Ask about this productRelated genes to: KCNK1 antibody
- Gene:
- KCNK1 NIH gene
- Name:
- potassium two pore domain channel subfamily K member 1
- Previous symbol:
- -
- Synonyms:
- K2p1.1, DPK, TWIK-1
- Chromosome:
- 1q42.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-16
- Date modifiied:
- 2016-02-04
- Gene:
- KCNK15 NIH gene
- Name:
- potassium two pore domain channel subfamily K member 15
- Previous symbol:
- KCNK11, KCNK14
- Synonyms:
- K2p15.1, dJ781B1.1, KT3.3, KIAA0237, TASK5, TASK-5
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-15
- Date modifiied:
- 2016-02-04
Related products to: KCNK1 antibody
Related articles to: KCNK1 antibody
- KCNKs, potassium two pore domain channel family K members, can maintain the resting potential, regulate the amplitude and duration of the plateau of the action potential, and change the membrane potential and membrane excitability. Evidence from many studies indicates that KCNKs is abnormally expressed in many solid tumors and plays a regulatory role in the development and malignant progression of cancer. However, the expression pattern and prognostic value of KCNK factors in papillary thyroid carcinoma have not been reported. In this study, we used the data from databases such as ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal to perform bioinformatics analysis of KCNK factors in patients with thyroid cancer. We found that the mRNA expression of KCNK1, KCNK5, KCNK6, KCNK7, and KCNK15 were significantly higher in thyroid cancer tissues than that in normal tissues, while KCNK2, KCNK4, KCNK9, KCNK16 and KCNK17 mRNA levels were decreased compared to normal tissues. And the expression levels of KCNK1/2/4/5/6/7/15 were correlated with the tumor stage. Survival analysis using the Kaplan-Meier Plotter database revealed that KCNK2/3/4/5/12/15 were associated with overall survival (OS) in patients with thyroid cancer. Finally, the results of ROC curves, immunohistochemical staining, immune cell infiltration and kinase / miRNA / transcription factor regulation showed that KCNK2, KCNK4, KCNK5 and KCNK15 levels could be used as biomarkers for PTC diagnosis. This study implied that KCNK2, KCNK4, KCNK5 and KCNK15 are potential targets of precision therapy for patients with thyroid cancer and these genes are new biomarkers for the therapeutic target for thyroid cancer. - Source: PubMed
Publication date: 2020/06/29
Lin XuWu Jing-FangWang Dong-MeiZhang JingZhang Wen-JingXue Gang