Ask about this productRelated genes to: ERAS antibody
- Gene:
- ERAS NIH gene
- Name:
- ES cell expressed Ras
- Previous symbol:
- HRAS2, HRASP
- Synonyms:
- -
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-08-25
Related products to: ERAS antibody
Related articles to: ERAS antibody
- Recovery after total knee arthroplasty (TKA) remains heterogeneous despite mature surgical techniques and standardized enhanced recovery after surgery (ERAS) pathways. Perioperative inflammation offers an unusually actionable basis for stratification because it can be measured before surgery, tracked during recovery, linked to pain, swelling, and quadriceps dysfunction, and modified by available interventions. We advance a three-axis inflammatory phenotype comprising preoperative inflammatory tone, acute response magnitude, and resolution kinetics. Preoperative systemic immune-inflammation index (SII), conventionally calculated from a CBC obtained at a prespecified time point, can contribute to Axis 1, and serial SII may be evaluated as a candidate trajectory; the modified frailty index (mFI) summarizes preoperative deficit burden. The framework tests whether their information is complemented by the joint temporal response to surgical perturbation and the coordination of systemic, local, and functional recovery. The three axes are primarily continuous dimensions; any latent classes are exploratory and require reproducibility across sites. Serial interleukin-6, C-reactive protein, fibrinogen, cytokine-panel, swelling, and temperature studies support these complementary dimensions. Prognostic cohorts connect inflammatory profiles with pain, function, complications, and recovery trajectories, while randomized trials demonstrate that the acute response can be pharmacologically shifted. The framework integrates accessible C-reactive protein and complete blood count-derived ratios with targeted cytokines and local swelling or temperature. Each signal is paired with mechanism-aligned outcomes such as voluntary activation, quadriceps strength, Timed Up and Go performance, and Knee injury and Osteoarthritis Outcome Score domains. The model organizes prospective, safety-gated tests of phenotype-adapted ERAS and rehabilitation, including protocol- or trial-based anti-inflammatory strategies, compression, neuromuscular electrical stimulation, nutritional support, progressive resistance training, and extended supervised rehabilitation. Five prospective predictions link each phenotype axis to a distinct recovery mechanism and intervention response. Multicenter trajectory cohorts can derive and validate the phenotype, followed by biomarker-stratified factorial trials powered for treatment-by-phenotype interaction. This framework converts perioperative inflammation from an isolated laboratory signal into a dynamic recovery phenotype and proposes a testable blueprint for prospective evaluation of adaptive ERAS and precision rehabilitation after TKA. Incremental utility relative to existing indices remains a prospective hypothesis. - Source: PubMed
Publication date: 2026/09/11
Chen XuLuo XiaolingQiu YaxiZhou QinZhong ShangjieZhu HongyanYao MeiLi Peifang - While non-specific pleural empyema in children can be successfully managed with conservative drainage and thoracentesis in 80-84% of cases, tuberculous pleural empyema (TB empyema) exhibits high resistance and frequently requires extensive thoracic surgery. The choice of surgical scope depends directly on disease stage and secondary complications. - Source: PubMed
Publication date: 2026/09/02
Giller Dmitry BChuishchev Alexandr DEnilenis Inga IKoroev Vadim VKesaev Oleg SShcherbakova Galina VGadzhieva Patimat GSeverova Ludmila PKlevno Nadezhda IKazakov Alexey VFrolova Olga PButylchenko Olga VIlyukhin Alexandr NBasangova Valeriya AMorozova Evelina YMartel Ivan I - Respiratory tract infections (RTIs) caused by viruses are a public health problem, contributing to hospital admissions and morbidity worldwide. The COVID-19 pandemic substantially altered the detection patterns of respiratory viruses through public health interventions. Longitudinal data on these changes and viral seasonality remain limited in Saudi Arabia. This eight-year study evaluated epidemiological and seasonal patterns of major respiratory viruses across the COVID-19 era at a major Saudi tertiary care center. - Source: PubMed
Publication date: 2026/08/31
