Ask about this productRelated genes to: ApoE antibody
- Gene:
- APOE NIH gene
- Name:
- apolipoprotein E
- Previous symbol:
- AD2
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: ApoE antibody
Related articles to: ApoE antibody
- Blood-based biomarkers offer a promising, minimally invasive approach to Alzheimer's disease (AD) diagnosis, yet validation in admixed populations remains limited. We investigated whether plasma biomarkers predict CSF-defined AD pathology in a Brazilian cohort. - Source: PubMed
Publication date: 2026/04/21
Rizzi LiaraRibeiro Isadora Cristinada Rocha Silva Marjorie CristinaAventurato Ítalo KarmannSantos Luis EduardoDos Santos Silva Ananssa MaíraPinheiro Thaís LopesFernandes Gustavo Bruniera PeresDe Felice Fernanda GuarinoBalthazar Marcio L F - Mitochondria-associated ER membranes (MAMs) are critical hubs for Ca signaling, energy homeostasis, and autophagy. Their dysregulation contributes to lipid-driven cardiovascular diseases; however, selective and reversible strategies to modulate MAM-associated protein-protein interactions (PPIs) remain limited. This study aimed to develop a targeted peptide to disrupt the IPR-GRP75-VDAC1 complex and evaluate its therapeutic efficacy in atherosclerosis. - Source: PubMed
Publication date: 2026/04/16
Ha JungminKo MinjeongLim Yong-BeomKwon Ho Jeong - The apolipoprotein E (APOE) 4 allele is the primary genetic driver of late-onset Alzheimer's disease (AD), a complex neurodegenerative disorder characterized by the interplay of amyloid-β (Aβ) accumulation, tau pathology, neuroinflammation, and lipid metabolism dysfunction. Emerging evidence suggests that these pathological hallmarks are fundamentally linked to deficits in neuroplasticity and the continuous turnover of synapses. A growing body of evidence highlights APOE lipidation, a process by which APOE is loaded with lipids via cellular transporters such as ABCA1, as a key determinant of APOE function and toxicity. While lipidated APOE2 and APOE3 facilitate cholesterol transport and Aβ clearance, lipid-poor APOE4 is associated with impaired receptor-mediated clearance of Aβ, disrupted microglial function, increased neuroinflammation, and synaptic deficits. Furthermore, APOE lipidation status differentially influences tau pathology, potentially linking cholesterol dysregulation to tau hyperphosphorylation and aggregation. Here, we systematically examine the mechanistic role of APOE lipidation in AD pathogenesis, focusing on its effects on Aβ and tau pathology. We also discuss how dysregulation of APOE lipidation may serve as a central molecular mechanism connecting APOE4 to multiple pathological hallmarks of AD. This review examines how APOE lipidation is involved in amyloid-related and tau pathology in AD. - Source: PubMed
Publication date: 2026/04/08
Zhang Dong YanWang JianDokholyan Nikolay V - Older adults with epilepsy have a 2- to 4-fold increased risk of dementia, including Alzheimer's disease (AD), yet underlying mechanisms remain poorly defined. The NIA-AA classifies AD using amyloid (A), tau (T), and neurodegeneration [(N)] biomarkers. We applied this framework to characterize AT(N) profiles and clinical correlates in epilepsy. - Source: PubMed
Publication date: 2026/04/27
Arrotta KayelaWilliams McKennaThompson Nicolas RBangen Katherine JReyes AnnyZawar IfrahPunia VineetWang IreneShih Jerry JBekris Lynn MFerguson LisaAlmane Dace NJones Jana EHermann Bruce PBusch Robyn MMcDonald Carrie R - -ε4 is the strongest common genetic risk factor for Alzheimer's disease (AD), yet many carriers remain cognitively unimpaired into late life. We tested whether a protected-ε4-first proteomic approach could identify plasma proteins associated with delayed clinical onset among ε4 carriers. - Source: PubMed
Publication date: 2026/05/01
Guen Yann LePark JunyoungPeña-Tauber AndrésGreicius Michael D