Ask about this productRelated genes to: GABRR1 antibody
- Gene:
- GABRR1 NIH gene
- Name:
- gamma-aminobutyric acid type A receptor rho1 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6q15
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-08
- Date modifiied:
- 2016-02-04
Related products to: GABRR1 antibody
Related articles to: GABRR1 antibody
- Electronic feeders record feeding behavior, enabling identification of feeder replacement events and application of social network analysis (SNA) to characterize individual roles within group dynamics. We estimated genetic parameters for SNA-related traits and performed a single-step weighted genome-wide association (ssWGWAS) in Nellore cattle. Data from 1367 young animals from 32 feed efficiency trials were used to quantify feeder replacement networks. Betweenness and closeness centrality, clustering coefficient, and degree centrality were analyzed using single-step GBLUP models integrating pedigree (n = 5069) and genomic (n = 3860) information. Heritability estimates were low for betweenness centrality (0.04 ± 0.03), closeness centrality (0.05 ± 0.03) clustering coefficient (0.14 ± 0.04) and degree centrality (0.18 ± 0.05). The strongest genetic correlation was observed between closeness and degree centrality (0.81 ± 0.20), whereas the remaining correlations were generally low to moderate, including weak negative associations of clustering coefficient with closeness (- 0.24 ± 0.49) and degree centrality (- 0.09 ± 0.21). The ssWGWAS identified regions harboring genes linked to neural plasticity, motivation, social regulation, and stress responsiveness, including GABRR1, RBFOX1, MET, COMT, CHRNA6, and FOXP2. SNA-related traits showed limited additive genetic variation and were associated with genomic regions involved in neural and behavioral regulation. - Source: PubMed
Publication date: 2026/07/09
Valente Julia P SMota Lucio F MRodrigues Gustavo R DMartins RafaelaSoares Tainara L SSilva Joel ACanesin Roberta CBorges Gustavo H CDeniz MatheusCosta Joao H CMercadante Maria E Z - Open-field blast injury (OFBI) is a common cause of vision loss. This study investigated OFBI-induced changes in corneal transcriptome, signaling pathways, and protein-protein interactions using RNA sequencing (RNA-seq). - Source: PubMed
Kumar RajnishSinha Nishant RGupta SuneelTripathi RatnakarSmith Charles JHofmann Alexandria CJohnson CatherineFraunfelder Frederick WMohan Rajiv R - ρ-type γ-aminobutyric acid-A (GABA) receptors are widely distributed in the retina and brain, and are potential drug targets for the treatment of visual, sleep and cognitive disorders. Endogenous neuroactive steroids including β-estradiol and pregnenolone sulfate negatively modulate the function of ρ1 GABA receptors, but their inhibitory mechanisms are not clear. By combining five cryo-EM structures with electrophysiology and molecular dynamics simulations, we characterize binding sites and negative modulation mechanisms of β-estradiol and pregnenolone sulfate at the human ρ1 GABA receptor. β-estradiol binds in a pocket at the interface between extracellular and transmembrane domains, apparently specific to the ρ subfamily, and disturbs allosteric conformational transitions linking GABA binding to pore opening. In contrast, pregnenolone sulfate binds inside the pore to block ion permeation, with a preference for activated structures. These results illuminate contrasting mechanisms of ρ1 inhibition by two different neuroactive steroids, with potential implications for subtype-specific gating and pharmacological design. - Source: PubMed
Publication date: 2024/09/06
Fan ChenCowgill JohnHoward Rebecca JLindahl Erik - Gangba sheep as a famous breed of Tibetan sheep, its wool color is mainly white and black. Gangba wool is economically important as a high-quality raw material for Tibetan blankets and Tibetan serge. However, relatively few studies have been conducted on the wool color of Tibetan sheep. - Source: PubMed
Publication date: 2024/06/17
Zhang WentaoLuosang CuichengYuan ChaoGuo TingtingWei CaihongLiu JianbinLu Zengkui - Tardive dyskinesia (TD) develops in 20-30% of schizophrenia patients and up to 50% in patients > 50 years old. DNA methylation may play an important role in the development of TD. - Source: PubMed
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