Ask about this productRelated genes to: PAFAH1B3 antibody
- Gene:
- PAFAH1B3 NIH gene
- Name:
- platelet activating factor acetylhydrolase 1b catalytic subunit 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-03
- Date modifiied:
- 2015-11-16
Related products to: PAFAH1B3 antibody
Related articles to: PAFAH1B3 antibody
- Bladder cancer (BCa) is a highly prevalent urological malignancy and one of the most frequently occurring cancers worldwide, necessitating the development of diagnostic and therapeutic biomarkers. This study aimed to explore candidate genes that may be involved in the carcinogenesis of BCa. - Source: PubMed
Publication date: 2026/07/18
Sajjadi SanaRamezani AminAlavimanesh SajadAlipoor HojatTakhshid Mohammad Ali - Gastric cancer has remained as a top ranked human malignancy showing both high morbidity and mortality, especially in Asian countries. Recent advances have revealed actionable targets for clinical gastric cancer therapy, including epidermal growth factor receptor 2 (HER2) and vascular endothelial growth factor receptor (VEGFR), thus calling for further investigation of potential therapeutic targets. Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) functions to remove the acetyl group from platelet-activating factor and is implicated in multiple diseases including cancer. However, the exact roles and underlying mechanisms of PAFAH1B3 in gastric cancer are incompletely investigated. By combining bioinformatic and gastric cancer tissue analyses, we confirmed that PAFAH1B3 was upregulated in gastric cancer and reversely correlated with patient prognosis showing significant association with tumor stages and metastasis. PAFAH1B3 knockdown rendered suppressed proliferation and migration, but enhanced apoptosis of gastric cancer cells. Transcriptomic profiling of control and PAFAH1B3 knockdown cells revealed VEGFA as a downstream effector, the overexpression of which effectively rescued defects imposed by PAFAH1B3 knockdown. Further investigation showed that PAFAH1B3 coordinated with the transcription factor E2F8 to promote VEGFA transcription. Importantly, in xenograft animal models, PAFAH1B3 overexpression significantly enhanced tumorigenesis, while VEGFA knockdown effectively suppressed gastric cancer xenograft growth. Therefore, our findings suggest that the PAFAH1B3/E2F8/VEGFA pathway plays an important role in gastric cancer progression, which can be targeted to design novel therapeutic strategies against gastric cancer. - Source: PubMed
Publication date: 2026/05/14
Liu ZhenhuaXiu YufangZhang ShanniJiang KeqiuZhang XiaoWang HaoDu JianyuZhang YingqiuKong Meng - Assisted reproductive technologies, such as fertilization, remain inefficient in camelids, largely due to gaps in understanding the molecular interactions that regulate sperm capacitation. Fertilization requires not only viable spermatozoa but also the precise modulation of capacitation by the peri-ovulatory microenvironment, including follicular fluid (FF) and oviductal fluid (OF). In this study, spermatozoa were incubated in Fert-TALP medium supplemented with FF or OF, and both functional outcomes and proteomic remodeling were assessed. Sperm treatments were evaluated in five independent biological replicates per individual (three individuals), with triplicate proteomics performed. FF ( = 20) was collected from pre-ovulatory follicles (7-9 mm) and OF ( = 10) from the corresponding ipsilateral oviducts, thereby reflecting the environment encountered by sperm in the female reproductive tract following mating. Incubation with FF enhanced progressive motility by 72%, rapid progressive motility by 169%, viability by 30%, and acrosome responsiveness by 30%, and was associated with a proteomic shift involving ~12% of proteins ( < 0.05). These included factors implicated in zona pellucida binding (LYPD4, PGK1, ANXA2, and TCP1 complex members) and galactose metabolism (MAOA, AKR1B1, GLA, and HK1). The enriched processes included glycolysis/gluconeogenesis, cytoskeletal reorganization, and protein maturation, all consistent with sperm capacitation. By contrast, sperm incubated with OF showed an underrepresentation of capacitation-related pathways, including the proteasome complex, sperm fibrous sheath, and TCA cycle. Moreover, the OF proteome ( = 2) revealed decapacitation-associated factors such as PEBP1 and PAFAH1B3, which likely stabilize membranes and delay premature capacitation. Together, these findings demonstrate complementary yet contrasting roles of FF and OF in modulating sperm physiology: FF acting as a capacitating medium, and OF providing a stabilizing environment. This study presents the first partial proteome of capacitated alpaca sperm together with matched reproductive fluids, providing mechanistic insights with direct implications for improving assisted reproduction in camelids. - Source: PubMed
