Ask about this productRelated genes to: IGFBP2 antibody
- Gene:
- IGFBP2 NIH gene
- Name:
- insulin like growth factor binding protein 2
- Previous symbol:
- IBP2
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-09
- Date modifiied:
- 2015-11-12
Related products to: IGFBP2 antibody
Related articles to: IGFBP2 antibody
- Subacute rumen acidosis (SARA) is a critical metabolic disorder in dairy ruminants that threatens their milk production. However, the mechanisms by which rumen fungi influence the susceptibility and tolerance of ruminants to SARA remain unclear. This study investigated the relationship between rumen fungal metabolic functions and host SARA tolerance by examining the rumen epithelial miRNA-mRNA correlations and further cell subtype variations affected by fungi. SARA-susceptible and SARA-tolerant goats were identified by monitoring the dynamic rumen pH during high-concentrate feeding. The abundance of anaerobic fungi and their cellulose and amino acid metabolic functions were reduced in SARA-susceptible goats, but the enrichment of , which is associated with increased thiamine metabolism, offers potential for SARA tolerance. Furthermore, this study revealed that negatively regulates the rumen epithelial chi-miR-17-26080 through enhanced thiamine metabolism, thereby reducing its inhibitory effect on insulin-like growth factor binding protein 2 (IGFBP2). The tolerance mechanism of SARA was further explored by adding thiamine to high concentrations, which revealed that the upregulation of IGFBP2 promoted rumen epithelial IGF1 recruitment and increased the content of IGF1, which activated the ERK and PI3K/AKT pathways, further increasing the expression of CDK4 and Cyclin A2 and promoting the rumen epithelial cells' proliferation. The increased number of rumen spinous and basal cells in SARA-tolerant goats enhances volatile fatty acids absorption in dairy goats, leading to improved SARA tolerance. These findings highlight the roles of rumen fungi and their produced thiamine in preventing SARA in ruminants by enhancing epithelial cell proliferation via the IGFBP2/IGF1 axis activation. - Source: PubMed
Publication date: 2026/02/24
Xu JingyiChen XiaodongMa YiRen JianrongXu GuanghaoZhang PeilinJia WenhaoDeng QuanqiuXiao YuquanYao JunhuWu Shengru - Chronic kidney disease is associated with dysregulation of the insulin-like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF-I, IGF-II, IGFBPs and progression of kidney dysfunction remains unclear. We evaluated how IGF/IGFBP profile relates to longitudinal changes in urinary albumin/creatinine ratio (ACR) and serum creatinine level in people with type 2 diabetes (T2D). - Source: PubMed
Publication date: 2026/04/17
Heald AdrianLllangasekera YasithaMatheou AndreasNarayanan Ram PrakashWhite StephenHabte-Asres HellenaLay AbigailShalamanova LilianaOllier WilliamHitman Graham AMallik RitwikaKalra Philip AWhyte MartinGibson J Martin - - Source: PubMed
Publication date: 2026/04/10
He SiyiLiang ChunyanHuang QiqiTan XiangMeng JialiQin XinlingZhang YanLiao JiaqingSu GengWang RenshengHuang Weimei - Emerging evidence suggests that mitochondrial-nuclear genomic crosstalk plays a role in phenotypic regulation. However, the molecular mechanisms underlying functional gene coordination and the dynamics of regulatory networks remain incompletely characterized. In the present study, we established bovine cybrid models harboring isogenic nuclear genomes but distinct mitochondria adapted to different environmental oxygen tensions. Multi-omics analyses identified 437 DEmRNAs, 48 DElncRNAs, 169 DEcircRNAs, 154 DEmiRNAs, and 91 DEPs between the isonuclear cybrids with different mitochondrial backgrounds. Reconstruction of the regulatory network elucidated two ceRNA networks consisting of 112 mRNAs, 11 miRNAs, and 21 lncRNAs. Cross-omics integrative analysis revealed 37 concordantly regulated targets that exhibited significant expression alterations at both transcriptional and translational levels, including DSG3, DSC2, ISG15, and IGFBP2. Functional enrichment analysis indicated that these molecular determinants were critically involved in steroid biosynthetic processes, cGMP-PKG signal transduction, and NLR-mediated inflammatory responses. Collectively, our findings demonstrate that mitogenomes orchestrate cellular energy homeostasis and hypoxic adaptation through synergistic regulation of nuclear gene expression and post-translational modifications. - Source: PubMed
Publication date: 2026/04/07
Wang JikunLiu ZhijieHuang CiPeng WeiSun XiaoxuWang HuiChai ZhixinWu ZhijuanYue BinglinCai XinZhong JinchengZhao XingboXiang Hai - Hypodontia, defined as the congenital absence of teeth, may reflect underlying disturbances in molecular pathways regulating odontogenesis. This pilot cross-sectional study aimed to investigate whether systemic levels of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and human growth hormone (HGH) differ between individuals with congenital bilateral absence of mandibular second premolars and individuals with normal dentition. - Source: PubMed
Publication date: 2026/01/12
Alenzi Rana HAlshammari Abdullah FAbdullah Mashan LAldukhyeel Sultan MAldosari Mohammed NAljameel Yousef I