Alzamil LamaBagasi ArwaAlkudmani Zeina SAlmatrudi Hamad MAlrezaihi Abdulrahman FAlmuqrin Abdulaziz M - : Postoperative pain after major cancer surgery contributes to pulmonary, cardiovascular, metabolic, and functional complications. Thoracic epidural analgesia [TEA] has traditionally been considered the standard analgesic technique for open thoracic and upper abdominal oncologic surgery, although minimally invasive techniques and ERAS pathways have prompted a re-evaluation of its role. : This narrative review summarizes evidence from PubMed and MEDLINE published between 1995 and June 2026, emphasizing randomized trials, systematic reviews, meta-analyses, large observational studies, and selected work by the authors. : TEA provides superior dynamic analgesia and reduces opioid consumption, facilitating early mobilization, respiratory recovery, and gastrointestinal function. By attenuating sympathetic and neuroendocrine stress responses, it may contribute to reductions in pulmonary complications, ileus, insulin resistance, and delirium, particularly in elderly, frail, sarcopenic, and high-risk patients. Limitations include hypotension, urinary retention, technical failure, and rare but potentially serious complications such as epidural hematoma. In minimally invasive surgery, alternative regional techniques and multimodal opioid-sparing analgesia often achieve comparable postoperative outcomes with fewer hemodynamic effects, supporting selective rather than routine TEA use. Although neuraxial techniques may have immunomodulatory effects and potentially preserve immune function, randomized studies have not demonstrated a reduction in cancer recurrence or an improvement in long-term survival. : TEA remains an effective analgesic strategy for selected patients undergoing major open thoracic and upper abdominal cancer surgery. In contemporary perioperative practice, its use should be individualized according to surgical invasiveness, patient characteristics and expected postoperative pain. Current evidence supports TEA primarily as a perioperative analgesic and recovery strategy, with no established oncologic benefit. - Source: PubMed
Publication date: 2026/08/26
Motamed CyrusCaballero Marie Josée - Colorectal cancer (CRC) remains one of the most frequently diagnosed malignancies worldwide and a leading indication for major abdominal surgery, with a rising incidence among younger adults. Because CRC resection is a physiologically demanding procedure performed in a frequently comorbid, often anemic and malnourished population, the preoperative period represents a decisive window in which laboratory and diagnostic testing shapes staging, risk stratification, and optimization. This narrative review is deliberately confined to the preoperative window-from histological diagnosis to the day of elective, curative-intent colon or rectal resection-and synthesizes evidence retrieved from PubMed/MEDLINE, Scopus, and ScienceDirect together with current society guidelines. It is organized around four themes: (i) the core laboratory workup, including the complete blood count and preoperative anemia, iron studies, metabolic and hepatic panels, coagulation testing, and carcinoembryonic antigen (CEA); (ii) the diagnostic and staging workup, encompassing complete colonic evaluation, contrast-enhanced computed tomography, pelvic magnetic resonance imaging for rectal cancer, and the selective role of positron emission tomography; (iii) risk stratification and preoperative optimization, spanning patient blood management, nutritional assessment and albumin, computed-tomography-defined low skeletal muscle mass, frailty, functional capacity, prehabilitation, and glycemic control; and (iv) molecular characterization, distinguishing mismatch-repair/microsatellite-instability (MMR/MSI) testing-an established, widely recommended component of CRC evaluation-from genuinely emerging biomarkers such as circulating tumor DNA (ctDNA) and systemic inflammatory and prognostic nutritional indices. Differences between colon and rectal cancer, elective and emergency presentation, and upfront versus post-neoadjuvant surgery are signposted throughout. We further integrate these elements within contemporary guideline and Enhanced Recovery After Surgery (ERAS) frameworks, including the 2025 ERAS Society recommendations for elective colorectal surgery, and distill them into a practical, evidence-based preoperative checklist specifying thresholds, timing, interventions, and strength of supporting evidence. We emphasize that the prognostic power of postoperative ctDNA does not yet translate into ctDNA-guided treatment decisions outside clinical trials. The central message is that preoperative testing in CRC should be purposeful and stage- and risk-adapted rather than reflexive: each investigation should refine staging, modify perioperative management, or enable measurable optimization. Each risk domain is paired with the intervention it should trigger, the criteria identifying candidates for extended thromboprophylaxis are specified, and the systemic inflammatory indices are framed as a trigger for optimization rather than as prognostic commentary. - Source: PubMed
Publication date: 2026/09/11
Tsokkou SophiaChatzikomnitsa ParaskeviPapakonstantinou MenelaosGkaitatzi Areti DanaiLiampou EftychiaKolympa GeorgiaFantakis AntoniosToutziari EvdokiaGiakoustidis DimitriosPapamitsou TheodoraPapadopoulos Vasileios NGiakoustidis Alexandros