Ask about this productRelated genes to: PON1 antibody
- Gene:
- PON1 NIH gene
- Name:
- paraoxonase 1
- Previous symbol:
- PON
- Synonyms:
- ESA
- Chromosome:
- 7q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: PON1 antibody
Related articles to: PON1 antibody
- Organophosphorus pesticides (OPPs) are widely used and have recently been linked to metabolic syndrome (MS). This study aimed to investigate the probable association between chronic OPP exposure and MS among farm workers in Sharkia Governorate, Egypt, and to assess the potential role of ). This comparative cross-sectional study included 140 participants, equally divided into OPP-exposed farm workers and non-exposed subjects. OPP exposure was confirmed by detecting plasma residues and cholinesterase activity. MS was diagnosed by assessing body mass index (BMI), waist circumference (WC), blood pressure, plasma glucose, serum insulin, and lipid parameters. Oxidative and inflammatory markers, including malondialdehyde (MDA), gamma-glutamyl transferase (GGT), ferritin, superoxide dismutase (SOD), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP), were measured. The mRNA expression of the and () genes was also investigated. In total, 60% of farm workers demonstrated MS, compared with 10% of non-exposed participants. Workers exhibited elevated oxidative and inflammatory indices and reduced and expression. positively correlated with high-density lipoprotein (HDL), SOD, and , while negatively correlating with glucose, insulin resistance (IR), low-density lipoprotein (LDL), triglycerides (TGs), MDA, GGT, ferritin, TNF-α, and hs-CRP. The study concluded that chronic OPP exposure was associated with increased oxidative stress and inflammation, reduced and expression, disturbed glucose and lipid metabolism, and increased IR. The observed associations between downregulation, metabolic disturbances, and oxidative and inflammatory markers suggest that dysregulation may represent a potential mechanistic link between chronic OPP exposure and MS. However, this proposed mechanism requires further validation. - Source: PubMed
Publication date: 2026/09/06
Sakr SamarEldaly Mai MElshamy Raghda AliAlmadani NouraNofal Hanaa AHammad Sherif AttiaEldesoqui MamdouhSoliman Wafaa Ibrahim - This pilot study aimed to assess the potential of cystatin C (Cys C) as a biomarker in non-Hodgkin lymphoma (NHL) and to explore its association with paraoxonase 1 (PON1) activity. - Source: PubMed
Mirjanić-Azarić BosaMijić SmiljanaRadić-Savić ZanaStanković SinišaMalčić-Zanić DraganaMihailović Egeljić NatašaStojisavljević ĐorđeIvetić BojanaBogavac-Stanojević Nataša - Atherosclerosis, a chronic inflammatory disease driven by lipid metabolism disorders and oxidative stress, remains a leading cause of mortality. Statins are effective but have significant side effects, necessitating exploration of safer herbal alternatives. Prosopis farcta and Scrophularia striata are two flavonoid-rich plants traditionally used for cardiac pain. The present study aims to compare the effects of extracts of these plants along with related parameters in male Wistar rats fed a High-Cholesterol Diet (HCD). - Source: PubMed
Publication date: 2026/09/11
Gharibi AghdasHeidarizadi SomayehAbbasi NaserHeidarbaigi KhadijehAzizi Monireh - Rheumatoid arthritis (RA) is characterized by inflammation and an increased risk for cardiovascular disease. Although it is known that metabolic disturbances alter macrophage metabolism, inflammatory responses and the ability to maintain immune homeostasis, these changes have not been well studied out of the context of atherosclerosis. Our aim was to investigate the effect of dyslipidemia caused by ApoE deficiency on macrophages and on antigen-induced arthritis in mice. Toward this aim, mice deficient in the ApoE gene were used which exhibit high total cholesterol (TC) levels distributed primarily in VLDL/IDL fractions, normal triglycerides and low HDL-C levels associated with distribution at lower densities and lower PON-1 activity. ApoE KO peritoneal macrophages had an M1-like polarization and an increased respiration rate. Importantly, ApoE KO mice developed more severe knee joint swelling compared to control mice. At the end of the arthritis protocol, spleen macrophages had increased expression of M1 cell surface markers. Simvastatin treatment reduced serum TC, increased HDL-C and PON-1 activity and improved HDL density. Additionally, treatment of ApoE KO mice with simvastatin limited the M1-associated cell surface markers on spleen macrophages and reduced arthritic joint swelling. Collectively, our findings support further investigation of lipid-modifying strategies in the context of inflammatory arthritis associated with dyslipidemia. - Source: PubMed
Publication date: 2026/09/19
Kakale AsiminaLazaridou DespoinaAxiotis IsidorosTzardi MariaKardassis Dimitris - High-density lipoproteins (HDL) are essential to alleviate the progression of atherosclerosis by mediating reverse-cholesterol transport, antioxidant and anti-inflammatory effects. We aimed to enhance the expression of endogenous HDL components, apolipoprotein A1 (APOA1) and antioxidant enzyme paraoxonase 1 (PON1), and to investigate their athero-protective effects. The CRISPR/dCas9 technology was used to activate the transcription of endogenous APOA1/PON1 in human hepatocytes (Huh7 line) and Apoa1/Pon1 in apoE mice. The expression of APOA1/PON1 genes was successfully upregulated in hepatocytes, and their proteins were secreted in the culture medium in the presence/absence of tumor necrosis factor-α (TNFα). APOA1-rich Huh7-derived conditioned medium exerted antioxidant and anti-inflammatory effects in TNFα-activated EA.hy926 endothelial cells. A single dose of the CRISPR/dCas9 plasmids i.v. injected in apoE mice increased the expression of hepatic Apoa1/Pon1 and their serum levels up to four weeks. FPLC analysis showed that increased serum APOA1 was distributed between HDL, LDL, and in lipid-free form. These mice also exhibited high levels of hepatic, gallbladder and feces cholesterol, in part due to the upregulation of hepatic scavenger receptor class-B1, cholesterol 7-alpha-hydroxylase, and ATP-binding cassette sub-family-G-member-8 transporter. In apoE mice with upregulated Apoa1/Pon1, no increased inflammatory stress or innate immune activation were detected, while lipid peroxides were decreased in PON1 mice. Of major interest, the area of aortic lipid deposits was halved in the treated mice. Our findings demonstrate the successful upregulation of endogenous Apoa1/Pon1 in apoE mice by using the CRISPR/dCas9 system, and highlight new mechanisms for APO1/PON1 anti-atherosclerotic action, explaining the reduction of aortic lipid deposits. - Source: PubMed
Publication date: 2026/09/18
Toma LauraBarbălată TeodoraHărătău Jessica Isabela CătălinaSanda Gabriela MariaFuior Elena ValeriaFenyo Ioana MădălinaNiculescu Loredan ŞtefanDăian Laura-MariaSasson ShlomoSima Anca VolumniaStancu Camelia Sorina