Ask about this productRelated genes to: TIA1 antibody
- Gene:
- TIA1 NIH gene
- Name:
- TIA1 cytotoxic granule associated RNA binding protein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-01
- Date modifiied:
- 2016-10-05
Related products to: TIA1 antibody
Related articles to: TIA1 antibody
- Cellular senescence is a complex stress response characterized not only by stable growth arrest but also by chromatin remodeling, altered proteostasis, metabolic adaptation, innate immune activation, and the senescence-associated secretory phenotype. Stress granules (SGs) are dynamic membraneless ribonucleoprotein condensates that form during translational stress and regulate mRNA triage, signaling and recovery. While both senescence and SGs represent important features of cellular stress response, the mechanisms underlying their intersection remain poorly defined. This review examines how the biology of SGs and RNA-binding proteins (RBPs) regulate senescence, with particular emphasis on stress granule-induced inflammation associated with SASP, activation of cGAS-STING, induction of NF- κB signaling, and interferon response. We discuss the differential ability of senescence inducers to generate canonical SGs and why SG formation does not necessarily result in global translational shutdown. In addition, we examine the potential roles of SG-associated RBPs, including G3BP1/2, TIA1/TIAR, CAPRIN1, USP10, HuR, ZFP36 family, FXR1, and TDP-43 together with methodological standards for identifying SGs in senescence. We present a stage-resolved modular framework describing the context-dependent functions of SG-associated RBPs throughout senescence progression and discuss therapeutic opportunities. Overall, this review suggests that stress granules and associated RNA-binding proteins should be considered context-dependent components in inflammation-driven senescence, rather than universal inducers of senescence onset. - Source: PubMed
Publication date: 2026/09/25
Bahraminasab MaryamAl-Rashdi Janan SalehDarweesh MahmoudMohammadi SaeedAl-Amri Issa SulaimanAl-Harrasi AhmedAl-Roshdi Maha Rashid - To report a rare case of recurrent intestinal perforation caused by primary intestinal extranodal NK/T-cell lymphoma (ENKTL), analyze the diagnostic challenges of this rare and aggressive malignancy, and raise clinical awareness for its early identification and optimal management in patients with unexplained gastrointestinal perforation. - Source: PubMed
Su JiansenYang YixiaoHuang XinyiWen Liang - Primary cutaneous anaplastic large cell lymphoma (pcALCL) is an indolent CD30+ T-cell lymphoma, typically of T-cell receptor (TCR)-αβ origin with an excellent prognosis. Rare cases may exhibit a TCR-ϒδ phenotype or rearrangement of the DUSP22 and IRF4 genes on chromosome 6p25.3, but the concurrence of both features is exceedingly rare. We present herein a case of a 78-year-old man with a history of pcALCL who, 5 years after achieving complete remission with radiation therapy, experienced a recurrent neck nodule. Histopathological examination revealed a dense dermal infiltrate of medium to large atypical lymphoid cells. The lesion was strongly positive for CD30, TCR-δ, and LEF1 but negative for CD4, CD8, CD7, TCR-β, and ALK, and TIA-1. p-STAT3 was predominantly negative with labeling of few scattered cells. Fluorescence in situ hybridization studies confirmed a DUSP22-IRF4 abnormality. In view of immunohistochemical findings (LEF1+, TIA-1-, predominantly p-STAT3-), an unbalanced DUSP22-IRF4 rearrangement was favored. A diagnosis of pcALCL with TCR-ϒδ phenotype and DUSP22-IRF4 unbalanced rearrangement was rendered. This case adds to the small but growing number of reported cases of pcALCL with TCR-ϒδ phenotype and DUSP22-IRF4 alteration. - Source: PubMed
Publication date: 2026/09/09
Ibrahim ElsayedCho Woo ChealToruner Gokce AltayHuen AurisTorres-Cabala Carlos ACurry Jonathan L - Stress granules (SGs) are highly dynamic and reversible cytoplasmic biomolecular condensates formed via liquid-liquid phase separation (LLPS) under various stresses. As inherently heterogeneous assemblies, SGs possess distinct stable cores (initial nucleation seeds), substructures, or microphases. However, the mechanisms governing the formation and heterogeneity of SG nucleation seeds, and their dynamic integration, remain largely unclear. Here, we demonstrate that LENG8 is recruited to SGs under multiple stress conditions and is indispensable for SG assembly. Upon stress exposure, nuclear LENG8 granules disassemble, enabling LENG8 to translocate into the cytoplasm and undergo LLPS to form independent initial nucleation foci distinct from canonical G3BP1/TIA1-dependent seeds. Subsequently, these LENG8-initiated foci merge into growing SGs through a direct interaction between the prion-like domain of LENG8 and TIA1, facilitating SG expansion and maturation. Depletion of LENG8 or disruption of the LENG8-TIA1 interaction markedly impairs SG formation. Using conditional Leng8 knockout mice, we further establish that LENG8 deficiency attenuates stress-induced SG assembly and increases cellular apoptosis in germ cells. Collectively, our study identifies LENG8 as a previously unrecognized SG nucleator, revealing the hierarchical assembly and integration mechanism of distinct nucleation modules during early SG biogenesis. - Source: PubMed
Publication date: 2026/09/08
Zhang MingxingWang XinTeng YilanWu ZhichengFan JingZhu HongwenDai Peng - Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases of the central nervous system. The role of microRNA-34b (miR-34b) in NMOSD pathogenesis remains unclear. This study investigates the expression and functional mechanism of miR-34b in NMOSD, specifically its regulation of the TIA-1-stress granule pathway. - Source: PubMed
Dai YanDai AnlangLiu Yuhuan