Ask about this productRelated genes to: VSTM2A antibody
- Gene:
- VSTM2A NIH gene
- Name:
- V-set and transmembrane domain containing 2A
- Previous symbol:
- VSTM2
- Synonyms:
- MGC33530
- Chromosome:
- 7p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-09-12
- Date modifiied:
- 2019-03-21
Related products to: VSTM2A antibody
Related articles to: VSTM2A antibody
- Gastric cancer (GC) is a major cause of cancer mortality and remains difficult to diagnose early and treat effectively. Although transcriptomic profiling has defined extensive molecular heterogeneity, many studies are not anchored to clinicopathological variables or interpreted in the context of tissue-level pathobiology. We applied an integrative transcriptomic and network-based framework to identify molecular signatures that reflect structural and biochemical reprogramming of gastric tissue during malignant transformation. RNA-seq expression profiles and clinical annotations were analyzed using non-parametric differential expression filtering, functional enrichment, and protein-protein interaction network modeling. Expression patterns were further evaluated across clinicopathological strata (stage, grade, nodal status, and metastasis) and by network-informed clustering. Across clinical strata, GC showed a consistent signature of developmental reactivation and loss of gastric epithelial identity. Developmental regulators, most prominently HOX-cluster genes and the histone variant HIST1H3J, were upregulated, consistent with epigenetic/chromatin reprogramming. In parallel, gastric differentiation and secretory lineage markers (ATP4A, KCNE2, PTF1A, VSTM2A) were persistently downregulated, reflecting suppression of parietal/ductal programs and altered metabolic/secretory function. ADIPOQ demonstrated stage-dependent repression and was associated with poorer survival, supporting a context-dependent prognostic role. Enrichment and network analyses also highlighted FGFR-centered signaling as a dominant oncogenic axis linked to proliferation and invasion. This study identifies a molecular pathology framework in which GC progression involves coordinated chromatin-level developmental reprogramming and sustained loss of gastric differentiation programs, accompanied by FGFR-driven oncogenic signaling and stage-dependent metabolic disruption. These signatures provide candidate diagnostic and prognostic biomarkers and support prioritization of therapeutically actionable pathways in GC. - Source: PubMed
Publication date: 2026/05/21
Mottaghi-Dastjerdi NegarSoltany-Rezaee-Rad Mohammad - Danzhou chicken (DZC) is a native chicken breed endemic to Hainan Island, which is renowned for its superior meat quality and strong disease resistance. Prolonged geographical isolation, coupled with natural and artificial selection events in response to the tropical environment, has significantly transformed the behavior, appearance, and economically important traits of DZC. However, the relatively small size of its conservation population has impeded research on the genetic mechanisms of specific traits and population genetics, exerting an adverse influence on resource conservation and commercial development. This study aims to investigate the formation mechanisms of environmental adaptability through a scanning analysis of population selection in DZC. - Source: PubMed
Publication date: 2026/02/02
Xie X FFan J WWang Z YZhong Z QPan D YShi L GXiao QHou G Y - Proteomic biomarkers for Parkinson's disease (PD) are critical for identifying new targets for disease-modifying therapies and expanding our understanding of disease pathophysiology. - Source: PubMed
Publication date: 2025/08/05
Oh SungtaekJung JaehunKim JinhyeokJang YuraBakker Catherine CPantelyat Alexander YZhang ZhenDawson Ted MNa Chan HyunRosenthal Liana S - (1) Background: The Hulunbuir sheep is a Chinese local sheep breed with good meat quality and exceptional cold-stress resilience. However, the growth performance of the Hulunbuir sheep is lower when compared to that of commercial breeds. Growth traits such as body weight and body size are critical, as they directly influence the meat production in sheep farming. Employing genome-wide association studies can identify SNPs and candidate genes related to growth traits in Hulunbuir sheep. (2) Methods: The chest girth (CG), cannon circumference (CC), hip width (HW), body height (BH), and body length (BL) of 799 Hulunbuir sheep were measured. All the animals were divided into three groups according to their age (Group 1: 0-6 months old, Group 2: 12-24 months old, Group 3: 48-70 months old). Subsequently, genotyping was carried out using the Sheep 40K liquid chip. A multi-trait genome-wide association study (MT-GWAS) was performed for each group of animals. (3) Results: A total of three candidate genes (, , ) associated with body size traits were identified through GWAS analysis and KEGG pathway enrichment for Group 2. (4) Conclusions: This study identified three candidate genes related to body size in Hulunbuir sheep, providing genetic targets for marker-assisted selection (MAS) in Hulunbuir sheep. - Source: PubMed
Publication date: 2025/03/31
Yang HengqianLi TingtingZhang NaChen JieranZhang YutingPeng ShiyuZhou LishengMa RunlinZhang ZhichaoLiu QiuyueWang HaitaoHe Jianning - Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear. We have previously identified V-set and transmembrane domain-containing protein 2A (VSTM2A) as a factor promoting fat cell development in vitro. Whether VSTM2A impacts adipose tissue and systemic metabolism in vivo is still unknown. - Source: PubMed
Publication date: 2025/02/16
Al Dow ManalSecco BlandineMouchiroud MathildeRochette MarianneGilio Gustavo RMassicard MickaelHardy MarilouGélinas YvesFestuccia William TMorissette Mathieu CManem Venkata S KLaplante Mathieu