Publication date: 2025/11/06
Torres Hualla Edith AMartiarena AlbaBuglio Ballesteros María GabrielaMedina Rojas Maribel FortunataRivera Chino CristianGandarillas Espezua DanielArgañaraz Martin E - Bladder cancer (BCa), the most prevalent malignancy of the urinary system, is strongly associated with environmental factors including smoking and industrial chemical exposure. Although previous studies have explored the relationship between various environmental pollutants and BCa mechanisms, there is still a need for an in-depth analysis of the specific effects and particular roles of these pollutants. This study investigates the molecular mechanisms linking environmental pollutant exposure to bladder carcinogenesis through a multi-omics integrative analysis that systematically elucidates the environment-gene interaction network. By integrating transcriptomic data from multiple BCa cohorts with the Comparative Toxicogenomics Database (CTD) gene-chemical-disease network, we identified 168 environment-responsive differentially expressed genes (DEGs). Subsequent Mendelian Randomization (MR), Summary-data-based MR (SMR), and colocalization analyses revealed three causal hub genes (CTSK, GSTM5, and PAFAH1B3; PP4 > 0.70) and associated them with 34 high-risk environmental pollutants. Molecular docking demonstrated strong binding affinities between these hub genes and more than ten pollutants, with bisphenol A, sodium arsenite, and tetrachlorodibenzodioxin (TCDD) differentially regulating distinct targets: significantly suppressing tumor-suppressor genes CTSK (OR = 0.91, p = 0.004) and GSTM5 (OR = 0.77, p < 0.001) while upregulating the oncogenic factor PAFAH1B3 (OR = 2.11, p < 0.001). Single-cell RNA sequencing (scRNA-seq) analysis and Human Protein Atlas (HPA) database validation confirmed tissue-specific expression patterns of these hub genes in bladder tissues. Our findings establish a comprehensive evidence chain connecting "environmental pollutant exposure - gene interaction - bladder carcinogenesis," providing novel biomarkers and preventive targets for molecular subtyping and precision prevention of environmentally associated BCa. - Source: PubMed
Publication date: 2025/10/18
Zhu GuangqiangTan ChunlinLi Yugen - High-altitude environments are characterised by extreme conditions, including hypoxia, low temperatures, and intense ultraviolet radiation. Mammals inhabiting these environments have evolved unique adaptive mechanisms, the study of which elucidates survival strategies and evolutionary pathways under extreme conditions. Understanding how native high-altitude animals respond to such environments is highly important. This study investigated the high-altitude adaptation mechanisms of the five-toed jerboa (Orientallactaga sibirica) distributed in Qinghai Province (4229 m) and Hebei Province (498 m), China, through comparative transcriptomic analysis of heart, lung, and kidney tissues. The results revealed greater mRNA transcriptional differences in the lung tissue than in the heart and kidney tissues of high-altitude jerboas, indicating heightened lung sensitivity to high-altitude conditions. In lung tissue, high-altitude jerboas show differential expression of genes related to the Complement and Coagulation cascades, Heme binding, Oxidation-reduction process (such as MASP1, A2M, SERPING1, CD55, FGA, C5AR1, and KNG1), which may be associated with modulating immune functions to mitigate hypobaric hypoxia, intense radiation, and cold-induced damage and reducing thrombosis and inflammation risks. Heart tissue exhibits differential expression of Oxidative phosphorylation and Lipid metabolism genes (such as NDUFC2, NDUFA3, NDUFS4, COX4I2, PAFAH1B3, SGMS2 and PPAR2B), which may help maintain energy equilibrium under hypoxic and cold challenges. Kidney tissue exhibits differential enrichment of pathways such as arachidonic acid metabolism and steroid hormone biosynthesis mediated by genes including CYP4A11, CYP2C29, GPX2, PTGDS, CBR1, and UGT2B31, which may help coordinate vascular regulation, immune response, and oxidative balance to maintain systemic homeostasis. These pathways and genes are differentially enriched and expressed between high-altitude and low-altitude five-toed jerboas, which may be candidates for further functional studies of plateau environmental adaptability. Our findings provide candidate genes and pathways for intraspecies adaptations across microenvironments and highlight the need for further functional validation. - Source: PubMed
Publication date: 2025/10/07
Sun Shan-ShanZhang Hao-TingYan Hai-WenKang Xiao-YuBuren Qi-QigeWang Qian-ChengMing MingFeng Jie-RuZhu NaLi XinLing YuZhang DongWu Xiao-DongYuan ShuaiFu He-Ping