Ask about this productRelated genes to: SRPR antibody
- Gene:
- SRPRA NIH gene
- Name:
- SRP receptor subunit alpha
- Previous symbol:
- SRPR
- Synonyms:
- SRP-alpha, Sralpha, SR-alpha
- Chromosome:
- 11q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2018-04-23
Related products to: SRPR antibody
Related articles to: SRPR antibody
- Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease among preterm infants, largely attributed to hyperoxia-induced injury to alveolar epithelial cells. Excessive endoplasmic reticulum (ER) stress plays a vital role in BPD progression. SRPRA, a subunit of the ER-localized SRP receptor, is upregulated in BPD, while its function and link with ER stress remain largely unclear. This study aimed to explore the role of SRPRA in hyperoxia-induced BPD and its underlying mechanism. - Source: PubMed
Publication date: 2026/07/19
Tan YanlinXiong ShisiNi WenchangWang LiyanBian Junmei - Sepsis is a global health burden characterized by high heterogeneity and uncontrolled immune response, with a notable lack of reliable methods for early prognosis and risk stratification. Epigenetic modifications, particularly lactylation, have recently emerged as key regulators in the early pathophysiology of sepsis. However, their potential for immune-related mortality risk stratification remains largely unexplored. This study aimed to investigate dynamic changes in lactylation during sepsis progression and to develop a rapid, lactylation-based prognostic signature. - Source: PubMed
Publication date: 2025/06/19
Li ChangHe MeiShi PeiChiYao LuFang XiangZhiLi XueFengLi QiLanYang XiaoBoXu JiQianShang You - Signal recognition particle (SRP) pathway function in protein translocation across the endoplasmic reticulum (ER) is well established; its role in RNA localization to the ER remains, however, unclear. In current models, mRNAs undergo translation- and SRP-dependent trafficking to the ER, with ER localization mediated via interactions between SRP-bound translating ribosomes and the ER-resident SRP receptor (SR), a heterodimeric complex comprising SRA, the SRP-binding subunit, and SRB, an integral membrane ER protein. To study SRP pathway function in RNA localization, SR knockout (KO) mammalian cell lines were generated and the consequences of SR KO on steady-state and dynamic mRNA localization examined. CRISPR/Cas9-mediated KO resulted in profound destabilization of SRA. Pairing siRNA silencing of in KO cells yielded viable SR KO cells. Steady-state mRNA compositions and ER-localization patterns in parental and SR KO cells were determined by cell fractionation and deep sequencing. Notably, steady-state cytosol and ER mRNA compositions and partitioning patterns were largely unaltered by loss of SR expression. To examine SRP pathway function in RNA localization dynamics, the subcellular trafficking itineraries of newly exported mRNAs were determined by 4-thiouridine (4SU) pulse-labeling/4SU-seq/cell fractionation. Newly exported mRNAs were distinguished by high ER enrichment, with ER localization being SR-independent. Intriguingly, under conditions of translation initiation inhibition, the ER was the default localization site for all newly exported mRNAs. These data demonstrate that mRNA localization to the ER can be uncoupled from the SRP pathway function and reopen questions regarding the mechanism of RNA localization to the ER. - Source: PubMed
Publication date: 2023/08/29
Child Jessica RHofler Alex CChen QiangYang Brenda HKristofich JohnCarloZheng TianliHannigan Molly MElles Andrew LReid David WNicchitta Christopher V - Since the environmental, behavioral, and socioeconomic factors in the etiology of keratoconus (KTCN) remain poorly understood, we characterized them as features influencing KTCN phenotype, and especially affecting the corneal epithelium (CE). In this case-control study, 118 KTCN patients and 73 controls were clinically examined and the Questionnaire covering the aforementioned aspects was completed and then statistically elaborated. Selected KTCN-specific findings were correlated with the outcomes of the RNA-seq assessment of the CE samples. Male sex, eye rubbing, time of using a computer after work, and dust in the working environment, were the substantial KTCN risk factors identified in multivariate analysis, with ORs of 8.66, 7.36, 2.35, and 5.25, respectively. Analyses for genes whose expression in the CE was correlated with the eye rubbing manner showed the enrichment in apoptosis (TP53, BCL2L1), chaperon-related (TLN1, CTDSP2, SRPRA), unfolded protein response (NFYA, TLN1, CTDSP2, SRPRA), cell adhesion (TGFBI, PTPN1, PDPK1), and cellular stress (TFDP1, SRPRA, CAPZB) pathways. Genes whose expression was extrapolated to the allergy status didn't contribute to IgE-related or other inflammatory pathways. Presented findings support the hypothesis of chronic mechanical corneal trauma in KTCN. Eye-rubbing causes CE damage and triggers cellular stress which through its influence on cell apoptosis, migration, and adhesion affects the KTCN phenotype. - Source: PubMed
Publication date: 2023/04/13
Jaskiewicz KatarzynaMaleszka-Kurpiel MagdalenaMichalski AndrzejPloski RafalRydzanicz MalgorzataGajecka Marzena - Bronchopulmonary dysplasia (BPD) is the most common neonatal chronic lung disease. However, its exact molecular pathogenesis is not understood. We aimed to identify relevant gene modules that may play crucial roles in the occurrence and development of BPD by weighted gene co-expression network analysis (WGCNA). - Source: PubMed
Publication date: 2022/11/07
Yu XuefeiLiu ZiyunPan YuqingCui XueweiZhao XinyiLi DanniXue XindongFu Jianhua