Ask about this productRelated genes to: FXR1 antibody
- Gene:
- FXR1 NIH gene
- Name:
- FMR1 autosomal homolog 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q26.33
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-16
- Date modifiied:
- 2016-10-05
Related products to: FXR1 antibody
Related articles to: FXR1 antibody
- Liver metastasis remains a major cause of mortality in patients with colorectal cancer (CRC). Here, we identify OTUD6B, a deubiquitinating enzyme of the OTU family, as a key driver of CRC liver metastasis. OTUD6B is upregulated in metastatic CRC tissues and is correlated with poor prognosis. Functionally, OTUD6B promotes CRC cell proliferation, migration, and invasion in vitro and enhances tumor growth and liver metastasis in vivo. Mechanistically, OTUD6B binds the KH domain of fragile X-related protein 1 (FXR1) via its N-terminal region and stabilizes FXR1 by removing K48-linked polyubiquitin chains in a catalytic activity-dependent manner. In turn, FXR1 binds and stabilizes MEK2 mRNA, leading to increased MEK2 expression and activation of ERK signaling. Notably, FXR1 also upregulates OTUD6B expression, establishing a feed-forward loop that amplifies the oncogenic OTUD6B-FXR1-MEK2/ERK axis. OTUD6B, FXR1, and MEK2 levels are positively correlated in clinical CRC liver metastasis samples. Crucially, the MEK2 inhibitor U0126 acts synergistically with OTUD6B silencing to suppress liver metastasis. Collectively, these findings delineate a previously unrecognized oncogenic cascade in which OTUD6B stabilizes FXR1 to activate MEK2/ERK signaling, thereby driving CRC liver metastasis. Dual targeting of OTUD6B and MEK2 may represent a promising therapeutic strategy for advanced CRC. - Source: PubMed
Publication date: 2026/04/29
Lu YingLiu JiLi Ya-NanXiang LinSong Guo-BinPeng TianWang ZhenYang XueYing Hou-QunCheng Xue-Xin - [This corrects the article DOI: 10.3892/ol.2022.13608.]. - Source: PubMed
Publication date: 2026/04/09
Zhao KunGao JieShi JihuaShi ChengchengPang ChunLi JieGuo WenzhiZhang Shuijun - Fragile X-related protein 1 (FXR1), an RNA-binding protein (RBP) implicated in various cancers, has emerged as a potential contributor to the progression of head and neck squamous cell carcinoma (HNSCC). - Source: PubMed
Publication date: 2026/04/22
Manicka Vasagam JeevithaKannan BalachanderJayaseelan Vijayashree PriyadharsiniArumugam Paramasivam - Extracellular tumor-derived DNA (tDNA) has emerged as an important biomarker for cancer diagnosis and monitoring. A better understanding of the mechanisms controlling the abundance of tDNA could help improve biomarker and treatment strategies. Here, we identified oncogenic KRAS as a critical regulator of tDNA levels. Mutant KRAS promoted tDNA clearance by inducing the tetraspanin CD9, which recruited FXR1 to remodel the actin cortex, lower plasma-membrane tension, and promote endocytic uptake of extracellular tDNA. The reduction in tDNA dampened ZBP1-dependent DNA sensing in tumor-associated macrophages (TAMs), shifting them toward an immunosuppressive state. Blockade of CD9 restored extracellular tDNA and DNA sensing, reprogrammed TAMs, and synergized with PD-1 blockade in KRAS-mutant cancer models. These findings delineate a KRAS-CD9-FXR1 pathway that couples membrane mechanics to extracellular DNA clearance and immune evasion, providing a strong rationale for targeting CD9 to augment the efficacy of immune checkpoint blockade therapy. - Source: PubMed
Publication date: 2026/04/19
Cao DiZhou WeiyiLi ZhixiongLu ShixunHou ZhenlinYu LongGuan YuanjunWang GuoqiangLiu YifanHuang ZhijieWang HaoDai JingyiLi CongWang JingChen Gong - Proteasome experiences sophisticated dynamics in types, quantities, and activities during spermiogenesis. However, the physiological importance of proteasomal degradation in mammalian spermiogenesis remains largely unknown. Here, we report that the PSMA8-containing spermato-20S proteasome (s20S) is required for spermiogenesis and male fertility in mice. In a mutant mouse model that the C-terminal 30-amino-acid (C30) of PSMA8 is substituted by PSMA7-C30, the resulting PSMA8 protein is unstable, which further disrupts the assembly of s20S and subcellular localization of 19S regulatory particle in testes. Psma8 males could produce round spermatids, but sperm formation is delayed and abnormal, exhibiting a phenotype of oligoasthenoteratozoospermia. s20S is required for the ubiquitination-dependent proteasomal degradation of a group of proteins in elongating spermatids. These s20S-mediated degradation events are essential for liquid-liquid phase separation of FXR1 and thereby translational-activation of its substrates. Taken together, these findings provide an in vivo evidence of protein homeostasis control in spermiogenesis in mammals. - Source: PubMed
Publication date: 2026/04/13
Cao HuiwenZhang QiantingXu WeiFang AnxuanXu HaomangQiu ChengHe LugengYu Chao