Ask about this productRelated genes to: SMC4 antibody
- Gene:
- SMC4 NIH gene
- Name:
- structural maintenance of chromosomes 4
- Previous symbol:
- SMC4L1
- Synonyms:
- hCAP-C, CAP-C
- Chromosome:
- 3q25.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-22
- Date modifiied:
- 2016-10-05
Related products to: SMC4 antibody
Related articles to: SMC4 antibody
- E2F7 regulates cell cycle progression and is overexpressed in multiple cancers, but its role in tumor, which macrophage crosstalk in colorectal cancer (CRC) remains unclear. - Source: PubMed
Publication date: 2026/05/12
Gao ShengZuo KaiFeng LeyiCao HaileiJiao XuepingMa ChenhuiZhang QuanmaoLi Jia - Maize (Zea mays L.) is a major cereal crop of global importance, valued not only for its nutritional importance but also for its diverse phytochemical composition. Metabolomics offers a comprehensive platform to investigate physiological and biochemical alterations caused by various factors and facilitates the analysis of metabolic alterations associated with varying temperature tolerance in maize genotypes. - Source: PubMed
Publication date: 2026/04/30
Ramazan SalikaBeniwal RahulDar Zahoor AShah Manzoor A - Dosage compensation (DC) in Caenorhabditis elegans utilizes a condensin complex that resembles mitotic condensins but differs by 1 subunit, DPY-27. DPY-27 replaces SMC-4, one of the structural maintenance of chromosome (SMC) proteins that is responsible for hydrolyzing ATP, required for the condensation of DNA and other mitotic condensin functions. To understand whether the ATPase function is required in DC, we first demonstrated that DPY-27 is capable of hydrolyzing ATP in vitro. Then, we used CRISPR/Cas9-mediated genome editing to generate an ATPase mutation in dpy-27. Although the mutant protein is expressed and is incorporated into the condensin IDC complex, this mutation results in a loss of DC. Specifically, we found that without ATPase function, DPY-27-containing condensin IDC has reduced capacity to bind DNA, condense the X chromosomes, and facilitate H4K20me1 enrichment on the X-chromosomes. Our results suggest that condensin IDC, like mitotic condensins, uses ATP hydrolysis to perform its functions, making C. elegans DC a model for how activities attributed to mitotic condensins can be used to regulate gene expression. - Source: PubMed
Chawla BahaarJatia SuchiSloan DillonEduful JoshuaMendoza HectorMcClear Christian ATran JeannineCsankovszki Gyorgyi - Cervical cancer remains a significant global health burden, with the molecular determinants of its progression and therapeutic resistance not fully elucidated. This study aimed to identify DNA damage-related genes with prognostic and functional significance. - Source: PubMed
Publication date: 2026/03/09
Wu HaixiaYu YilinWang WeiXu Qin - Multiple myeloma (MM) is a complex hematological malignancy characterized by the uncontrolled proliferation of plasma cells in the bone marrow. Emerging evidence suggests that the aberrant activation of specific gene regulatory elements known as SE plays a crucial role in driving oncogenic gene expression programs in cancer. In this study, we investigated the role of the SE-driven SMC4 in promoting myeloma growth. Depletion of SMC4 resulted in a significant impairment of myeloma cell proliferation and clonogenicity. Mechanistically, we identified that SMC4 orchestrates the epigenetic modulation of the IFI16-dependent STING signaling pathway. This epigenetic enhancement of the IFI16-STING axis led to increased production of pro-inflammatory cytokines, creating a favorable microenvironment for myeloma cell growth. Furthermore, we established a direct link between the SE-driven SMC4 and the upregulation of IFI16 and STING gene expression in MM cells. Importantly, pharmacological inhibition of the IFI16-STING pathway abrogated the oncogenic effects mediated by SMC4. Our findings uncover a novel regulatory circuit involving SMC4 and the IFI16-STING signaling axis that promotes myeloma growth. Targeting this epigenetic network may hold therapeutic potential to intervene in myeloma progression and improve patient outcomes. - Source: PubMed
Publication date: 2026/03/07
Guan JiayunLin XuanyiDai ZhenfengZhou JianbiaoCai ZhenTan Tze KingChung Tae-HoonZhang XiaochenChng Wee-JooRong XiaoxiangJia Yunlu