Ask about this productRelated genes to: SFTPB antibody
- Gene:
- SFTPB NIH gene
- Name:
- surfactant protein B
- Previous symbol:
- SFTP3
- Synonyms:
- SP-B
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-06
- Date modifiied:
- 2016-10-05
Related products to: SFTPB antibody
Related articles to: SFTPB antibody
- Postoperative progression remains a major challenge in resectable non-small cell lung cancer (rNSCLC), but its factors and mechanisms are not fully understood. Here, we found that 34%-43% of rNSCLC patients have lower surfactant protein B precursor (pro-SFTPB) expression in tumor compared to adjacent tissues, and this low expression of pro-SFTPB is associated with low major pathological response to neoadjuvant chemoimmunotherapy and recurrence in rNSCLC. and animal experiments have shown that pro-SFTPB inhibits cancer stemness and immune evasion in NSCLC, and promotes the efficacy of PD-1 inhibitors. Targeting eIF4F improves the sensitivity of NSCLC with pro-SFTPB low expression to PD-1 inhibitors. Mechanistically, eIF4F promotes pro-SFTPB expression, while pro-SFTPB inhibits the formation of eIF4F complex by binding to eIF4A1, thereby suppressing the translation c-myc and PD-L1 that promote cancer stemness and immune evasion. Finally, we demonstrated that the reduction of SFTPB mRNA in NSCLC disrupts the negative regulation of pro-SFTPB on eIF4F complex formation, leading to activation of the eIF4F translation pathway and ultimately promoting tumor stemness and immune escape. In conclusion, the downregulation of pro-SFTPB in rNSCLC is an important factor in activating eIF4F-mediated cancer stemness and immune evasion to induce resistance to immunotherapy and promote disease progression. - Source: PubMed
Publication date: 2026/04/23
Wen YonghengLuo HaoJi XintongZheng YushuZhang LiangJian DanChen JingZhang HongZhao Nan-NanJin HuaXu Cheng-XiongWang Ren-Tao - COVID-19 exhibits seasonal epidemics with high risk of mortality in vulnerable population. Identifying accurate parameters for predicting severity and adverse outcomes remains of great clinical significance. - Source: PubMed
Publication date: 2026/05/13
He LihengWei KaiLu JunyaoWei DongMeng XiaoxiaoChen PengZeng LingliJi PingZhang LianZhang XinxinWang RuilanQu JiemingXu JieChen YingyingSu BingYuan LiyunWang Ying - Human distal respiratory airway (DRA) cells are located in the smallest conducting airways of the human lung, specifically in the terminal and respiratory bronchioles, and represent a newly discovered cell type. Due to their absence in mice and the limited existing research on these cells, there is an urgent need to establish an in vitro model of human distal respiratory airways to study the role of such cells in respiratory diseases. - Source: PubMed
Publication date: 2026/05/12
Yin JiaxiangBi ZirongDai TiankaiMeng HaoShi FengSun JiaqiXu TaoLiu Huisheng - Due to the global obesity crisis, increasing numbers of women enter pregnancy with overweight or obesity. Their offspring are at greater risk of respiratory complications at birth due to metabolic changes that impact lung development that may reduce capacity for surfactant production. We hypothesize that a high-fat-high-energy diet (HF-HED) negatively impacts late gestation fetal lung development. - Source: PubMed
Publication date: 2026/04/27
Lock Mitchell CHuber Hillary FLi CunOrgeig SandraNathanielsz Peter WMorrison Janna L - To explore the relationship between surfactant protein B (SFTPB) gene expression and multiple biological processes in lung adenocarcinoma (LUAD) and construct a SFTPB-related gene signature for predicting LUAD prognosis. - Source: PubMed
Publication date: 2026/03/22
Ma ShanwuXu RuiLin ChutongNing YingzeHe HuayuTang JizhengJin LiangHe WeiXiong ZhenchengQiang Guangliang