Ask about this productRelated genes to: ACCN4 antibody
- Gene:
- ASIC4 NIH gene
- Name:
- acid sensing ion channel subunit family member 4
- Previous symbol:
- ACCN4
- Synonyms:
- BNAC4
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-05
- Date modifiied:
- 2016-10-05
Related products to: ACCN4 antibody
Related articles to: ACCN4 antibody
- Immune evasion is a major cause of the poor efficacy of therapies for pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which MHC-I downregulation leads to low infiltration of cytotoxic T lymphocytes in PDAC remains incompletely elucidated. This study aims to identify the molecules responsible for the low expression of MHC-I and potential novel therapeutic targets, thereby providing a theoretical foundation for reversing immune evasion in pancreatic cancer. - Source: PubMed
Publication date: 2026/02/24
An QiAn ZhongwuBo WeiboYan ChaochunSun NanMa JianxinLi JianyeWang Wenjuan - Menopausal syndrome (MPS) is a symptom of physical and psychosomatic abnormalities that women may face around the time of menopause. Hot flashes are the main symptom. Paeonia lactiflora extract (PLE) is the active ingredient extracted from . It can be used to treat MPS, such as hot flashes. However, its pharmacologic mechanism is unclear. - Source: PubMed
Publication date: 2025/07/22
Cui WeilinSong TingtingGao DongmeiWang XiaoyuSun YaFu LiyuHan YichaoWang Jieqiong - Lower-grade glioma (LGG) is a molecularly heterogeneous tumor in which acidic microenvironments and immune interactions critically influence prognosis. Acid-sensing ion channels (ASICs), particularly ASIC1, remain understudied in glioma biology despite their pH-sensing roles. This study investigates ASIC1/ASIC4 in LGG prognosis, immune regulation, and molecular subtyping. - Source: PubMed
Publication date: 2025/07/25
Mao KeleiGuo AngyangLi YizeYang WendiXiong YiduoWang WeiYan Xiaodong - Ion channels play a crucial role in various physiological processes, yet their functions in the reproductive system remain underexplored. This study investigates the expression and the localization of ASIC2, ASIC4, and PIEZO2 ion channels in the reproductive tracts of prepubertal bitches. Western blotting on samples from eight prepubertal bitches confirmed the presence of these ion channels in ovarian, uterine, and uterine tubes tissues, and validated antibody specificity. Immunohistochemistry revealed that all primordial follicles expressed these ion channels, while only some developing follicles showed immunolabeling. These findings suggest ion channels' potential involvement in oocyte differentiation and maturation. The localization of these channels in uterine tubes, uterine lining, and glandular epithelium suggests a role in tissue maintenance, oocyte transport, and embryo implantation. Additionally, their expression in the tunica media of reproductive vasculature points to a potential role in vascular regulation. Future studies are needed to elucidate the specific mechanisms underlying the role of these channels in reproductive physiology. - Source: PubMed
Publication date: 2025/05/05
Mhalhel KamelCavallaro MauroPansera LidiaFranco Gianluca AntonioMontalbano GiuseppeLaurà RosariaAbbate FrancescoGermanà AntoninoLevanti MariaAragona Marialuisa - Anxiety is an innate response in the face of danger. When anxiety is overwhelming or persistent, it could be considered an anxiety disorder. Recent studies have shown that acid-sensing ion channels (ASICs) represent a novel class of promising targets for developing effective therapies for anxiety. Especially, ASIC1a and ASIC4 of the ASIC family are widely expressed in the central nervous system and their gene knockouts result in reducing or enhancing anxiety-like responses in mice respectively. However, how ASIC1a and ASIC4 modulate anxiety-associated responses remains unknown. - Source: PubMed
Publication date: 2025/04/22
Chien Ya-ChihLin Shing-HongLien Cheng-ChangWood John NChen Chih-Cheng