Ask about this productRelated genes to: EXT1 antibody
- Gene:
- EXT1 NIH gene
- Name:
- exostosin glycosyltransferase 1
- Previous symbol:
- LGCR, LGS
- Synonyms:
- ttv
- Chromosome:
- 8q24.11
- Locus Type:
- gene with protein product
- Date approved:
- 1993-05-04
- Date modifiied:
- 2019-04-23
Related products to: EXT1 antibody
Related articles to: EXT1 antibody
- Delivering landscape-scale nature recovery depends on the effective acquisition and development of skills across agricultural, environmental, and governance contexts. This study draws on 25 semi-structured interviews with farmers, land managers, and intermediary organisations (delivery partners, bridging organisations, extension/advisory services) across England to examine how skills are acquired and developed in practice. Informed by taskscapes literature and structured around a novel five-domain analytical framework-systems thinking, lifelong and life-wide learning, collaborative partnerships, agri-environmental entrepreneurship, and technical expertise-findings highlight the centrality of collaborative, entrepreneurial, and technical capacities. They also reveal core tensions and misalignments: between (1) policy ambition and institutional capacity; (2) fragmentation of learning pathways caught between standardisation and flexibility; and (3) entrepreneurial initiative within compliance-oriented governance structures. The research underscores the need for tailored skill frameworks spanning formal, informal, and non-formal learning pathways to support adaptive knowledge exchange and the practical delivery of landscape-scale nature recovery. - Source: PubMed
Publication date: 2026/04/26
Davis Joshua - Acute respiratory distress syndrome (ARDS) has a high clinical mortality rate and continues to draw research attention regarding its mechanisms and potential treatments. Disruption of the endothelial barrier is a primary pathological feature, and glycocalyx degradation is a key factor contributing to this disruption. Human umbilical cord mesenchymal stem cells (hucMSCs) exhibit strong anti-inflammatory and immunomodulatory effects, making their application in ARDS treatment an area of increasing interest. Proteomic screening identified Cxcl12 as a protein secreted by hucMSCs. In male C57 mice and cell models, lipopolysaccharide (LPS) was used to induce injury, followed by interventions with hucMSCs or hucMSCs with silenced Cxcl12 to assess glycocalyx-related proteins SDC-1, HS, and the repair marker EXT-1. To evaluate downstream signaling, the CXCR4 receptor was inhibited and related indicators were examined. Silencing Cxcl12 reduced the therapeutic effect of hucMSCs on LPS-induced glycocalyx damage. Inhibition of CXCR4 also weakened the effect of Cxcl12. These findings indicate that hucMSCs alleviate LPS-induced glycocalyx damage in pulmonary vascular endothelial cells by secreting Cxcl12, which activates the downstream receptor CXCR4, providing a therapeutic effect for ARDS. - Source: PubMed
Publication date: 2026/04/16
Cui JinfengPeng ZhenyiChen YuanyuanLiu WeiChen QiuwenWang XiaozhiWang TaoHuang XiaoSun Ting - Spinal osteochondromas develop from aberrant endochondral ossification of the vertebrae, which originate from the sclerotome of the paraxial mesoderm. These tumors typically involve the posterior elements, such as the spinous process, lamina, or pedicles. Spinal osteochondromas are rare, constituting less than 2% of all osteochondromas and under 4% of spinal tumors. - Source: PubMed
Publication date: 2026/03/02
Aljesri Muhammad AbdalrahmanIssa MohamedIssa Nourelhuda - Chronic Kidney Disease (CKD) has emerged as a significant global public health concern, with membranous Nephropathy (MN) being the most prevalent pathological type of nephrotic syndrome in adults. MN is classified as an antibody-mediated autoimmune disease. There is a growing interest in the research of MN-related antigens. Furthermore, the treatment of MN predominantly relies on the administration of immunosuppressants, with traditional regimens such as corticosteroids and cyclophosphamide, which have significant side effects, and rituximab, having a 35-40% failure rate, highlighting the critical need for the development of specific and effective immunotherapy strategies. In this review, we summarized the research progress on newly discovered MN-related antigens, including exostosin 1/exostosin 2(EXT1/EXT2), Neural Cell Adhesion Molecule 1 (NCAM-1), Neural Epidermal Growth Factor-like 1 (NELL-1), Contactin 1 (CNTN1), Semaphorin 3B, High-Temperature Recombinant Protein A1 (HTRA1), protocadherin FAT atypical cadherin 1(FAT1) and Protocadherin 7(PCDH7). Among them, NELL-1 and HTRA1 primarily serve as target antigens for primary MN, and their serum antibody titers show a strong correlation with disease activity. While EXT1/EXT2, NCAM1, CNTN-1, and FAT1 mainly act as target antigens for secondary MN. In addition, we evaluated the clinical applications and efficacy of novel immunosuppressants and therapeutic approaches, including new anti-CD20 antibodies, proteasome inhibitors, anti-plasma cell therapies, belimumab, complement inhibitors, and immunoadsorption. The new anti-CD20 agents represented by obalimumab and obinutuzumab, along with anti-plasma cell therapies such as daratumumab, have emerged as ideal alternatives for patients with rituximab resistance. Other therapeutic approaches, including complement inhibitors, immunoadsorption, and belimumab, have also exhibited their unique advantages. - Source: PubMed
Publication date: 2026/03/31
Sui LuJin ZihangMeng YilinWu HaozeChe LigeerSun Li - To explore the genetic etiology of 46 Chinese pedigrees affected with Hereditary multiple exostoses (HME) and provide genetic counseling and reproductive intervention. - Source: PubMed
Su LilanHu XiaoDai JingWan ZhengxingYi DuoLi ShuangfeiHu LiangTan YueqiuGong FeiLin GeLu GuangxiuZhang QianjunDu JuanHe Wenbin