Ask about this productRelated genes to: SPINK1 antibody
- Gene:
- SPINK1 NIH gene
- Name:
- serine peptidase inhibitor, Kazal type 1
- Previous symbol:
- -
- Synonyms:
- Spink3, PCTT, PSTI, TATI
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1988-06-27
- Date modifiied:
- 2015-03-02
Related products to: SPINK1 antibody
Related articles to: SPINK1 antibody
- Chronic pancreatitis (CP) is a fibro-inflammatory syndrome associated with environmental, genetic, autoimmune, and metabolic factors. Although the main burden of CP is chronic pain and pancreatic insufficiency, epidemiological data indicate that CP patients are at significantly higher risk of developing pancreatic ductal adenocarcinoma (PDAC). CP is a disease that requires complex management based on reducing the severity of symptoms, as there is no curative treatment available. Idiopathic chronic pancreatitis (ICP) is diagnosed after ruling out other possible causes and remains the second most common type of CP-8%-30% of cases. A distinction is made between early-onset ICP (EO-ICP) and late-onset ICP (LO-ICP) based on the age of onset. ICP is characterized by a milder course than CP of other etiologies. In particular, considering the subtypes of ICP, there is a tendency that pain occurs significantly more frequently in EO-ICP compared to alcoholic CP (ACP) and LO-ICP. In turn, diabetes and exocrine pancreatic insufficiency seem to develop much faster in patients with LO-ICP than in patients with ACP and EO-ICP. However, in CP associated with genetic causes, especially mutations in the serine protease 1 () and serine protease inhibitor Kazal type 1 () genes, a significantly higher PDAC risk is observed than in both ICP and ACP. Moreover, patients with ICP are considerably less likely to require intensive pain treatment, including gabapentinoids and opioids. All this translates into a lower frequency of hospitalizations and need for interventional treatment, both endoscopic and surgical. Given that ICP represents a substantial proportion of CP cases, this review highlights possible factors underlying the idiopathic etiology, clinical presentation, and diagnostic features. It summarizes the clinical management of ICP, including the treatment of pain, steatorrhea, diabetes, as well as pancreatic cysts and the risk of PDAC, highlighting differences in treatment patterns and the relative use of specific therapeutic modalities in comparison to other types of CP. - Source: PubMed
Publication date: 2026/04/20
Knopczyk KingaMałecka-Wojciesko Ewa - Hereditary chronic pancreatitis (CP) is associated with elevated risk of pancreatic ductal adenocarcinoma (PDAC), but the specific contributing genes and their associated risk magnitudes remain incompletely defined. We aimed to investigate whether pathogenic germline variants (PGVs) in all 11 known CP-associated genes (CASR, CEL, CFTR, CLDN2, CPA1, CPB1, CTRC, PNLIP, PRSS1, SPINK1, TRPV6) predispose to PDAC and to quantify their risk estimates. - Source: PubMed
Publication date: 2026/04/20
Antwi Samuel ORabe Kari GCarlson Erin ESicotte HuguesBamlet William RMills Krystal CKonikoff Tom McWilliams Robert ROberg Ann LMajumder Shounak
- Source: PubMed
- We report a multicystic intrahepatic neoplasm in a 54-year-old Japanese woman, representing a previously unrecognized subtype. Grossly, the lesion was a well-demarcated multicystic tumor with focal papillary projections. Histologically, the cysts were lined by columnar to cuboidal neoplastic cells with brush border-like luminal microvilli, abundant granular eosinophilic cytoplasm, and small round nuclei. The cystic lumina contained colloid-like secretion, and bile-filled glands were occasionally observed. The septa were composed of thin hepatocellular parenchyma. Immunohistochemically, the tumor cells were positive for CD10, CK7, CK19, EpCAM, and SPINK1 and negative for HepPar1, MUC1, MUC2, MUC5AC, and MUC6. Whole-exome sequencing identified a pathogenic somatic KRAS p.G12V variant. RNA sequencing detected no PRKACA/B fusions. Single-cell spatial transcriptomics demonstrated that tumor cells clustered most closely with septal and medium-sized interlobular bile ducts. Gene set activity analysis showed significant suppression of gene sets downregulated by KRAS activation and upregulation of KRAS dependency signature gene sets in tumor cells. These findings distinguish this lesion from established entities of intrahepatic biliary cystic neoplasms, including intraductal papillary neoplasm, intraductal tubulopapillary neoplasm, intraductal oncocytic papillary neoplasm, and mucinous cystic neoplasm. We propose the designation "eosinophilic biliary cystic neoplasm of the liver" for this distinct intrahepatic biliary neoplasm. - Source: PubMed
Tanaka MarikoKoinuma DaizoHinata MunetoshiTakeshita KimikoYasunaga YoichiSakuma KeiTakamoto TakeshiNishioka YujiroHasegawa KiyoshiNakai YudaiUshiku Tetsuo - A trypsin inhibitor, the serine peptidase inhibitor, Kazal type 1 (SPINK1), a secreted protein, has been identified in recent years as contributing to the advancement of specific cancer types. Lung cancer is a common class of malignant tumors. However, the role of SPINK1 in lung cancer is unknown. This study aimed to investigate the profound mechanism of SPINK1 in lung cancer. - Source: PubMed
Publication date: 2026/03/19
Yue GuojunYue LingyunChen YanYang HengChen XiZhao YaqianXing ShiyunShen GangZhou LeiZhang YuBai Yiju