Ask about this productRelated genes to: GABRR1 antibody
- Gene:
- GABRR1 NIH gene
- Name:
- gamma-aminobutyric acid type A receptor rho1 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6q15
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-08
- Date modifiied:
- 2016-02-04
Related products to: GABRR1 antibody
Related articles to: GABRR1 antibody
- Open-field blast injury (OFBI) is a common cause of vision loss. This study investigated OFBI-induced changes in corneal transcriptome, signaling pathways, and protein-protein interactions using RNA sequencing (RNA-seq). - Source: PubMed
Kumar RajnishSinha Nishant RGupta SuneelTripathi RatnakarSmith Charles JHofmann Alexandria CJohnson CatherineFraunfelder Frederick WMohan Rajiv R - ρ-type γ-aminobutyric acid-A (GABA) receptors are widely distributed in the retina and brain, and are potential drug targets for the treatment of visual, sleep and cognitive disorders. Endogenous neuroactive steroids including β-estradiol and pregnenolone sulfate negatively modulate the function of ρ1 GABA receptors, but their inhibitory mechanisms are not clear. By combining five cryo-EM structures with electrophysiology and molecular dynamics simulations, we characterize binding sites and negative modulation mechanisms of β-estradiol and pregnenolone sulfate at the human ρ1 GABA receptor. β-estradiol binds in a pocket at the interface between extracellular and transmembrane domains, apparently specific to the ρ subfamily, and disturbs allosteric conformational transitions linking GABA binding to pore opening. In contrast, pregnenolone sulfate binds inside the pore to block ion permeation, with a preference for activated structures. These results illuminate contrasting mechanisms of ρ1 inhibition by two different neuroactive steroids, with potential implications for subtype-specific gating and pharmacological design. - Source: PubMed
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Zhang PingLu YongkeLi YanliWang KeshengAn HuimeiTan Yunlong - The pandemic of overweight and obesity (quantified by body mass index (BMI) ≥ 25) has rapidly raised the patient number of non-alcoholic fatty hepatocellular carcinoma (HCC), and several clinical trials have shown that BMI is associated with the prognosis of HCC. However, whether overweight/obesity is an independent prognostic factor is arguable, and the role of overweight/obesity-related metabolisms in the progression of HCC is scarcely known. - Source: PubMed
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