Ask about this productRelated genes to: IREB2 antibody
- Gene:
- IREB2 NIH gene
- Name:
- iron responsive element binding protein 2
- Previous symbol:
- -
- Synonyms:
- IRP2
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-20
- Date modifiied:
- 2015-11-12
Related products to: IREB2 antibody
Related articles to: IREB2 antibody
- Early brain injury (EBI) occurring within the first 72 h is a critical determinant of outcome after subarachnoid hemorrhage (SAH), yet effective treatments remain limited. Ferroptosis and mitochondrial dysfunction are central mechanisms in EBI. This study investigated whether deferoxamine (DFO), a clinically approved iron chelator, alleviates EBI after SAH via ferroptosis inhibition and mitochondrial restoration. - Source: PubMed
Publication date: 2026/04/26
Liu GuodongShan WenZhang ZhiyuanWei WutingWei YuBai WanshanDai JingLin Yixing - Hexavalent Chromium [Cr(VI)], a Group 1 carcinogen designated by the International Agency for Research on Cancer (IARC), is a pervasive environmental pollutant. The kidneys are particularly vulnerable to Cr(VI)-induced damage, and emerging evidence suggests that ferroptosis plays a pivotal role in Cr(VI) toxicity. - Source: PubMed
Publication date: 2026/04/14
Qi ChangxiLi MuziYu YueLi JiayiXia YiboLi LinjueCheng GuodongZheng PimiaoLiu YongxiaZhang PuLiu JianzhuZhao Xiaona - Pediatric asthma (PA) is a chronic airway disease with a complex etiology, and iron metabolism disorder is believed to be involved in its pathogenesis. In this study, we integrated three peripheral blood transcriptome datasets from the GEO database (GSE27011, GSE40888, GSE40732), which included 283 samples (155 in the PA group and 128 in the control group), and conducted a comprehensive analysis after normalization and batch effect correction. Differential expression analysis identified 15 iron metabolism-related differentially expressed genes (IMRDEGs), including C19orf12, IREB2, XK, GDF15. Functional enrichment analysis showed that these genes mainly participate in cellular energy metabolism, oxidative stress response, and regulation of iron homeostasis. A discrimination model based on machine learning algorithms isolated four key genes, with an area under the receiver operating characteristic curve of 0.69, indicating moderate diagnostic discrimination. qRT-PCR analysis of independent blood samples showed that C19orf12 expression was upregulated in patients with PA, while IREB2 expression was downregulated, consistent with bioinformatics analysis results. Immune infiltration analysis revealed significant differences in the proportions of memory CD4 + T cells and mast cells between high-risk and low-risk groups, suggesting that iron metabolism imbalance may contribute to asthma development via immune regulatory mechanisms. This study provides combined support from transcriptomic and experimental data for the potential role of IMRGs in PA, serving as a basis for further mechanistic research and clinical validation. - Source: PubMed
Publication date: 2026/04/15
Liu LiangSun YingyingWang YuXie XiaofeiWei Lina - Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVDs), including hypertension (HTN), coronary heart disease (CHD), and heart failure (HF), are major global health burdens. The shared genetic mechanisms underlying the high comorbidity between COPD and CVDs remain unclear. - Source: PubMed
Publication date: 2026/01/08
Chen ShiyuLi XiaojianXie Rongfang - Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation, with its pathogenesis remaining elusive. Genetic factors are recognized as crucial factors in the pathogenesis of COPD. - Source: PubMed
Publication date: 2026/03/07
Luan HaoWang TianhuaSu XinjieZhao JundeYuan ZiDing ShengkaiYang Yikun