Ask about this productRelated genes to: IGFBP7 antibody
- Gene:
- IGFBP7 NIH gene
- Name:
- insulin like growth factor binding protein 7
- Previous symbol:
- -
- Synonyms:
- MAC25, IGFBP-7, PSF, FSTL2
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-02
- Date modifiied:
- 2015-11-12
Related products to: IGFBP7 antibody
Related articles to: IGFBP7 antibody
- Liver transplantation is the definitive treatment for end-stage liver disease; however, postoperative acute kidney injury (AKI) affects 30%-70% of recipients and significantly worsens prognosis. The pathogenesis involves insufficient preoperative hepatorenal reserve, intraoperative hemodynamic instability, and immunosuppressant nephrotoxicity. Despite the evolution of diagnostic criteria from RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) and AKIN (Acute Kidney Injury Network) to KDIGO (Kidney Disease: Improving Global Outcomes), creatinine-based markers remain insensitive and delayed, hindering early detection. Diverse predictive models have been developed to improve risk stratification, including conventional scoring systems (Model for End-Stage Liver Disease, Acute Physiology and Chronic Health Evaluation-II, and Sequential Organ Failure Assessment), multivariate logistic regression, and machine learning algorithms such as artificial neural networks, random forest, and XGBoost, which can achieve area under the curve values of 0.75-0.91. However, clinical implementation remains limited by inconsistent variable definitions and insufficient external validation. Concurrently, novel molecular biomarkers have shown promise for early prediction. Tubular injury markers (NGAL and KIM-1) and cell cycle arrest biomarkers ([TIMP-2]×[IGFBP7]) can detect renal injury within 0-6 h, whereas cystatin C provides reliable assessment at 6-48 h post transplantation. Additional candidates include inflammatory mediators (IL-18 and soluble ST2), endothelial dysfunction markers (soluble Syndecan-1 and endothelin-1), and emerging molecules such as proenkephalin, C-C motif chemokine ligand 14, C-X-C motif chemokine receptor 10, and miR-21-5p. Integrating biomarkers across temporal windows with mechanistic pathways enhances predictive accuracy and may facilitate stage-specific interventions. This review synthesizes recent advances in predictive models and molecular biomarkers for AKI following liver transplantation, evaluating their performance, limitations, and translational potential while identifying future directions for improving patient outcomes. - Source: PubMed
Publication date: 2026/04/16
Bin BingChen YuxiaoLi ShijianWu Jihua - Secondary lymphedema is accompanied by a persistent chronic inflammatory response and remodeling of the immune microenvironment. Among them, CD4⁺ T cells and their functional subgroups play a crucial role. This study identified potential candidate molecules in the CD4⁺ T cell-related immune microenvironment, providing new research clues for subsequent mechanism-oriented intervention studies. - Source: PubMed
Publication date: 2026/05/15
Huang XiaoxiaoLu ChuanTan ZhibiaoXu Jianwen - - Source: PubMed
Publication date: 2026/05/11
Sokmen Okan - Biomarkers have the potential to improve risk prediction beyond clinical characteristics. We examined the association of four emerging cardiovascular biomarkers [angiopoietin 2 (Angpt2), bone morphogenetic protein 10 (BMP10), fibroblast growth factor 23 (FGF23), insulin-like growth factor binding protein 7 (IGFBP7)] in comparison with N-terminal pro B-type natriuretic peptide (NT-proBNP) across the disease course of atrial fibrillation (AF). - Source: PubMed
Ohlrogge Amelie HEngler DanielSchlieker PatriciaSeum FerdinandRosebrock KimNebel NicoleCsengeri DoraFabritz LarissaZiegler AndréBlankenberg StefanKirchhof PaulusZeller TanjaSchnabel Renate B - We tested the hypotheses that sodium bicarbonate (SB) supplementation improves performance, reduces markers of acute kidney injury (AKI) risk, and increases markers of acute gastrointestinal injury (AGI) during repeated sprints in the heat. - Source: PubMed
Publication date: 2026/05/14
Specht Jonathan WRamirez MarissaRaef JenniferSchwartz MackenzieBailly Alyssa RChavez OscarKumbasar OzanDawson Jade XApodaca JessicaFreire RaulAtkins Whitley Cde Castro Magalhães FlávioSiegler JasonAmorim Fabiano T