Ask about this productRelated genes to: ZG16 antibody
- Gene:
- ZG16 NIH gene
- Name:
- zymogen granule protein 16
- Previous symbol:
- JCLN
- Synonyms:
- hZG16, JCLN1, ZG16A
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-01-05
- Date modifiied:
- 2015-01-12
Related products to: ZG16 antibody
Related articles to: ZG16 antibody
- Hepatocellular carcinoma (HCC) is a highly aggressive primary liver malignancy characterized by limited therapeutic options and poor prognosis. Within the tumor microenvironment (TME), tumor-associated macrophages (TAMs) predominantly exhibit an M2-like phenotype, contributing to immune escape and tumor progression. Zymogen granule protein 16 (ZG16) has been reported to be downregulated in HCC, but its precise biological function and molecular mechanisms remain poorly understood. Therefore, we aimed to investigate the impact of ZG16 on HCC cell metastasis and TAM infiltration, as well as to elucidate its molecular mechanism. - Source: PubMed
Publication date: 2026/03/04
Meng HuiWang ZeyuanWang LiyeFang XiaokunLi HaonanMa WeiqianDing YiNan ManmanMeng YuLi LingLi YizhenChen KuishengZhang Mingzhi - Among individuals with a history of smoking but preserved spirometry (tobacco exposed with preserved spirometry, or TEPS), lung volume-based stratification identifies two phenotypes at increased risk for COPD (pre-COPD): those with a relatively elevated total lung capacity ([TLC]high) and those with a relatively elevated functional residual capacity-to-TLC ratio ([FRC/TLC]high). These subgroups exhibit distinct respiratory symptoms, radiographic abnormalities, and clinical trajectories. - Source: PubMed
Publication date: 2026/03/03
Zeng SiyangGuo ClairePratte Katherine ALuo GangBowler Russell PArjomandi Mehrdad - Lynch syndrome, historically known as hereditary nonpolyposis colorectal cancer, is caused by germline mutations in the DNA mismatch repair (MMR) genes, , and . While the genetic changes associated with Lynch Syndrome have previously been characterized, there have not been studies of the associated proteomic alterations, in part because of the limited availability of primary samples and the absence of model systems. In this study, the first large-scale tissue proteomic assessment of Lynch Syndrome samples as well as three other subtypes of colorectal cancer was completed with specimens from the Ohio Colorectal Cancer Prevention Initiative. The cohort contained three groups of microsatellite unstable (MSI-high) CRC patients (Lynch syndrome, double somatic MMR mutation, and MLH1 hypermethylation) and a group of microsatellite stable (MSS) CRC patients. A total of 122 tumor and complimentary normal mucosa samples from 61 patients were evaluated using label-free bottom-up proteomic analysis. Hierarchical clustering analysis of the global proteome showed that the MSS group was significantly different than the three MSI-high groups. Of the 1,084 proteins found to be dysregulated across all four colorectal cancer subtypes, there were age at diagnosis associated shifts in proteins correlated with tumor proliferation and immune regulation for the Lynch syndrome and Double Somatic samples. The proteins TPD52, GMDS, and DSP showed increased protein abundance correlated with older age at diagnosis. In addition, the Lynch syndrome samples showed substantial sex-based differences in immune and inflammatory pathways, for example, downregulation of ZG16, DIS3, and WDR43. This study fills a critical gap as the first proteomic characterization of Lynch syndrome samples to date. Data are available via ProteomeXchange with identifier PXD073693. - Source: PubMed
Publication date: 2026/01/29
Tobias FernandoSekera Emily RXiong XingzhaoFang FeiHampel HeatherPearlman RachelLiu XiaowenSun LiangliangHummon Amanda B - Berberine, a benzyl isoquinoline alkaloid, is used in food for its diverse spectrum of biological activities. Inflammatory bowel disease (IBD) is a widespread condition characterized by frequent occurrence and limited therapeutic success. Berberine has been shown to alleviate colitis through enhancement of the intestinal barrier and modulation of gut microbial balance. However, the further mutualistic balance mechanism between microbes and the mucus of berberine in alleviating IBD still needs to be clarified. Our findings demonstrated a strong association between berberine's therapeutic efficacy and alterations in the gut microbiota. This includes enhancements in the level of IgA-coated bacteria, Zg16, Reg3g, and Pla2g2a, all of which contribute to microbiota homeostasis. Moreover, the beneficial effect on gut barrier function of berberine was mostly attributed to and -associated mucin-SCFA metabolism. This study lays a critical groundwork for the development of berberine-based functional food additives that harness its nutraceutical potential. - Source: PubMed
Publication date: 2026/02/04
Chen YanliWang YanHe YanminQiao LeiDai WeilongLiu YalinLu XiaoxiGan YujieSun LuYang MingzhiWang YizhenFu JieJin Mingliang - Colorectal cancer (CRC) is the primary driver of cancer-related death and illness across the world. Despite the full-scale shift of the treatment approach for some colorectal cancer patients due to the use of immune checkpoint inhibitors (ICIs), primary resistance still poses a huge challenge to clinicians. Bile acid metabolism is involved in the pathogenesis of CRC. However, its particular function in shaping the tumor immune microenvironment (TIME) and its effect on prognosis and immune treatment response remain unclear. - Source: PubMed
Publication date: 2026/01/12
Feng LiWang MinLi XinWu LongGu DeXinZhang BinZheng PengYang QifengWang KeMao Gang