Ask about this productRelated genes to: MPPED2 antibody
- Gene:
- MPPED2 NIH gene
- Name:
- metallophosphoesterase domain containing 2
- Previous symbol:
- C11orf8
- Synonyms:
- 239FB, D11S302E, Hs.46638, FAM1B, dJ873F21.1, dJ1024C24.1
- Chromosome:
- 11p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-08-06
- Date modifiied:
- 2016-10-05
Related products to: MPPED2 antibody
Related articles to: MPPED2 antibody
- Manganese superoxide dismutase (MnSOD) functions as an influencing factor for the progression of clear cell renal cell carcinoma (ccRCC). The MnSOD activity is directly influenced by manganese metabolism. Therefore, our goal was to evaluate the prognostic value of manganese metabolism in ccRCC. Public ccRCC transcriptomic datasets were analyzed. Manganese metabolism-related prognostic genes were identified through univariate Cox regression combined with machine learning approaches. These genes were utilized to develop a risk model, and a nomogram was constructed using independent prognostic factors. Immune microenvironment evaluation revealed differences between risk groups, while single-cell RNA-sequencing (scRNA-seq) characterized key cell populations and prognostic gene expression, validated by RT-qPCR. MPPED2 and PLAU were identified as prognostic genes, with both the risk model and nomogram demonstrating high predictive accuracy. Analysis of 22 immune cell types revealed significant differences in immune infiltration between risk groups, while scRNA-seq data identified epithelial cells as the key cell type involved. RT-qPCR analysis revealed that the ccRCC group demonstrated notably reduced expression levels of MPPED2 and PLAU. This work combined bulk transcriptome and single-cell sequencing to preliminarily pinpoint MPPED2 and PLAU as potential ccRCC prognostic genes, highlight the essential function of epithelial cells, and offer new potential therapeutic targets for ccRCC. - Source: PubMed
Publication date: 2026/06/13
Chen YuhaoZhao XiaodongZhou YulinLiu ShouyongSheng ZhengchengXu SongDong JieLiu WeiZhou Wenquan - Clear cell renal cell carcinoma (ccRCC) is characterized by high recurrence and metastatic potential, leading to poor clinical outcomes. There is a critical need to identify reliable prognostic biomarkers and therapeutic targets to improve patient stratification and personalized treatment. - Source: PubMed
Publication date: 2026/01/28
Fu CongSun LinZhou TongBi Yanzhi - Increasing evidence suggests that the biological activity of trophoblasts and M1-type macrophages plays a crucial role in recurrent spontaneous abortion. However, detailed mechanistic studies on the intercellular communication between these two cells at the maternal-fetal interface are not clear. - Source: PubMed
Tang CenQi Hongbo - Castration-resistant prostate cancer (CRPC) marks the advanced phase of prostate malignancy, manifested through two principal subtypes: castration-resistant adenocarcinoma (CRPC-adeno) and neuroendocrine prostate cancer (NEPC). This study aims to identify unique central regulatory genes, assess the immunological landscape, and explore potential therapeutic strategies specifically tailored to NEPC. We discovered 1444 differentially expressed genes (DEGs) distinguishing between the two cancer types and identified 12 critical hub genes. Notably, CHST1, MPPED2, and RIPPLY3 emerged as closely associated with the immune cell infiltration pattern, establishing them as top candidates. Prognostic analysis highlighted the potential critical roles of CHST1 and MPPED2 in prostate cancer development, findings corroborated through in vitro and in vivo assays. Moreover, we validated the functions and expression levels of CHST1, MPPED2, and RIPPLY3 in NEPC using cell lines, animal models and human tissues. In the final step, we found that imatinib might be the drug specific to NEPC, which was further confirmed by in vitro cell assay. Our results revealed the clinical characteristics, molecular features, immune cell infiltration pattern in CRPC-adeno and NEPC, and identified and confirmed CHST1, MPPED2, and RIPPLY3 as the critical genes in the development in prostate cancer and NEPC. We also predicted and validated imatinib as the potential specific drugs to NEPC. - Source: PubMed
Publication date: 2025/02/24
Wang JianqingWang YuZhou HuihuiYu GuopengXu HuanGao DajunLi MinglunWang YuzhuoXu Bin - Invading species along with increased anthropogenization may lead to hybridization events between wild species and closely related domesticates. As a consequence, wild species may carry introgressed alleles from domestic species, which is generally assumed to yield adverse effects in wild populations. The opposite evolutionary consequence, adaptive introgression, where introgressed genes are positively selected in the wild species, is possible but has rarely been documented. Grey wolves (Canis lupus) are widely distributed across the Holarctic and frequently coexist with their close relative, the domestic dog (C. familiaris). Despite ample opportunity, hybridization rarely occurs in most populations. Here we studied the geographically isolated grey wolves of the Iberian Peninsula, who have coexisted with a large population of loosely controlled dogs for thousands of years in a human-modified landscape. We assessed the extent and impact of dog introgression on the current Iberian grey wolf population by analysing 150 whole genomes of Iberian and other Eurasian grey wolves as well as dogs originating from across Europe and western Siberia. We identified almost no recent introgression and a small (< 5%) overall ancient dog ancestry. Using a combination of single scan statistics and ancestry enrichment estimates, we identified positive selection on six genes (DAPP1, NSMCE4A, MPPED2, PCDH9, MBTPS1, and CDH13) for which wild Iberian wolves carry alleles introgressed from dogs. The genes with introgressed and positively selected alleles include functions in immune response and brain functions, which may explain some of the unique behavioural phenotypes in Iberian wolves such as their reduced dispersal compared to other wolf populations. - Source: PubMed
Publication date: 2025/01/10
Sarabia CarlosSalado IsabelFernández-Gil AlbertovonHoldt Bridgett MHofreiter MichaelVilà CarlesLeonard Jennifer A