Ask about this productRelated genes to: PCSK5 antibody
- Gene:
- PCSK5 NIH gene
- Name:
- proprotein convertase subtilisin/kexin type 5
- Previous symbol:
- -
- Synonyms:
- PC5, PC6, SPC6
- Chromosome:
- 9q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-19
- Date modifiied:
- 2015-09-03
Related products to: PCSK5 antibody
Related articles to: PCSK5 antibody
- Colorectal cancer (CRC) is a leading cause of cancer mortality. The Golgi apparatus (GA) mediates protein glycosylation and secretion, and its dysfunction is implicated in cancer invasion and immune evasion [1]. The prognostic relevance of GA-related genes in CRC remains unclear. - Source: PubMed
Publication date: 2026/05/09
Wu Shuaiyi - The prevalence of Type 2 diabetes mellitus (T2DM) is rapidly increasing in India, yet molecular markers that reflect early disease susceptibility remain limited. Epigenetic modifications such as DNA methylation may reflect early metabolic vulnerability preceding overt dysglycemia. In this study, we examined genome-wide DNA methylation patterns in a pilot subset nested within a prospective Indian cohort using Nanopore sequencing and assessed their associations with previously identified metabolite predictors from the same cohort. - Source: PubMed
Publication date: 2026/04/16
Satheesh GopikaAsokan Aneesh KVijayakumar GadadharanRajavelu ArumugamRao Sudha NarayanaSivakumar Krishnankutty ChandrikaJaleel Abdul - Congenital diaphragmatic hernia (CDH) is a developmental anomaly associated with high mortality and morbidity, primarily attributed to accompanying pulmonary hypoplasia. Genetic factors are crucial in the etiology and pathogenesis of CDH, with various copy number variations (CNVs) and gene sequence variants implicated in this malformation. Previous studies have underscored the importance of retinoic acid (RA) signaling pathways and related genes. Nonetheless, the complexity of diaphragmatic development involving cell migration, cytoskeleton organization, and myogenesis suggests that candidate CDH genes extend beyond the RA pathway. To explore novel candidate gene variants and their roles in CDH, we performed whole exome sequencing (WES) in CDH-affected fetuses. - Source: PubMed
Somayyeh Heidargholizadeh GTurgut Gozde TutkuAltunoglu UmutSivrikoz Tugba SaracUyguner Zehra OyaBasaran SeherKaraman BirsenGulec Cagri - Brown adipocytes are vital in cancer's emergence and progression. However, such significance of brown adipocytes-related genes (BARGs) in colorectal cancer (CRC) still awaits exploration. The potential prognostic mechanisms of BARGs in CRC were aimed to be explored in this study. - Source: PubMed
Publication date: 2025/12/13
He HuaShengWang YuanbiaoKuang HuilanTian LinghanWang ZihanWang LanLv FenghongLiu ZhixiWu WeiZhang Yi - The competing endogenous RNA hypothesis offers new insights into tumour progression, yet its role in posttreatment nasopharyngeal carcinoma relapse remains unclear. This study constructed ceRNA networks to identify molecular markers associated with NPC relapse. Three pairs of primary and relapse NPC tissue samples, along with their matched adjacent tissues, were collected for the RNA and miRNA sequencing, screened and identified relapse-related specific differentially expressed genes. We identified relapse-specific differentially expressed genes and functional analyses revealed enrichment in translation, biosynthesis, metabolism, TCA cycle, cell cycle, p53 signalling and immune pathways. Then these relapse-associated differentially expressed mRNAs, lncRNAs, and miRNAs were utilised to construct regulatory networks, resulting in a ceRNA network comprising 813 mRNAs, 143 lncRNAs, and 24 miRNAs, along with a survival-associated subnetwork of 23 mRNAs. Key mRNAs, such as UBC, PLA2R1, PTPRO, SMC5, PFN2, TIMM17B, NT5E and PCSK5, were validated via qPCR in NPC cell lines and tissues. To our knowledge, this is the first study to construct a comprehensive ceRNA network specifically for posttreatment recurrent NPC. These findings highlight the ceRNA network as a valuable framework for elucidating the mechanisms of NPC relapse and for identifying potential biomarkers for prognosis and therapeutic targets in recurrent nasopharyngeal carcinoma. - Source: PubMed
Liu QihongLu JingxiaoWang ZhiqiangLi QingmingWu JianhuiLyu KexingMiao BeipingLei WenbinNie GuohuiFan Xiaoqin