Ask about this productRelated genes to: MCM10 antibody
- Gene:
- MCM10 NIH gene
- Name:
- minichromosome maintenance 10 replication initiation factor
- Previous symbol:
- -
- Synonyms:
- PRO2249, CNA43, DNA43
- Chromosome:
- 10p13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-22
- Date modifiied:
- 2015-08-25
Related products to: MCM10 antibody
Related articles to: MCM10 antibody
- - Source: PubMed
Publication date: 2026/04/11
Tian QiusiBao ZhijunZhao YifeiZhang Qun - To investigate the expression and predictive value of minichromosome maintenance proteins MCM2, MCM4, and MCM10 in hepatocellular carcinoma (HCC) for postoperative recurrence, and to develop an integrated predictive model. - Source: PubMed
Publication date: 2026/03/21
He BinTang Ke - Gastric cancer (GC) remains a major global health challenge, with chemotherapy resistance significantly hindering treatment efficacy. A significant proportion of chemotherapeutics impact DNA replication, yet the mechanisms by which tumors evade this lethality remain incompletely understood. Notably, minichromosome maintenance 10 replication initiation factor (MCM10) is pivotal in initiating DNA replication, holding promise in mediating acquired chemotherapy resistance. This work aims to elucidate the driving roles of MCM10 GC pathogenesis and chemotherapeutic resistance. - Source: PubMed
Publication date: 2026/02/27
Xie FudaLeung Hoi WingLyu YangYu PeiyaoFeng TiejunChen BonanWu JialinTham JensonFang CanbinCheung Alvin H KChow ChitJiang JianhuiHu JintaoZhang FengbinZhu ChaoweiZhong KeliSun MeihengZhang GeYu SifanXu DazhiWang ShouyuHuang BingZhuang KangminLuo XiaobeiLi AiminGuo QingGao ChanchanZhang BinMa YuanWu William KkAn LiweiWong Chi ChunYu JunTo Ka FaiKang Wei - This study was conducted to elucidate the molecular and metabolic differences in ileal development according to birth weight in neonatal piglets. A total of 126 neonatal piglets born from Yorkshire × Landrace × Duroc crossbred sows were used, and the top 5% (H group, 1.77 ± 0.02 kg) and bottom 5% (L group, 0.72 ± 0.03 kg) of birth weights were selected for analysis. Ileal tissues were collected for transcriptomic (RNA-seq) and targeted metabolomic (GC-MS) analyses, and selected genes were validated using RT-qPCR. A total of 112 differentially expressed genes (DEGs) were identified, among which RFC3, PCNA, MCM3, MCM10, AURKA, AURKB, CCNB2, CCNA2, CCNF, and SI were significantly upregulated in the H group ( < 0.05). These genes were mainly involved in pathways related to DNA replication, cell division, and nutrient digestion and absorption. In addition, metabolomic analysis revealed that pyruvic acid concentrations were significantly higher in the H group ( < 0.05), indicating the activation of energy metabolic pathways. These results indicate that high-birth-weight piglets possess a genetic foundation for enhanced cellular proliferation and energy metabolism, and they further highlight potential molecular targets for improving growth performance and intestinal development in low-birth-weight piglets. - Source: PubMed
Publication date: 2026/01/11
Lee HyunseoKim GyuseongChoi WonvinKim Minju - Colorectal cancer (CRC) remains the second leading cause of cancer mortality in the U.S., with significant racial and ethnic disparities in incidence, survival, and mortality rates. The rising incidence of early-onset CRC and the frequent presentation at advanced stages of CRC among the Hispanics makes this an important ethnic group to study. A deeper understanding of the complex interplay between molecular, genetic, and environmental factors is critical for developing targeted therapies to reduce the prevalence in specific racial and ethnic groups, such as Hispanics. This study explores the role of stress-survival pathway (SSP) genes in early-onset and late-stage CRC, primarily focusing on disparities between Hispanics and Non-Hispanic Whites (NHWs). Additionally, this study investigates the role of MCM10, in contributing to CRC disparities among the Hispanic populations with an emphasis of early-onset and late-stage CRC Hispanics. - Source: PubMed
Publication date: 2026/01/07
Islam Khan Md ZahirulBasnet UrbashiNair SoumyaKulkarni AditiRangel Frances ATorres AngelBasu AnamikaAlmeida Igor CAl-Hilal TaslimRoy Sourav