal stress. They underscore the limited plasticity of polar fish physiology and offer molecular insights into the vulnerability of Antarctic marine species in a warming climate. - Source: PubMed
Publication date: 2026/03/10
Piva ElisabettaKholdihaghighi ShaghayeghAmetrano AlessiaSchumann SophiaPacchini SaraCortese MartinaDrago LauraBaroni FabioFogliano ChiaraCoscia Maria RosariaIrato PaolaSantovito Gianfranco