Ask about this productRelated genes to: GSPT2 antibody
- Gene:
- GSPT2 NIH gene
- Name:
- G1 to S phase transition 2
- Previous symbol:
- -
- Synonyms:
- eRF3b, FLJ10441
- Chromosome:
- Xp11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-05
- Date modifiied:
- 2015-09-10
Related products to: GSPT2 antibody
Related articles to: GSPT2 antibody
- Approximately 6% of individuals with neurodevelopmental disorders are predicted to be X-linked, and the GSPT2 gene, located at Xp11.22, has not yet been associated with any Mendelian disease. - Source: PubMed
Publication date: 2025/12/17
Wei YudaLiu KaiMi ChangruiYu JingSun RuopengMiao ShengxingLi HaiqiXue HuiliLiu XiaxiaHu YanyanQi YongzhenZhang JieTong LiliZhao ChenJiang LiangqianTeng JuanGeng XingzhuGai ChengchengXu HongyanLi LinChe FengyuanGao ChunhaiZhao Xiangyu - Endometrial cancer (EC) is a prevalent gynecological malignancy that imposes significant health and economic burden on women worldwide. The aim of this study was to investigate the expression levels of G1 to S phase transition 2 (GSPT2) and cold-inducible RNA-binding protein (CIRBP) in endometrial cancer tissues relative to normal endometrial tissues and to evaluate their potential as biomarkers for diagnosis and prognosis. We conducted a prospective analysis involving RNA extraction, real-time polymerase chain reaction (RT-PCR), and immunohistochemistry (IHC) to assess gene expression and protein localization. Our findings revealed that GSPT2 was significantly overexpressed (t = 2.754, P = .008611), whereas CIRBP was underexpressed (t = 3.344, P = .001647) in EC tissues. Survival analysis demonstrated that high GSPT2 expression correlated with poor overall survival (OS) (P < .0001), in contrast to high CIRBP expression, which was associated with improved OS (P < .0001). Additionally, GSPT2 expression was positively correlated with aggressive pathological features, including higher tumor grading and International Federation of Gynecology and Obstetrics (FIGO) staging, Lymphovascular Space Invasion (LVSI) (P < .05), while CIRBP showed negative correlations with these characteristics (P < .05). These results underscored that high GSPT2 expression should be closely associated with EC progression and poor prognostic, while CIRBP exert a protective effect. The potential of GSPT2 as a poor prognostic marker and CIRBP as a favorable prognostic marker suggest their utility in guiding treatment decisions. Despite limitations such as a relatively small sample size and the lack of functional experiments, our study highlights GSPT2 and CIRBP as promising biomarkers for early diagnosis and targeted therapy in endometrial cancer. Future research should focus on larger cohorts and functional validations to further elucidate the roles of these biomarkers in clinical practice and personalized medicine approaches. - Source: PubMed
Cai YuWang MingHe YueWu Yu-MeiWang JiaoXing LiHan QiHe Yuan-Hui - Targeting undruggable proteins by inducing proximity between E3 ligase and their substrates has emerged as an innovative strategy for tackling challenging diseases. In this study, we identified a novel GSPT1 degrader, 4a (KMG-1068), through screening of our in-house small molecule library. Treatment with 4a demonstrated significant anti-proliferative activity across multiple cell lines, which was diminished by co-treatment with MLN4924, suggesting the involvement of the Cullin-containing complex. Quantitative proteomic analysis indicated that 4a predominantly induces the degradation of GSPT1/2. We further validated that 4a-mediated GSPT1/2 degradation is dependent on both CUL4 and CRBN. Moreover, 4a forms a ternary complex with CRBN and GSPT1/2, albeit with weaker binding affinity compared to reported GSPT1 molecular glues. BRET assays and competition assays with pomalidomide demonstrated that 4a binds to the C-terminal IMiD binding site of CRBN, leading to the degradation of GSPT1. Despite lacking the characteristic glutarimide moiety present in other CRBN-based molecular glue degraders, 4a interacts effectively with the IMiD binding site of CRBN. Structural characterization through analog synthesis further underscored the importance of specific structural features for CRBN engagement, GSPT1/2 degradation, and anti-proliferative effects, establishing 4a as a promising novel GSPT1/2 degrader with significant therapeutic potential. - Source: PubMed
Publication date: 2025/04/15
Park SeulkiTakwale Akshay DLee Ji-EunYu NamsikKim Yong HyoLee Joo YounCho Yong HeeCho Jin HwaMoon Jeong HeeLee GaseulKim Jung-AeHwang Jong YeonKim Jeong-Hoon - Nuptial pads, a typical sexually dimorphic trait in anurans, are located on the first digit of the male forelimb in Rana chensinensis and exhibit morphological changes synchronized with breeding cycles. However, the genetic mechanisms underlying its formation and seasonal changes remain poorly understood. - Source: PubMed
Publication date: 2024/12/30
Qiu FuyuanAi QingboLi JunWu Hua - Eukaryotic elongation factor 1 alpha 2 (eEF1A2) is a protein coding gene which is involved in tumor development and progression in several types of human cancer, but little is known about the function of eEF1A2 proteins in gastric cancer (GC). This study aimed to investigate the effects of , and on the migration of GC cells. - Source: PubMed
Publication date: 2024/09/27
Ma HaixiuSuo LinaZhao JingMa RonghuaWang QiLiu JunQiao JinwanWu JuanAn JuanLiu YanXing YonghuaWang HaiyanSu Zhanhai