Ask about this productRelated genes to: NR2E1 antibody
- Gene:
- NR2E1 NIH gene
- Name:
- nuclear receptor subfamily 2 group E member 1
- Previous symbol:
- TLX
- Synonyms:
- TLL, XTLL
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2019-01-24
Related products to: NR2E1 antibody
Related articles to: NR2E1 antibody
- Antipsychotics-induced metabolic syndrome (APs-induced MetS) is a common side-effect of antipsychotics, significantly increasing the risk of cardiovascular diseases and mortality. However, the genetic risk factors underlying APs-induced MetS remain poorly understood. Thus, we conducted a sex-stratified genome-wide association study (GWAS) in 3067 patients from Schizophrenia In Non-Occidental participants (SINO) trial, and significant results were validated in an independent cohort (all samples = 200) and proteomic data. Post-GWAS analyses were used to further explore the genetic mechanisms involved in APs-induced MetS. Multi-omics prediction incorporating both polygenic risk and proteomic markers was conducted. After quality control, 1956 patients (965 males, 991 females) were included. We identified significant genetic variants (rs73762168; P = 1.77 × 10) on chromosome 6q21, associated with three highly linked genes, NR2E1, SNX3 and AFG1L/LACE1, which were correlated with APs-induced MetS in male patients. Top SNP genotype was validated in independent cohort, showing associations with increased weight and waist circumference. Enrichment analyses across genetic and proteomic data consistently highlighted the PPAR signaling pathway involved in oxidative stress and fatty acid metabolism as a key contributor to APs-induced MetS development. Proteomic analyses confirmed baseline SNX3 protein levels associated with weight gain (P = 0.03) and increased waist circumference (P = 8.87 × 10) following six-week antipsychotic treatment. The multi-omics prediction (R = 0.18) yielded better prediction of APs-induced metabolic side effects than using either marker alone(R = 0.13 or 0.07). This study provides novel genetic insights into the development of APs-induced MetS, particularly in males. The identified genetic variants and pathways offer potential targets for early risk prediction and personalized treatment strategies. - Source: PubMed
Publication date: 2026/03/21
Zhao GuoruiSun YaoyaoLu ZheKang ZheweiYu TongZhang YuyananSun JunyuanGuo JingFeng XiaoyangYuan RuiZhu YunqingYang YangCui MingruiYue Weihua - The ventricular-subventricular zone (V-SVZ) is a specialized neurogenic niche localized on the walls of the lateral ventricles in the postnatal mammalian brain. In the V-SVZ, neural stem cells (NSCs) generate transit-amplifying neural progenitor cells, which produce neuroblasts. V-SVZ-derived neuroblasts have proliferative potential and migrate through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they differentiate into OB interneurons. However, the manner in which V-SVZ cell proliferation and OB neurogenesis are regulated during early postnatal brain development, a transition period from embryonic to adult stage, remains unclear. We focused on the role of the dynein cofactor nuclear distribution element 1 (NDE1) in early postnatal brain development. We found that Nde1 mRNA is expressed in NSCs, transit-amplifying neural progenitor cells, and neuroblasts in the V-SVZ in mice at early postnatal stage, and this expression was detected in migrating neuroblasts in the RMS and OB. Nde1 knockdown via the in vivo postnatal electroporation of Nde1 short hairpin RNA (shRNA) in a neonatal mouse brain decreased V-SVZ cell proliferation, which was rescued by overexpression of wild-type NDE1-shRNA resistant but not by overexpression of dynein-binding region-deficient NDE1-shRNA resistant. The V-SVZ cell proliferation defect was followed by impaired proliferation of V-SVZ-derived neuroblasts, thus leading to decreased generation of neuroblasts, which resulted in the reduction of newly generated OB neurons. Therefore, these results indicate that NDE1 is involved in the proliferation of NSCs and neural progenitors in the developing V-SVZ, suggesting that NDE1 plays an important role in early postnatal V-SVZ-derived neurogenesis. - Source: PubMed
Publication date: 2026/03/18
Shimizu ShokoIshino YugoMiyata Shingo - The transcription factor tailless homologue (TLX, NR2E1) maintains persistence of neural stem cells (NSCs) in a proliferating, undifferentiated state, thereby controlling NSC homeostasis and enabling neurogenesis. TLX is responsive to small-molecule ligands, offering potential access to new neuroprotective treatments, but TLX ligands are very rare. Here, we used a drug fragment screening hit as lead to develop TLX modulators and identified substructures tuning activity between agonism and inverse agonism. Structural optimization provided potent TLX activating and inhibiting fragment ligands with validated binding and favorable ligand efficiency for structural extension. - Source: PubMed
Publication date: 2026/01/28
Hank Emily CKnümann LorisLópez-García ÚrsulaKardanov ArthurMorozov VasilyHöfner GeorgMerk Daniel - Human cortical neurogenesis involves conserved and specialized developmental processes during a restricted window of prenatal development. Radial glia (RG) neural stem cells shape cortical cell diversity by giving rise to excitatory neurons, oligodendrocytes and astrocytes, as well as olfactory bulb interneurons (INs) and a recently characterized population of cortical INs. Complex genetic programs orchestrated by transcription factor (TF) circuits govern the balance between self-renewal and differentiation, and between different cell fates. Despite progress in measuring gene regulatory network activity during human cortical development, functional studies are required to evaluate the roles of TFs and effector genes in human RG lineage progression. Here we establish a human primary culture system that allows sensitive discrimination of cell fate dynamics and apply single-cell CRISPR interference (CRISPRi) screening to examine the transcriptional and cell fate consequences of 44 TFs active during cortical neurogenesis. We identified several TFs with new roles in cortical neurogenesis, including ZNF219-previously uncharacterized-that represses neural differentiation and NR2E1 and ARX that have opposing roles in regulating RG lineage plasticity and progression across developmental stages. We also detected convergent effector genes downstream of multiple TFs enriched in neurodevelopmental and neuropsychiatric disorders and observed conserved mechanisms of RG lineage plasticity across primates. We further uncovered a post-mitotic role for ARX in safeguarding IN subtype specification through repressing LMO1. Our study provides a framework for dissecting regulatory networks driving cell fate consequences during human neurogenesis. - Source: PubMed
Publication date: 2026/01/21
Ding Jingwen WKim Chang NOstrowski Megan SAbeykoon YashodaraPavlovic Bryan JWallace Jenelle LSchaefer Nathan KNowakowski Tomasz JPollen Alex A - Japanese quails () are a poultry species that is kept for meat and egg production. Genetic improvement in Japanese quails is important to increase quail farmers' income. Molecular selection can be applied in Japanese quails to increase productivity traits. - Source: PubMed
Publication date: 2025/09/30
Putra Widya Pintaka BayuBaharun AbdullahLestari Dela AyuDiansyah Athhar ManabiRahmi AnnisaSutisna Deden DwiPramartaa Ikhsan QodriRamadhan Muhammad GitarReza Muhammad Aulia