Ask about this productRelated genes to: SERPINE2 antibody
- Gene:
- SERPINE2 NIH gene
- Name:
- serpin family E member 2
- Previous symbol:
- PI7
- Synonyms:
- PN1, GDN, PNI, nexin
- Chromosome:
- 2q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-09-01
- Date modifiied:
- 2016-04-06
Related products to: SERPINE2 antibody
Related articles to: SERPINE2 antibody
- The extracellular matrix (ECM) plays a critical role in the tumor microenvironment (TME). However, the prognostic relevance of matrisome-related genes (MRGs) in bladder cancer (BLCA) remains poorly understood. This study aimed to establish a matrisome-related gene signature for prognostic stratification in bladder cancer and to further characterize its associations with tumor microenvironmental features and candidate compounds. - Source: PubMed
Publication date: 2026/04/20
Wu GongpingYu WeitaoYao DongnuanMa XuemingFan ChengweiHou JuanjuanRen XuezhaoTian Junqiang - Epithelial-mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression. To investigate KAT2A and SERPINE2 in RCC, we assessed their expression and downstream effects using real-time quantitative PCR and western blot. EMT markers (E-cadherin, N-cadherin, Vimentin) and SERPINE2 succinylation were also measured. Functional assays (CCK-8, colony formation, transwell, tube formation) evaluated cell viability, proliferation, migration, and angiogenesis. Co-localization (immunofluorescence) and interaction (co-immunoprecipitation) of KAT2A and SERPINE2 were confirmed. Finally, Ki-67, KAT2A, and SERPINE2 expression in RCC tumors were examined via immunohistochemistry. We identified that KAT2A expression was significantly elevated in RCC tissues and correlated with poor patient prognosis. Functionally, KAT2A depletion markedly inhibited RCC cell proliferation, migration, EMT, and HUVECs angiogenesis in vitro, as well as suppressed tumor growth in vivo. Mechanistically, KAT2A directly interacted with SERPINE2 and promoted its succinylation at lysine 158 (K158). This post-translational modification enhanced SERPINE2 protein stability, and SERPINE2 overexpression effectively reversed the tumor-suppressive effects induced by KAT2A silencing. Our findings reveal that the KAT2A/SERPINE2 axis is a key regulator of RCC pathogenesis, identifying KAT2A-mediated SERPINE2 succinylation as a novel mechanism and potential therapeutic target for RCC treatment. - Source: PubMed
Publication date: 2026/04/12
Liu Chang-ChengLi Xue-Dong - - Source: PubMed
Publication date: 2026/03/24
Chen Wen-JinDong Ke-QinPan Xiu-WuGan Si-ShunXu DaChen Jia-XinChen Wei-JieLi Wen-YanWang Yu-QiZhou WangRini BrianCui Xin-Gang - This study aimed to isolate different cancer cell populations and characterize their secretome profiles to better understand their functional roles in metastasis and tumor progression. For this purpose, we analyzed the secretomes of CD133 and CD326 (EpCAM) positive subpopulations derived from the A549 cell line. - Source: PubMed
Publication date: 2026/03/23
Ömerli FatihDoğan Sarıkaya MedineAcar Mustafa BurakÖzcan ServetÇokkeçeci MuratYılmaz Seçil - Hippocalcin (HPCA), a neuron-enriched calcium-binding protein, plays a critical role in brain function, but its role in neural precursor cells remains unclear. N-methyl-D-aspartate (NMDA) receptors are calcium-permeable glutamate receptors essential for neurodevelopment and synaptic plasticity, and their function has been implicated in neurological conditions. In this study, we investigated the role of HPCA in regulating NMDA receptor expression and function in mouse hippocampal neural precursor cells (mHNPCs). HPCA knockdown significantly reduced the expression of NMDA receptor-related genes, including , , , and selectively attenuated NMDA-induced calcium signaling. Transcriptomic analysis identified ELAV-like RNA-binding protein 3 (Elavl3), a neuron-enriched factor associated with neuronal activity, as a downstream candidate affected by HPCA knockdown. Consistently, Elavl3 suppression phenocopied HPCA deficiency, resulting in impaired NMDA receptor activity and reduced neuronal differentiation. Furthermore, hippocampal HPCA knockdown in vivo led to alterations in locomotor activity, contextual memory, and affective behaviors. Taken together, these findings demonstrate that HPCA supports NMDA receptor function and neuronal development, in part through Elavl3-associated pathways, and highlight HPCA as an important regulator of hippocampal function. - Source: PubMed
Publication date: 2026/03/06
Kang Min-JeongJung Sung JunSon HyeonHan Joong-SooPark Shin-Young